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Gene Review: 

DNMT1  -  DNA (cytosine-5-)-methyltransferase 1

Bos taurus

Synonyms: DNA (cytosine-5)-methyltransferase 1, Dnmt1
 
 
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High impact information on DNMT1

  • In experiment 4, the RA of DNMT transcripts was decreased in in vivo-derived blastocysts compared to those produced in vitro [1].
  • Relative abundance of DNMT1 in SCNT embryos derived from fetal fibroblasts was increased, and IF-tau expression in SCNT embryos derived from cumulus cells was increased [2].
  • The Bax, E-cad, IF-tau, Hsp (heat shock protein) 70, Igf2r (insulin-like growth factor 2 receptor), DNMT (DNA methyltransferase) 1 and Mash (mammalian achaete-scute homologue) 2 genes were selected for gene expression analysis [2].
  • Bovine Dnmt mRNAs display strong sequence homology to those of human and mouse and similar to other species, exist as multiple isoforms [3].

References

  1. Nuclear transfer protocol affects messenger RNA expression patterns in cloned bovine blastocysts. Wrenzycki, C., Wells, D., Herrmann, D., Miller, A., Oliver, J., Tervit, R., Niemann, H. Biol. Reprod. (2001) [Pubmed]
  2. Developmental competence and gene expression in preimplantation bovine embryos derived from somatic cell nuclear transfer using different donor cells. Jang, G., Jeon, H.Y., Ko, K.H., Park, H.J., Kang, S.K., Lee, B.C., Hwang, W.S. Zygote (2005) [Pubmed]
  3. Analysis of DNA (cytosine 5) methyltransferase mRNA sequence and expression in bovine preimplantation embryos, fetal and adult tissues. Golding, M.C., Westhusin, M.E. Gene Expr. Patterns (2003) [Pubmed]
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