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Gene Review: 

SV2A  -  synaptic vesicle glycoprotein 2A

Bos taurus

 
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High impact information on SV2

  • In contrast, the SV proteins synaptophysin, SV2, and p29 were restricted to the SV-containing fractions [1].
  • Synaptic vesicles exhibiting [3H]norepinephrine uptake comigrate with approximately 40-nm-diameter synaptic vesicles carrying SV2 or R10 antigens during permeation chromatography [2].
  • They were immunoreactive for SV2, VMAT2 and synaptobrevin II, which are all known to be highly enriched in large dense granules [3].
  • In adrenals most p65 and SV2 is confined to chromaffin granules [4].
 

Anatomical context of SV2

References

  1. Synaptotagmin: a membrane constituent of neuropeptide-containing large dense-core vesicles. Walch-Solimena, C., Takei, K., Marek, K.L., Midyett, K., Südhof, T.C., De Camilli, P., Jahn, R. J. Neurosci. (1993)
  2. Synaptic vesicles from mammalian brain: large-scale purification and physical and immunochemical characterization. Floor, E., Schaeffer, S.F., Feist, B.E., Leeman, S.E. J. Neurochem. (1988)
  3. Neurosecretory granule formation in ligated axons: additional arguments for a local differentiation from a Golgi apparatus extension. Quatacker, J.R. Histochem. J. (2001)
  4. Synaptin/synaptophysin, p65 and SV2: their presence in adrenal chromaffin granules and sympathetic large dense core vesicles. Schmidle, T., Weiler, R., Desnos, C., Scherman, D., Fischer-Colbrie, R., Floor, E., Winkler, H. Biochim. Biophys. Acta (1991)
 
 
 
 
 
 
 
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