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Gene Review:

PIGR - polymeric immunoglobulin receptor

Bos taurus

Synonyms: PIgR, Poly-Ig receptor, Polymeric immunoglobulin receptor

Kulseth, M.A. et al., Kulseth, M.A. et al., Ng, T.B. et al., Hunziker, W. et al., Phillips-Quagliata, J.M. et al., et al.

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Disease relevance of PIGR

The polymeric immunoglobulin receptor-like milk protein inhibited HIV-1 reverse transcriptase (RT) with an IC(50) of 4.8 microM [1].
A polymeric immunoglobulin receptor-like milk protein with inhibitory activity on human immunodeficiency virus type 1 reverse transcriptase [1].

High impact information on PIGR

Although BFA has been thought to act only on biosynthetic organelles, we now show that this drug also reversibly blocks polymeric immunoglobulin receptor-mediated transcytosis in MDCK cells [2].
Adaptor binding was partially inhibited by soluble peptides representing the cytoplasmic domains of the asialoglycoprotein receptor and the polymeric immunoglobulin receptor [3].
Inasmuch as this mouse B cell pIgR binds IgM better than IgA, it is similar to human pIgR and differs from rat, mouse, and rabbit epithelial cell pIgRs that bind IgA but not IgM [4].
The polymeric immunoglobulin receptor (transmembrane secretory component) mediates transcellular transport of dimeric immunoglobulin A (IgA) and pentameric IgM in glandular and mucosal epithelial cells. cDNAs encoding two forms of the bovine polymeric immunoglobulin receptor (pIgR) have been cloned and sequenced [5].
Polymeric immunoglobulin receptor (PIGR) mediates transcellular transport of secretory antibodies in glandular and mucosal epithelial cells [6].

Biological context of PIGR

Using in situ hybridization, PIGR was localized to bovine chromosome 16, segment q13, thus confirming the recent assignment of syntenic group U1 to this chromosome [6].

Anatomical context of PIGR

By use of a bovine-rodent somatic cell hybrid panel the bovine PIGR locus has been assigned to syntenic group U1 [6].

Analytical, diagnostic and therapeutic context of PIGR

In Northern blot analysis of various bovine tissues, only the long form of pIgR mRNA was detected [5].
Direct PCR sequencing of a segment in the PIGR coding region (nucleotides 162-413) from 13 bulls of Norwegian Cattle revealed single nucleotide exchanges at two positions [6].

References

A polymeric immunoglobulin receptor-like milk protein with inhibitory activity on human immunodeficiency virus type 1 reverse transcriptase. Ng, T.B., Ye, X.Y. Int. J. Biochem. Cell Biol. (2004) [Pubmed]
Selective inhibition of transcytosis by brefeldin A in MDCK cells. Hunziker, W., Whitney, J.A., Mellman, I. Cell (1991) [Pubmed]
Adaptor self-aggregation, adaptor-receptor recognition and binding of alpha-adaptin subunits to the plasma membrane contribute to recruitment of adaptor (AP2) components of clathrin-coated pits. Chang, M.P., Mallet, W.G., Mostov, K.E., Brodsky, F.M. EMBO J. (1993) [Pubmed]
The IgA/IgM receptor expressed on a murine B cell lymphoma is poly-Ig receptor. Phillips-Quagliata, J.M., Patel, S., Han, J.K., Arakelov, S., Rao, T.D., Shulman, M.J., Fazel, S., Corley, R.B., Everett, M., Klein, M.H., Underdown, B.J., Corthésy, B. J. Immunol. (2000) [Pubmed]
Cloning and characterization of two forms of bovine polymeric immunoglobulin receptor cDNA. Kulseth, M.A., Krajci, P., Myklebost, O., Rogne, S. DNA Cell Biol. (1995) [Pubmed]
Chromosomal localization and detection of DNA polymorphisms in the bovine polymeric immunoglobulin receptor gene. Kulseth, M.A., Toldo, S.S., Fries, R., Womack, J., Lien, S., Rogne, S. Anim. Genet. (1994) [Pubmed]

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