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Ugt2b1  -  UDP glucuronosyltransferase 2 family,...

Rattus norvegicus

Synonyms: 2B1, UDP-glucuronosyltransferase 2B1, UDPGT 2B1, UDPGTr-2, Udpgtr2, ...
 
 
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Biological context of Udpgtr2

 

Anatomical context of Udpgtr2

 

Associations of Udpgtr2 with chemical compounds

  • However, morphine UDPGT was not induced by phenobarbital, suggesting that obese Zucker rats may possess a defect in the induction of this enzyme similar to that already described for the CYP2B gene in this strain [4].
  • The mutation was found not only to be located in the region where bilirubin UDPGT cDNA shared an identical sequence with 3-methylcholanthrene (3M C)-inducible UDPGT cDNA but also to occur in the same position on the two cDNAs from the mutant rat [5].
  • Cytochrome P-450 (P-450) content as well as p-nitroanisole (pNA) O-demethylase and UDP-glucuronyltransferase (UDPGT) activities were determined in livers of middle-aged (MA; 12 or 18 months) and aged (24-26 months) rats exercised by either treadmill running or swimming [7].
  • The effects of a vitamin E (VE) deficient diet given for 120 days on total cytochrome P450 (P450) contents and UDP-glucuronyl transferase (UDPGT) and sulfotransferase (ST) activities were investigated in rat liver of both sexes [8].
  • 4. Both DAS and DADS increased the activity of GST and p-nitrophenol UDP-glucuronyltransferase (UDPGT 1), whereas UDPGT 2 activity was enhanced only by DAS [9].

References

  1. Organization of the rat UDP-glucuronosyltransferase, UDPGTr-2, gene and characterization of its promoter. Mackenzie, P.I., Rodbourn, L. J. Biol. Chem. (1990) [Pubmed]
  2. Rat liver UDP-glucuronosyltransferase. Identification of cDNAs encoding two enzymes which glucuronidate testosterone, dihydrotestosterone, and beta-estradiol. Mackenzie, P.I. J. Biol. Chem. (1987) [Pubmed]
  3. Hemin administration to rats reduces levels of hepatic mRNAs for phenobarbitone-inducible enzymes. Srivastava, G., Hansen, A.J., Bawden, M.J., May, B.K. Mol. Pharmacol. (1990) [Pubmed]
  4. Effect of genetic obesity and phenobarbital treatment on the hepatic conjugation pathways. Chaudhary, I.P., Tuntaterdtum, S., McNamara, P.J., Robertson, L.W., Blouin, R.A. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  5. Genetic defect of bilirubin UDP-glucuronosyltransferase in the hyperbilirubinemic Gunn rat. Sato, H., Aono, S., Kashiwamata, S., Koiwai, O. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  6. Effect of donor strains and age of the recipient in the use of microencapsulated hepatocytes to control hyperbilirubinemia in the Gunn rat. Bruni, S., Chang, T.M. The International journal of artificial organs. (1995) [Pubmed]
  7. Differential effects of swimming and running on microsomal metabolism in middle-aged and aged Fischer 344 rats. Day, W.W., Chesky, J.A., Weiner, M. Mech. Ageing Dev. (1992) [Pubmed]
  8. Effects of vitamin E deficiency on hepatic microsomal cytochrome P450 and phase II enzymes in male and female rats. Iwasaki, M., Iwama, M., Miyata, N., Iitoi, Y., Kanke, Y. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1994) [Pubmed]
  9. Modification of hepatic drug-metabolizing enzymes in rat fed naturally occurring allyl sulphides. Haber, D., Siess, M.H., de Waziers, I., Beaune, P., Suschetet, M. Xenobiotica (1994) [Pubmed]
 
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