The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.
wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review: 

SMC1A  -  structural maintenance of chromosomes 1A

Bos taurus

Synonyms: SMC protein 1A, SMC-1A, SMC1, SMC1L1, Structural maintenance of chromosomes protein 1A
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on SMC1L1

  • SMC proteins are involved in mitotic chromosome segregation and condensation, as well as in certain DNA repair pathways in fission (rad18 gene) and budding (RHC18 gene) yeast [1].
  • DNA interaction and dimerization of eukaryotic SMC hinge domains [2].
  • The eukaryotic SMC1/SMC3 heterodimer is essential for sister chromatid cohesion and acts in DNA repair and recombination [2].
  • Analysis of bovine SMC1 and SMC3 protein domains now reveals that not only the C-terminal domains, but also the coiled-coil region, binds DNA, while the N terminus is inactive [3].
  • Members of the evolutionary conserved Structural Maintenance of Chromosomes (SMC) protein family are involved in chromosome condensation and gene dosage compensation with the SMC2 and SMC4 subtypes, and sister chromatid cohesion with the SMC1 and SMC3 subtypes [4].
 

Biological context of SMC1L1

 

Other interactions of SMC1L1

  • Cloning and characterization of mammalian SMC1 and SMC3 genes and proteins, components of the DNA recombination complexes RC-1 [4].
 

Analytical, diagnostic and therapeutic context of SMC1L1

References

  1. SMC proteins constitute two subunits of the mammalian recombination complex RC-1. Jessberger, R., Riwar, B., Baechtold, H., Akhmedov, A.T. EMBO J. (1996) [Pubmed]
  2. DNA interaction and dimerization of eukaryotic SMC hinge domains. Chiu, A., Revenkova, E., Jessberger, R. J. Biol. Chem. (2004) [Pubmed]
  3. Mammalian SMC3 C-terminal and coiled-coil protein domains specifically bind palindromic DNA, do not block DNA ends, and prevent DNA bending. Akhmedov, A.T., Gross, B., Jessberger, R. J. Biol. Chem. (1999) [Pubmed]
  4. Cloning and characterization of mammalian SMC1 and SMC3 genes and proteins, components of the DNA recombination complexes RC-1. Stursberg, S., Riwar, B., Jessberger, R. Gene (1999) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Use
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt
  • Ensembl

Table of contents

About

Terms

 

WikiGenes - Universities