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IL17C  -  interleukin 17C

Homo sapiens

Synonyms: CX2, Cytokine CX2, IL-17C, IL-21, Interleukin-17C, ...
 
 
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Disease relevance of IL17C

 

High impact information on IL17C

  • IL-17B mRNA is expressed in adult pancreas, small intestine, and stomach, whereas IL-17C mRNA is not detected by RNA blot hybridization of several adult tissues [4].
  • We have cloned and expressed two novel human cytokines, IL-17B and IL-17C, that are related to IL-17 ( approximately 27% amino acid identity) [4].
  • No expression of IL-17B or IL-17C mRNA is found in activated T cells [4].
  • CX+/CX- and Colo+/Colo- tumor sublines with stable heat shock protein 70 (Hsp70) high and low membrane expression were generated by fluorescence activated cell sorting of the parental human colon (CX2) and pancreas (Colo357) carcinoma cell lines, using an Hsp70-specific antibody [5].
  • IL-21 is a cytokine produced by CD4(+) T cells that has been reported to regulate human, as well as, mouse T and NK cell function and to inhibit Ag-induced IgE production by mouse B cells [6].
 

Biological context of IL17C

 

Anatomical context of IL17C

  • In a survey of cytokine induction, IL-17B and IL-17C stimulate the release of tumor necrosis factor alpha and IL-1beta from the monocytic cell line, THP-1, whereas IL-17 has only a weak effect in this system [4].
  • IL-21 Inhibits IFN-{gamma} Production in Developing Th1 Cells through the Repression of Eomesodermin Expression [10].
  • IL-21 also enhanced NK cell lytic activity against Ab-coated tumor cells [1].
  • A pig interleukin-21 (IL-21) cDNA was successfully cloned and sequenced from porcine peripheral blood lymphocytes (PBL) stimulated with 10 microg/ml concanavalin A (ConA), 10 microg/ml phytohemagglutinin P (PHA), 50 ng/ml phorbol 12-myristate 13-acetate (PMA), and 0.5 microg/ml anti-porcine CD3 antibody for 48 hr [11].
  • These data indicate that IL-21R is overexpressed in the inflamed synovial membrane and in peripheral blood or synovial fluid leukocytes of RA patients, and that IL-21 enhances local T-cell activation, proliferation and proinflammatory cytokine secretion [12].
 

Analytical, diagnostic and therapeutic context of IL17C

  • We made use of an in vivo-like co-culture model of multicellular tumour spheroids of three colon carcinoma cell lines (HRT-18, HT-29, CX-2) and three functionally different phenotypes of human macrophages (27E10, RM3/1, 25F9) to investigate if tumour cells deactivate macrophage cytotoxicity [13].
  • Three types of regression curves, namely, linear regression (Y = A + BX), second-degree regression (Y = A + BX + CX2), and asymptotic regression (Y = alpha + betapx), are discussed as possible models for the rewarming process following cold therapy [14].

References

  1. Interleukin-21 enhances NK cell activation in response to antibody-coated targets. Roda, J.M., Parihar, R., Lehman, A., Mani, A., Tridandapani, S., Carson, W.E. J. Immunol. (2006) [Pubmed]
  2. New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. Hurst, S.D., Muchamuel, T., Gorman, D.M., Gilbert, J.M., Clifford, T., Kwan, S., Menon, S., Seymour, B., Jackson, C., Kung, T.T., Brieland, J.K., Zurawski, S.M., Chapman, R.W., Zurawski, G., Coffman, R.L. J. Immunol. (2002) [Pubmed]
  3. Autoimmunity during lymphopenia: a two-hit model. Krupica, T., Fry, T.J., Mackall, C.L. Clin. Immunol. (2006) [Pubmed]
  4. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. Li, H., Chen, J., Huang, A., Stinson, J., Heldens, S., Foster, J., Dowd, P., Gurney, A.L., Wood, W.I. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells. Gehrmann, M., Marienhagen, J., Eichholtz-Wirth, H., Fritz, E., Ellwart, J., Jäättelä, M., Zilch, T., Multhoff, G. Cell Death Differ. (2005) [Pubmed]
  6. IFN-{gamma}-Mediated Inhibition of Human IgE Synthesis by IL-21 Is Associated with a Polymorphism in the IL-21R Gene. P??ne, J., Guglielmi, L., Gauchat, J.F., Harrer, N., Woisetschl??ger, M., Boulay, V., Fabre, J.M., Demoly, P., Yssel, H. J. Immunol. (2006) [Pubmed]
  7. Identification of Cellular Intermediates and Molecular Pathways Induced by IL-21 in Human B Cells. Konforte, D., Paige, C.J. J. Immunol. (2006) [Pubmed]
  8. Heat shock protein 72 on tumor cells: a recognition structure for natural killer cells. Multhoff, G., Botzler, C., Jennen, L., Schmidt, J., Ellwart, J., Issels, R. J. Immunol. (1997) [Pubmed]
  9. Search for genetic factors associated with susceptibility to multiple sclerosis. Forte, G.I., Ragonese, P., Salemi, G., Scola, L., Candore, G., D'Amelio, M., Crivello, A., Di Benedetto, N., Nuzzo, D., Giacalone, A., Lio, D., Caruso, C. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  10. IL-21 Inhibits IFN-{gamma} Production in Developing Th1 Cells through the Repression of Eomesodermin Expression. Suto, A., Wurster, A.L., Reiner, S.L., Grusby, M.J. J. Immunol. (2006) [Pubmed]
  11. Molecular cloning, chromosomal location, and biological activity of porcine interleukin-21. Muneta, Y., Kikuma, R., Uenishi, H., Hoshino, T., Yoshihara, K., Tanaka, M., Hamashima, N., Mori, Y. J. Vet. Med. Sci. (2004) [Pubmed]
  12. Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis. Li, J., Shen, W., Kong, K., Liu, Z. Scand. J. Immunol. (2006) [Pubmed]
  13. Suppression of the reactive oxygen intermediates production of human macrophages by colorectal adenocarcinoma cell lines. Siegert, A., Denkert, C., Leclere, A., Hauptmann, S. Immunology (1999) [Pubmed]
  14. Mathematical modeling of rewarming after cold therapy. Avet, L.M. Physical therapy. (1978) [Pubmed]
 
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