The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

UL11  -  envelope-associated

Human herpesvirus 1

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of UL11

  • Packaging Determinants in the UL11 Tegument Protein of Herpes Simplex Virus Type 1 [1].
  • Purified virions were found to contain approximately 700 copies of the UL11 protein per particle, making it an abundant component of the tegument [1].
  • Wild-type HSV-1 strain 17syn+ expresses three electrophoretically distinguishable UL11 polypeptide species [2].
  • An insertion mutant containing the lacZ gene from Escherichia coli within the UL11 open reading frame is viable in tissue culture, although it gives smaller plaques and is impaired for growth compared to the wild-type parent or revertant viruses; it does not have a temperature-sensitive or host-range phenotype [2].
 

High impact information on UL11

  • Although the mechanism by which UL11 is packaged is unknown, previous studies have identified several sequence motifs in the protein that are important for membrane binding, intracellular trafficking, and interaction with UL16, another tegument protein [1].
  • The UL11 gene of herpes simplex virus type 1 encodes a 96-amino-acid tegument protein that is myristylated, palmitylated, and phosphorylated and is found on the cytoplasmic faces of nuclear, Golgi apparatus-derived, and plasma membranes of infected cells [1].
  • Thus, something other than mere localization of UL11 to Golgi apparatus-derived membranes is needed for packaging [1].
  • In this paper we have characterized the UL11 product further and investigated its role in the virus life cycle [2].

References

  1. Packaging Determinants in the UL11 Tegument Protein of Herpes Simplex Virus Type 1. Loomis, J.S., Courtney, R.J., Wills, J.W. J. Virol. (2006) [Pubmed]
  2. The myristylated virion proteins of herpes simplex virus type 1: investigation of their role in the virus life cycle. MacLean, C.A., Dolan, A., Jamieson, F.E., McGeoch, D.J. J. Gen. Virol. (1992) [Pubmed]
 
WikiGenes - Universities