Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

AIF1 - allograft inflammatory factor 1

Bos taurus

Synonyms: AIF-1, Allograft inflammatory factor 1

Koshiba, H. et al., Glover, M.D. et al., Fu, K. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of AIF1

Peritoneal macrophages from endometriosis patients secreted more AIF-1 than those from unaffected women (P < 0.05) [1].

High impact information on AIF1

Expression of allograft inflammatory factor-1 in human eutopic endometrium and endometriosis: possible association with progression of endometriosis [1].
AIF-1 release from macrophages was stimulated by IL-1beta (P < 0.01) and interferon-gamma (P < 0.05) [1].
AIF-1 derived from peritoneal macrophages may also possibly play a significant role in the pathophysiology and progression of endometriosis [1].
Expression has also been shown in human placentas and bovine embryos, suggesting that AIF-1 may be involved in reproductive function [1].
AIF-1 protein was present in greater amounts in peritoneal fluid from patients with endometriosis than in women without it (P < 0.01), and its concentration correlated with the Revised American Society for Reproductive Medicine score (rs = 0.693; P < 0.0001) [1].

Biological context of AIF1

AIF-1 mRNA was present in developing placenta through Gestation Day 36, and abundant levels were observed in adult bovine spleen and lung [2].
These results demonstrate for the first time that AIF-1 is expressed in eutopic endometrium and endometriotic tissue, suggesting that AIF-1 is one cytokine in the local network involved in the onset of menstruation [1].
Daintain is highly similar in amino acid sequence to allograft inflammatory factor-1 (AIF-1) [3].

Analytical, diagnostic and therapeutic context of AIF1

RT-PCR, Western blot analysis, and immunohistochemistry showed that AIF-1 mRNA and protein were expressed both in eutopic endometrium and in endometriotic tissue [1].
Allograft inflammatory factor-1 (AIF-1) is a cytokine originally identified in rat cardiac allografts with chronic rejection [1].

References

Expression of allograft inflammatory factor-1 in human eutopic endometrium and endometriosis: possible association with progression of endometriosis. Koshiba, H., Kitawaki, J., Teramoto, M., Kitaoka, Y., Ishihara, H., Obayashi, H., Ohta, M., Hara, H., Adachi, T., Honjo, H. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
Increased messenger RNA for allograft inflammatory factor-1, LERK-5, and a novel gene in 17.5-day relative to 15.5-day bovine embryos. Glover, M.D., Seidel, G.E. Biol. Reprod. (2003) [Pubmed]
Preparation and identification of monoclonal antibodies against daintain. Fu, K., Zhao, Y.Y., Tang, W.X., Zhong, Y., Yang, T.B., Wang, J.H. Hybridoma (2005) (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use

[search][advanced]