Gene Review:
GLA - galactosidase, alpha
Homo sapiens
Synonyms:
Alpha-D-galactosidase A, Alpha-D-galactoside galactohydrolase, Alpha-galactosidase A, GALA, Melibiase
- Fabry disease: identification of novel alpha-galactosidase A mutations and molecular carrier detection by use of fluorescent chemical cleavage of mismatches. Germain, D.P., Poenaru, L. Biochem. Biophys. Res. Commun. (1999)
- Fabry disease: 20 novel GLA mutations in 35 families. Blaydon, D., Hill, J., Winchester, B. Hum. Mutat. (2001)
- Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study. Morita, H., Larson, M.G., Barr, S.C., Vasan, R.S., O'Donnell, C.J., Hirschhorn, J.N., Levy, D., Corey, D., Seidman, C.E., Seidman, J.G., Benjamin, E.J. Circulation (2006)
- Treatment of diabetic neuropathy with gamma-linolenic acid. The gamma-Linolenic Acid Multicenter Trial Group. Keen, H., Payan, J., Allawi, J., Walker, J., Jamal, G.A., Weir, A.I., Henderson, L.M., Bissessar, E.A., Watkins, P.J., Sampson, M. Diabetes Care (1993)
- Activation by synthetic lipid A subunit analogues (GLA compounds) of tumoricidal properties in human blood monocytes. Maeda, H., Saiki, I., Yamamoto, N., Takahashi, T., Sekiguchi, S., Kiso, M., Hasegawa, A., Azuma, I. Vaccine (1990)
- Osteocalcin induces chemotaxis, secretion of matrix proteins, and calcium-mediated intracellular signaling in human osteoclast-like cells. Chenu, C., Colucci, S., Grano, M., Zigrino, P., Barattolo, R., Zambonin, G., Baldini, N., Vergnaud, P., Delmas, P.D., Zallone, A.Z. J. Cell Biol. (1994)
- Fabry disease: isolation of a cDNA clone encoding human alpha-galactosidase A. Calhoun, D.H., Bishop, D.F., Bernstein, H.S., Quinn, M., Hantzopoulos, P., Desnick, R.J. Proc. Natl. Acad. Sci. U.S.A. (1985)
- Frequency of reactivation and variability in expression of X-linked enzyme loci. Mohandas, T., Sparkes, R.S., Bishop, D.F., Desnick, R.J., Shapiro, L.J. Am. J. Hum. Genet. (1984)
- Somatic mutations of the L12a gene in V-kappa(1) light chain deposition disease: potential effects on aberrant protein conformation and deposition. Vidal, R., Goñi, F., Stevens, F., Aucouturier, P., Kumar, A., Frangione, B., Ghiso, J., Gallo, G. Am. J. Pathol. (1999)
- Structural determinants of the factor IX molecule mediating interaction with the endothelial cell binding site are distinct from those involved in phospholipid binding. Ryan, J., Wolitzky, B., Heimer, E., Lambrose, T., Felix, A., Tam, J.P., Huang, L.H., Nawroth, P., Wilner, G., Kisiel, W. J. Biol. Chem. (1989)
- Gamma-carboxyglutamic acid in urine of newborn infants. Sann, L., Leclercq, M., Fouillit, M., Chapuis, M.C., Bruyère, A. Clin. Chim. Acta (1984)
- The use of gamma-linolenic acid in diabetic neuropathy. Horrobin, D.F. Agents Actions Suppl. (1992)
- Comparison of the effects of agalsidase alfa and agalsidase beta on cultured human Fabry fibroblasts and Fabry mice. Sakuraba, H., Murata-Ohsawa, M., Kawashima, I., Tajima, Y., Kotani, M., Ohshima, T., Chiba, Y., Takashiba, M., Jigami, Y., Fukushige, T., Kanzaki, T., Itoh, K. J. Hum. Genet. (2006)
- Enzyme replacement therapy in Fabry disease. Brady, R.O., Murray, G.J., Moore, D.F., Schiffmann, R. J. Inherit. Metab. Dis. (2001)
- Physical mapping shows close linkage between the alpha-galactosidase A gene (GLA) and the DXS178 locus. Vetrie, D., Bentley, D., Bobrow, M., Harris, A. Hum. Genet. (1993)
- Physical mapping in the region of the Bruton's tyrosine kinase and alpha-galactosidase A gene loci in proximal Xq22. Sweatman, A.K., Bradley, L.A., Lovering, R.C., O'Reilly, M.A., Levinsky, R.J., Kinnon, C. Hum. Genet. (1994)
