Gene Review:
Skp2 - S-phase kinase-associated protein 2 (p45)
Mus musculus
Synonyms:
4930500A04Rik, Cyclin-A/CDK2-associated protein p45, F-box protein Skp2, F-box/WD-40 protein 1, FBXL1, ...
- Knockdown of Skp2 by siRNA inhibits melanoma cell growth in vitro and in vivo. Katagiri, Y., Hozumi, Y., Kondo, S. J. Dermatol. Sci. (2006)
- Down-regulation of S-phase kinase associated protein 2 (Skp2) induces apoptosis in oral cancer cells. Harada, K., Supriatno, n.u.l.l., Kawashima, Y., Itashiki, Y., Yoshida, H., Sato, M. Oral Oncol. (2005)
- Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate. Shim, E.H., Johnson, L., Noh, H.L., Kim, Y.J., Sun, H., Zeiss, C., Zhang, H. Cancer Res. (2003)
- Gene therapy for human small-cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference. Sumimoto, H., Yamagata, S., Shimizu, A., Miyoshi, H., Mizuguchi, H., Hayakawa, T., Miyagishi, M., Taira, K., Kawakami, Y. Gene Ther. (2005)
- Skp2-dependent degradation of p27kip1 is essential for cell cycle progression. Kossatz, U., Dietrich, N., Zender, L., Buer, J., Manns, M.P., Malek, N.P. Genes Dev. (2004)
- A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. Spruck, C., Strohmaier, H., Watson, M., Smith, A.P., Ryan, A., Krek, T.W., Reed, S.I. Mol. Cell (2001)
- Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. Nakayama, K., Nagahama, H., Minamishima, Y.A., Matsumoto, M., Nakamichi, I., Kitagawa, K., Shirane, M., Tsunematsu, R., Tsukiyama, T., Ishida, N., Kitagawa, M., Nakayama, K., Hatakeyama, S. EMBO J. (2000)
- Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. Bornstein, G., Bloom, J., Sitry-Shevah, D., Nakayama, K., Pagano, M., Hershko, A. J. Biol. Chem. (2003)
- Antimitogenesis linked to regulation of Skp2 gene expression. Stewart, S.A., Kothapalli, D., Yung, Y., Assoian, R.K. J. Biol. Chem. (2004)
- Role of the F-box protein Skp2 in cell proliferation in the developing auditory system in mice. Dong, Y., Nakagawa, T., Endo, T., Kim, T.S., Iguchi, F., Yamamoto, N., Naito, Y., Ito, J. Neuroreport (2003)
- Skp2-mediated degradation of p27 regulates progression into mitosis. Nakayama, K., Nagahama, H., Minamishima, Y.A., Miyake, S., Ishida, N., Hatakeyama, S., Kitagawa, M., Iemura, S., Natsume, T., Nakayama, K.I. Dev. Cell (2004)
- Involvement of p27(KIP1) degradation by Skp2 in the regulation of proliferation in response to wounding of corneal epithelium. Yoshida, K., Nakayama, K., Nagahama, H., Harada, T., Harada, C., Imaki, J., Matsuda, A., Yamamoto, K., Ito, M., Ohno, S., Nakayama, K. Invest. Ophthalmol. Vis. Sci. (2002)
- Degradation of Tob1 Mediated by SCFSkp2-Dependent Ubiquitination. Hiramatsu, Y., Kitagawa, K., Suzuki, T., Uchida, C., Hattori, T., Kikuchi, H., Oda, T., Hatakeyama, S., Nakayama, K.I., Yamamoto, T., Konno, H., Kitagawa, M. Cancer Res. (2006)
- Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway. Hara, T., Kamura, T., Nakayama, K., Oshikawa, K., Hatakeyama, S., Nakayama, K. J. Biol. Chem. (2001)
- A novel route for connexin 43 to inhibit cell proliferation: negative regulation of S-phase kinase-associated protein (Skp 2). Zhang, Y.W., Nakayama, K., Nakayama, K., Morita, I. Cancer Res. (2003)
- Pro-IL-16 regulation in activated murine CD4+ lymphocytes. Ren, F., Zhan, X., Martens, G., Lee, J., Center, D., Hanson, S.K., Kornfeld, H. J. Immunol. (2005)
- Novel effect of helenalin on Akt signaling and Skp2 expression in 3T3-L1 preadipocytes. Auld, C.A., Hopkins, R.G., Fernandes, K.M., Morrison, R.F. Biochem. Biophys. Res. Commun. (2006)
- Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells. Zhong, L., Georgia, S., Tschen, S.I., Nakayama, K., Nakayama, K., Bhushan, A. J. Clin. Invest. (2007)
- Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice. Minamishima, Y.A., Nakayama, K., Nakayama, K. Cancer Res. (2002)
- Cell cycle-dependent regulation of the Skp2 promoter by GA-binding protein. Imaki, H., Nakayama, K., Delehouzee, S., Handa, H., Kitagawa, M., Kamura, T., Nakayama, K.I. Cancer Res. (2003)