Disease relevance of RTD

• All the 200 Staphylococcus intermedius and 100 Staphylococcus hyicus strains were resistant to the used 58 phages at RTD [1].
• Renal tubular dysplasia is an autosomal recessive disease of Japanese black cattle characterized by renal failure and growth retardation [2].
• Renal tubular dysplasia is a hereditary disease of Japanese black cattle showing renal failure and growth retardation with an autosomal recessive trait [3].
• It was concluded that renal tubular dysplasia was the primary lesion of the disease, and that interstitial fibrosis and reductions in the numbers of nephrons were secondary lesions [4].
• Renal tubular dysplasia is an autosomal recessively inherited disorder in Japanese black cattle that is due to deletion mutations in the claudin-16 gene and causes chronic renal failure and death of affected animals [5].

High impact information on RTD

• Homozygosity mapping of the locus responsible for renal tubular dysplasia of cattle on bovine chromosome 1 [3].
• In cattle, total deficiency of claudin-16 causes severe renal tubular dysplasia without aberrant metabolic changes of divalent cations, suggesting that bovine claudin-16 has some roles in renal tubule formation and paracellular transport that are somewhat different from those expected from the pathology of human disease [6].
• Serum IGF-1 concentrations were lower normal or lower in cattle with RTD than in healthy cattle [7].
• Growth retardation in RTD might be associated partially with GH resistance [7].

References