- Comparison of health-related quality of life between heterozygous women with Fabry disease, a healthy control population, and patients with other chronic disease. Street, N.J., Yi, M.S., Bailey, L.A., Hopkin, R.J. Genet. Med. (2006)
- High level expression and export of beta-glucuronidase from murine mucopolysaccharidosis VII cells corrected by a double-copy retrovirus vector. Wolfe, J.H., Kyle, J.W., Sands, M.S., Sly, W.S., Markowitz, D.G., Parente, M.K. Gene Ther. (1995)
- Relationship between X-inactivation and clinical involvement in Fabry heterozygotes. Eleven novel mutations in the alpha-galactosidase A gene in the Czech and Slovak population. Dobrovolny, R., Dvorakova, L., Ledvinova, J., Magage, S., Bultas, J., Lubanda, J.C., Elleder, M., Karetova, D., Pavlikova, M., Hrebicek, M. J. Mol. Med. (2005)
- Dose-response effects of dietary gamma-linolenic acid-enriched oils on human polymorphonuclear-neutrophil biosynthesis of leukotriene B4. Ziboh, V.A., Fletcher, M.P. Am. J. Clin. Nutr. (1992)
- Synergistic interaction between vinorelbine and gamma-linolenic acid in breast cancer cells. Menéndez, J.A., Ropero, S., del Barbacid, M.M., Montero, S., Solanas, M., Escrich, E., Cortés-Funes, H., Colomer, R. Breast Cancer Res. Treat. (2002)
- Fatty acids, the immune response, and autoimmunity: a question of n-6 essentiality and the balance between n-6 and n-3. Harbige, L.S. Lipids (2003)
- Impaired carboxylation of osteocalcin in warfarin-treated patients. Menon, R.K., Gill, D.S., Thomas, M., Kernoff, P.B., Dandona, P. J. Clin. Endocrinol. Metab. (1987)
- Homologous radioimmunoassay of human osteocalcin. Bouillon, R., Vanderschueren, D., Van Herck, E., Nielsen, H.K., Bex, M., Heyns, W., Van Baelen, H. Clin. Chem. (1992)
- Bone mineral content of women receiving tamoxifen for mastalgia. Fentiman, I.S., Caleffi, M., Rodin, A., Murby, B., Fogelman, I. Br. J. Cancer (1989)
- Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) enhances docetaxel (Taxotere) cytotoxicity in human breast carcinoma cells: Relationship to lipid peroxidation and HER-2/neu expression. Menendez, J.A., Ropero, S., Lupu, R., Colomer, R. Oncol. Rep. (2004)
- Regional localization of alpha-galactosidase (GLA) to Xpter----q22, hexosaminidase B (HEXB) to 5q13----qter, and arylsulfatase B (ARSB) to 5pter----q13. Fox, M.F., DuToit, D.L., Warnich, L., Retief, A.E. Cytogenet. Cell Genet. (1984)
- Gene mutations in apical hypertrophic cardiomyopathy. Arad, M., Penas-Lado, M., Monserrat, L., Maron, B.J., Sherrid, M., Ho, C.Y., Barr, S., Karim, A., Olson, T.M., Kamisago, M., Seidman, J.G., Seidman, C.E. Circulation (2005)
- Low serum bone gamma-carboxyglutamic acid protein concentrations in patients with cystic fibrosis: correlation with hormonal parameters and bone mineral density. De Schepper, J., Smitz, J., Dab, I., Piepsz, A., Jonckheer, M., Bergmann, P. Horm. Res. (1993)
- Binding of gelatinases A and B to type-I collagen and other matrix components. Allan, J.A., Docherty, A.J., Barker, P.J., Huskisson, N.S., Reynolds, J.J., Murphy, G. Biochem. J. (1995)
- Evidence that free gamma carboxyglutamic acid circulates in serum. Fournier, B., Gineyts, E., Delmas, P.D. Clin. Chim. Acta (1989)
- Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. Menendez, J.A., Vellon, L., Colomer, R., Lupu, R. J. Natl. Cancer Inst. (2005)
- Enzyme replacement therapy of Fabry disease. Clarke, J.T., Iwanochko, R.M. Mol. Neurobiol. (2005)