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Gene Review

doc  -  death on curing

Enterobacteria phage P1

 
 
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Disease relevance of doc

 

High impact information on doc

 

Biological context of doc

  • The operon consists of a gene encoding an endotoxin responsible for death on curing (doc), preceded by a gene encoding a relatively unstable antidote that can prevent host death (phd) [4].
  • Electrophoretic mobility of DNA containing the promoter region was retarded in the presence of Phd and further retarded in the presence of Phd and Doc. When doc was co-expressed with phd, repression of the lacZ fusion was enhanced more than 100-fold [4].
 

Other interactions of doc

  • The upstream sequences include functional phd and doc genes, which encode an addiction system that stabilizes the P1 prophage state, and extend to and beyond pac, the site at which phage DNA packaging begins [5].

References

 
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