High impact information on Dguok

• The broad specificity, restricted tissue distribution, and location of mouse dGK in multiple cellular compartments raise new considerations with respect to the role of the individual deoxynucleoside kinases in nucleotide metabolism [1].
• Recombinant mouse dGK showed similar specific activity and substrate specificity as compared with the human enzyme [1].
• Deoxyguanosine kinase (dGK) is a nuclear gene product that catalyzes the phosphorylation of purine deoxyribonucleosides and their analogues [1].
• TK2 was the limiting dNK activity while dGK was predominant in adipocytes and myocytes [2].
• Differentiated L6 myoblasts had lower activities of cytosolic dNK's and TMPK, higher dGK and similar TK2 and deoxyribonucleotidases (dNT) activities compared to proliferating myoblasts [2].

Associations of Dguok with chemical compounds

• Purification of deoxycytidine kinases from two P815 murine neoplasms and their separation from deoxyguanosine kinase [3].
• Deoxyguanosine kinase (ATP: deoxyguanosine 5'-phosphotransferase) activity has been identified in neonatal mouse skin tissue [4].

Other interactions of Dguok

• Adenosine kinase, deoxyguanosine kinase, and purine nucleoside phosphorylase exhibited less than 2-fold changes in activity between days 7 and 13 [5].

References