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DIEXF  -  digestive organ expansion factor homolog...

Homo sapiens

Synonyms: C1orf107, DEF, DJ434O14.5, Digestive organ expansion factor homolog, MGC29875, ...
 
 
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Disease relevance of C1orf107

  • In order to study the structural details of ligand protein interactions of the human retinoid X receptor alpha (hRXR alpha), the DEF and EF domains of the receptor were expressed as glutathione S-transferase (GST) fusion proteins in Escherichia coli [1].
  • OSAHS patients with PN had a higher prevalence of peripheral edema, higher BMI, a greater %TST < 90% SPO2, lower nadir SPO2 and greater DEF [2].
  • PATIENTS AND METHODS: Twenty patients were selected; 10 women with cervical cancer treated with definitive radiotherapy (group 'DEF') and 10 endometrial cancer patients treated postoperatively (group 'POST') [3].
  • Addition of 100 ppm DEF to the diet increased both the retention time and the toxicity of diflubenzuron in both T. castaneum and S. littoralis, which was due probably to the inhibition of diflubenzuron hydrolase activity [4].
  • The authors present an unreported variant of SNS having dorsal enteric diverticulum adjacent to the DEF [5].
 

High impact information on C1orf107

  • The results of these analyses define three functional domains of the DEF A protein and identify in the deficiens promoter a possible cis-acting binding site for a transcription factor which specifically upregulates expression of deficiens in petals and stamens [6].
  • In vitro DNA binding studies show that DEF A binds to specific DNA motifs as a heterodimer, together with the protein product of the floral homeotic globosa gene, thus demonstrating that the protein encoded by deficiens is a DNA binding protein [6].
  • We discuss the structure and the possible function of the DEF A protein in the control of floral organogenesis [7].
  • At its N-terminus the DEF A protein reveals homology to a conserved domain of the regulatory proteins SRF (activating c-fos) in mammals and GRM/PRTF (regulating mating type) in yeast [7].
  • Nevertheless, this activity is sufficient to allow the expansion of petal lobes, highlighting the role of DEF in the stimulation of cell proliferation and/or cell shape and elongation when expressed in the L1 layer [8].
 

Chemical compound and disease context of C1orf107

 

Biological context of C1orf107

  • MAPK phosphorylation of various substrates is mediated by the presence of docking sites, including the D domain and the DEF motif [14].
  • To investigate if OsMADS16 functions as an AP3/DEF orthologue to regulate the development of lodicules and stamens in rice, we isolated its genomic sequences and characterized its functions in planta by RNA interference [15].
  • On RARalpha and RXRalpha, the sequences correspond to the DEF and DE domains, respectively, but the interaction with CRABPII does not require the AF-2AD 'core'. On CRABPII, two interacting domains are identified (NRID1 and NRID2), one of which contains the only enhancement transactivation domain of CRABPII [16].
  • In vitro DNA-binding studies complemented with molecular genetic analysis of the respective mutants show that the DEF and GLO proteins may act together in the form of a heterodimer in the regulation of their target genes as well as in autoregulation [17].
  • SaMADS D gene of Sinapis alba was isolated by screening a cDNA library from young inflorescences with a mixture of MADS-box genes of Antirrhinum majus (DEF, GLO, SQUA) as probe [18].
 

Anatomical context of C1orf107

  • The scu-PA activator activity (scuPA-AA) in the DEF of plasmas deficient in factor XII or prekallikrein was about half of that in the DEF of normal plasma [19].
  • Main differences between POST and DEF patients receiving IM-WPRT were absolute volumes of LB irradiated to doses between 35 and 50Gy, suggesting an impact of intact uterus on LB volume in the pelvis [3].
  • A new type of antigen presenting molecule (dimeric MHC class-II/peptide, DEF) endowed with antigen-specific immunomodulatory effects such as induction of Th2 polarization and T-cell anergy is also described as a potential antidiabetogenic agent [20].
 

Associations of C1orf107 with chemical compounds

  • Both methods of analysis indicate that while the cleaved DEF peptide bound 9-cis-retinoic acid tightly, the cleaved EF peptide exhibited variable binding activity between preparations [1].
  • Identification of a DEF-type docking domain for extracellular signal-regulated kinases 1/2 that directs phosphorylation and turnover of the BH3-only protein BimEL [21].
  • Certain OPs are exploited for their anticholinesterase effects, including defoliants such as 'DEF', herbicides such as glyphosate, fire retardants and industrial intermediates [22].
  • Together, these results support a model in which the conformational flexibility of the G residue facilitates conversion to the skew boat conformer and thereby allows charged groups of the GH disaccharide to bind and stabilize the activated antithrombin conformation that is induced by the DEF trisaccharide [23].
  • Using this approach, a small, nonsugar, aromatic molecule, (minus sign)-epicatechin sulfate (ECS), was designed to mimic the nonreducing end trisaccharide unit DEF of the sequence specific heparin pentasaccharide DEFGH [24].
 

