Gene Review:
Nbn - nibrin
Mus musculus
Synonyms:
Cell cycle regulatory protein p95, Nbs1, Nibrin, Nijmegen breakage syndrome protein 1 homolog
- An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Frappart, P.O., Tong, W.M., Demuth, I., Radovanovic, I., Herceg, Z., Aguzzi, A., Digweed, M., Wang, Z.Q. Nat. Med. (2005)
- Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis. Dumon-Jones, V., Frappart, P.O., Tong, W.M., Sajithlal, G., Hulla, W., Schmid, G., Herceg, Z., Digweed, M., Wang, Z.Q. Cancer Res. (2003)
- A novel function of DNA repair molecule Nbs1 in terminal differentiation of the lens fibre cells and cataractogenesis. Yang, Y.G., Frappart, P.O., Frappart, L., Wang, Z.Q., Tong, W.M. DNA Repair (Amst.) (2006)
- AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Petersen, S., Casellas, R., Reina-San-Martin, B., Chen, H.T., Difilippantonio, M.J., Wilson, P.C., Hanitsch, L., Celeste, A., Muramatsu, M., Pilch, D.R., Redon, C., Ried, T., Bonner, W.M., Honjo, T., Nussenzweig, M.C., Nussenzweig, A. Nature (2001)
- Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. Hammond, E.M., Green, S.L., Giaccia, A.J. Mutat. Res. (2003)
- Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair. Alt, J.R., Bouska, A., Fernandez, M.R., Cerny, R.L., Xiao, H., Eischen, C.M. J. Biol. Chem. (2005)
- Nibrin functions in Ig class-switch recombination. Kracker, S., Bergmann, Y., Demuth, I., Frappart, P.O., Hildebrand, G., Christine, R., Wang, Z.Q., Sperling, K., Digweed, M., Radbruch, A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability. Demuth, I., Frappart, P.O., Hildebrand, G., Melchers, A., Lobitz, S., Stöckl, L., Varon, R., Herceg, Z., Sperling, K., Wang, Z.Q., Digweed, M. Hum. Mol. Genet. (2004)
- Identification, characterization, and mapping of a mouse homolog of the gene mutated in Nijmegen breakage syndrome. Vissinga, C.S., Yeo, T.C., Woessner, J., Massa, H.F., Wilson, R.K., Trask, B.J., Concannon, P. Cytogenet. Cell Genet. (1999)
- Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks. Yang, Y.G., Saidi, A., Frappart, P.O., Min, W., Barrucand, C., Dumon-Jones, V., Michelon, J., Herceg, Z., Wang, Z.Q. EMBO J. (2006)
- Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Difilippantonio, S., Celeste, A., Fernandez-Capetillo, O., Chen, H.T., Reina San Martin, B., Van Laethem, F., Yang, Y.P., Petukhova, G.V., Eckhaus, M., Feigenbaum, L., Manova, K., Kruhlak, M., Camerini-Otero, R.D., Sharan, S., Nussenzweig, M., Nussenzweig, A. Nat. Cell Biol. (2005)
- Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Bender, C.F., Sikes, M.L., Sullivan, R., Huye, L.E., Le Beau, M.M., Roth, D.B., Mirzoeva, O.K., Oltz, E.M., Petrini, J.H. Genes Dev. (2002)