Analytical, diagnostic and therapeutic context of C1orf107

  • Using both mammalian two-hybrid and immunoprecipitation/Western methods, we demonstrate a direct interaction between the region DEF of RARgamma and the MH2 domain of Smad3, inhibited by RAR agonists and enhanced by their antagonists [25].
  • Separation of scuPA-AA in the DEF by gel chromatography showed to major peaks, one eluting with an apparent Mr of 500,000 and the other around Mr 100,000 [19].
  • A control group (DEF, n=12) was managed by deferred therapy [26].
  • Soluble, dimeric MHC class II-peptide (DEF) chimeras have potential for both early diagnosis and immunospecific therapy [27].
  • A prospective randomized study to compare discectomy without (DE) and with fusion (DEF) included 63 patients operated on with DE returned to work during the first 9 weeks postoperatively than patients operated on with DEF (p less than 0.005 to 0.05) [28].

References

  1. Characterization of the ligand binding domain of human retinoid X receptor alpha expressed in Escherichia coli. Cheng, L., Norris, A.W., Tate, B.F., Rosenberger, M., Grippo, J.F., Li, E. J. Biol. Chem. (1994) [Pubmed]
  2. Prevalence and predictors of nocturia in obstructive sleep apnea-hypopnea syndrome--a retrospective study. Hajduk, I.A., Strollo, P.J., Jasani, R.R., Atwood, C.W., Houck, P.R., Sanders, M.H. Sleep. (2003) [Pubmed]
  3. Factors influencing bowel sparing in intensity modulated whole pelvic radiotherapy for gynaecological malignancies. Georg, P., Georg, D., Hillbrand, M., Kirisits, C., Pötter, R. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (2006) [Pubmed]
  4. Insect detoxifying enzymes: their importance in pesticide synergism and resistance. Ishaaya, I. Arch. Insect Biochem. Physiol. (1993) [Pubmed]
  5. A case of split notochord syndrome: presence of dorsal enteric diverticulum adjacent to the dorsal enteric fistula. Akgür, F.M., Ozdemir, T., Olguner, M., Erbayraktar, S., Ozer, E., Aktuğ, T. J. Pediatr. Surg. (1998) [Pubmed]
  6. Characterization of the Antirrhinum floral homeotic MADS-box gene deficiens: evidence for DNA binding and autoregulation of its persistent expression throughout flower development. Schwarz-Sommer, Z., Hue, I., Huijser, P., Flor, P.J., Hansen, R., Tetens, F., Lönnig, W.E., Saedler, H., Sommer, H. EMBO J. (1992) [Pubmed]
  7. Deficiens, a homeotic gene involved in the control of flower morphogenesis in Antirrhinum majus: the protein shows homology to transcription factors. Sommer, H., Beltrán, J.P., Huijser, P., Pape, H., Lönnig, W.E., Saedler, H., Schwarz-Sommer, Z. EMBO J. (1990) [Pubmed]
  8. Non-cell-autonomous function of the Antirrhinum floral homeotic proteins DEFICIENS and GLOBOSA is exerted by their polar cell-to-cell trafficking. Perbal, M.C., Haughn, G., Saedler, H., Schwarz-Sommer, Z. Development (1996) [Pubmed]
  9. Toxicity of the herbicides 2,4-D, DEF, propanil and trifluralin to the Dungeness crab, Cancer magister. Caldwell, R.S., Buchanan, D.V., Armstrong, D.A., Mallon, M.H., Millemann, R.E. Arch. Environ. Contam. Toxicol. (1979) [Pubmed]
  10. Toxicity of pyrethroids and effect of synergists to larval and adult Helicoverpa zea, Spodoptera frugiperda, and Agrotis ipsilon (Lepidoptera: Noctuidae). Usmani, K.A., Knowles, C.O. J. Econ. Entomol. (2001) [Pubmed]
  11. Esterase-mediated bifenthrin resistance in a multiresistant strain of the two-spotted spider mite, Tetranychus urticae. Van Leeuwen, T., Tirry, L. Pest Manag. Sci. (2007) [Pubmed]
  12. Phase II multicenter trial of docetaxel, epirubicin, and 5-fluorouracil (DEF) in the treatment of advanced gastric cancer: a novel, safe, and active regimen. Murad, A.M., Skare, N.G., Vinholes, J., Lago, S., Pecego, R. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. (2006) [Pubmed]
  13. Effect of synergists on the oral and topical toxicity of azamethiphos to organophosphate-resistant houseflies (Diptera: Muscidae). Saito, K., Motoyama, N., Dauterman, W.C. J. Econ. Entomol. (1992) [Pubmed]
  14. Differential phosphorylation of c-Jun and JunD in response to the epidermal growth factor is determined by the structure of MAPK targeting sequences. Vinciguerra, M., Vivacqua, A., Fasanella, G., Gallo, A., Cuozzo, C., Morano, A., Maggiolini, M., Musti, A.M. J. Biol. Chem. (2004) [Pubmed]
  15. Functional analysis of the rice AP3 homologue OsMADS16 by RNA interference. Xiao, H., Wang, Y., Liu, D., Wang, W., Li, X., Zhao, X., Xu, J., Zhai, W., Zhu, L. Plant Mol. Biol. (2003) [Pubmed]
  16. The novel co-activator CRABPII binds to RARalpha and RXRalpha via two nuclear receptor interacting domains and does not require the AF-2 'core'. Bastie, J.N., Despouy, G., Balitrand, N., Rochette-Egly, C., Chomienne, C., Delva, L. FEBS Lett. (2001) [Pubmed]
  17. Molecular biology of flower development in Antirrhinum majus (snapdragon). Saedler, H., Huijser, P. Gene (1993) [Pubmed]
  18. Characterization of SaMADS D from Sinapis alba suggests a dual function of the gene: in inflorescence development and floral organogenesis. Bonhomme, F., Sommer, H., Bernier, G., Jacqmard, A. Plant Mol. Biol. (1997) [Pubmed]
  19. An analysis of the activators of single-chain urokinase-type plasminogen activator (scu-PA) in the dextran sulphate euglobulin fraction of normal plasma and of plasmas deficient in factor XII and prekallikrein. Binnema, D.J., Dooijewaard, G., Turion, P.N. Thromb. Haemost. (1991) [Pubmed]
  20. T-cell tolerance and autoimmune diabetes. Brumeanu, T.D., Bona, C.A., Casares, S. Int. Rev. Immunol. (2001) [Pubmed]
  21. Identification of a DEF-type docking domain for extracellular signal-regulated kinases 1/2 that directs phosphorylation and turnover of the BH3-only protein BimEL. Ley, R., Hadfield, K., Howes, E., Cook, S.J. J. Biol. Chem. (2005) [Pubmed]
  22. Organophosphate poisoning. Marrs, T.C. Pharmacol. Ther. (1993) [Pubmed]
  23. Mechanism of heparin activation of antithrombin: evidence for an induced-fit model of allosteric activation involving two interaction subsites. Desai, U.R., Petitou, M., Björk, I., Olson, S.T. Biochemistry (1998) [Pubmed]
  24. Designing small, nonsugar activators of antithrombin using hydropathic interaction analyses. Gunnarsson, G.T., Desai, U.R. J. Med. Chem. (2002) [Pubmed]
  25. Retinoic acid receptors interfere with the TGF-beta/Smad signaling pathway in a ligand-specific manner. Pendaries, V., Verrecchia, F., Michel, S., Mauviel, A. Oncogene (2003) [Pubmed]
  26. Valacyclovir for cytomegalovirus prophylaxis reduces the risk of acute renal allograft rejection. Reischig, T., Jindra, P., Mares, J., Cechura, M., Svecová, M., Hes, O., Opatrný, K., Treska, V. Transplantation (2005) [Pubmed]
  27. Soluble, dimeric HLA DR4-peptide chimeras: an approach for detection and immunoregulation of human type-1 diabetes. Preda, I., McEvoy, R.C., Lin, M., Bona, C.A., Rapaport, R., Brumeanu, T.D., Casares, S. Eur. J. Immunol. (2005) [Pubmed]
  28. Anterior cervical discectomy with and without fusion. A prospective study. Rosenørn, J., Hansen, E.B., Rosenørn, M.A. J. Neurosurg. (1983) [Pubmed]
 
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