Gene Review:
NOS3 - nitric oxide synthase 3 (endothelial cell)
Bos taurus
- Cyclosporin A inhibits flow-mediated activation of endothelial nitric-oxide synthase by altering cholesterol content in caveolae. Lungu, A.O., Jin, Z.G., Yamawaki, H., Tanimoto, T., Wong, C., Berk, B.C. J. Biol. Chem. (2004)
- Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells. Anderson, H.D., Rahmutula, D., Gardner, D.G. J. Biol. Chem. (2004)
- Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. Du, X.L., Edelstein, D., Dimmeler, S., Ju, Q., Sui, C., Brownlee, M. J. Clin. Invest. (2001)
- Endothelial cytosolic proteins bind to the 3' untranslated region of endothelial nitric oxide synthase mRNA: regulation by tumor necrosis factor alpha. Alonso, J., Sánchez de Miguel, L., Montón, M., Casado, S., López-Farré, A. Mol. Cell. Biol. (1997)
- Overexpression of endothelial nitric oxide synthase in transgenic mice accelerates testicular germ cell apoptosis induced by experimental cryptorchidism. Ishikawa, T., Kondo, Y., Goda, K., Fujisawa, M. J. Androl. (2005)
- Regulation of endothelial nitric oxide synthase gene expression by oxidized linoleic acid. Ramasamy, S., Parthasarathy, S., Harrison, D.G. J. Lipid Res. (1998)
- Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center. Raman, C.S., Li, H., Martásek, P., Král, V., Masters, B.S., Poulos, T.L. Cell (1998)
- Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. Zou, M.H., Shi, C., Cohen, R.A. J. Clin. Invest. (2002)
- Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids. Limbourg, F.P., Huang, Z., Plumier, J.C., Simoncini, T., Fujioka, M., Tuckermann, J., Schütz, G., Moskowitz, M.A., Liao, J.K. J. Clin. Invest. (2002)
- Diabetic mouse angiopathy is linked to progressive sympathetic receptor deletion coupled to an enhanced caveolin-1 expression. Bucci, M., Roviezzo, F., Brancaleone, V., Lin, M.I., Di Lorenzo, A., Cicala, C., Pinto, A., Sessa, W.C., Farneti, S., Fiorucci, S., Cirino, G. Arterioscler. Thromb. Vasc. Biol. (2004)
- Opposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveolae. Peterson, T.E., Poppa, V., Ueba, H., Wu, A., Yan, C., Berk, B.C. Circ. Res. (1999)
- Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation. Rodríguez-Crespo, I., Gerber, N.C., Ortiz de Montellano, P.R. J. Biol. Chem. (1996)
- Regulation of endothelial nitric oxide synthase by protein kinase C. Matsubara, M., Hayashi, N., Jing, T., Titani, K. J. Biochem. (2003)
- Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin. Michel, J.B., Feron, O., Sacks, D., Michel, T. J. Biol. Chem. (1997)
- Direct interaction between endothelial nitric-oxide synthase and dynamin-2. Implications for nitric-oxide synthase function. Cao, S., Yao, J., McCabe, T.J., Yao, Q., Katusic, Z.S., Sessa, W.C., Shah, V. J. Biol. Chem. (2001)
- Endothelial nitric oxide synthase and its negative regulator caveolin-1 localize to distinct perinuclear organelles. Govers, R., van der Sluijs, P., van Donselaar, E., Slot, J.W., Rabelink, T.J. J. Histochem. Cytochem. (2002)
- The proline-rich domain of dynamin-2 is responsible for dynamin-dependent in vitro potentiation of endothelial nitric-oxide synthase activity via selective effects on reductase domain function. Cao, S., Yao, J., Shah, V. J. Biol. Chem. (2003)
- TNF-alpha inhibits flow and insulin signaling leading to NO production in aortic endothelial cells. Kim, F., Gallis, B., Corson, M.A. Am. J. Physiol., Cell Physiol. (2001)
- Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides. Bernatchez, P.N., Bauer, P.M., Yu, J., Prendergast, J.S., He, P., Sessa, W.C. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo. García-Cardeña, G., Martasek, P., Masters, B.S., Skidd, P.M., Couet, J., Li, S., Lisanti, M.P., Sessa, W.C. J. Biol. Chem. (1997)
- Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells. Chen, Y., Medhora, M., Falck, J.R., Pritchard, K.A., Jacobs, E.R. Am. J. Physiol. Lung Cell Mol. Physiol. (2006)
- Cerivastatin prevents tumor necrosis factor-alpha-induced downregulation of endothelial nitric oxide synthase: role of endothelial cytosolic proteins. González-Fernández, F., Jiménez, A., López-Blaya, A., Velasco, S., Arriero, M.M., Celdrán, A., Rico, L., Farré, J., Casado, S., López-Farré, A. Atherosclerosis (2001)
- Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002. Gallis, B., Corthals, G.L., Goodlett, D.R., Ueba, H., Kim, F., Presnell, S.R., Figeys, D., Harrison, D.G., Berk, B.C., Aebersold, R., Corson, M.A. J. Biol. Chem. (1999)
- VEGF-induced permeability increase is mediated by caveolae. Feng, Y., Venema, V.J., Venema, R.C., Tsai, N., Behzadian, M.A., Caldwell, R.B. Invest. Ophthalmol. Vis. Sci. (1999)
- Hepatocyte growth factor activates endothelial nitric oxide synthase by Ca(2+)- and phosphoinositide 3-kinase/Akt-dependent phosphorylation in aortic endothelial cells. Makondo, K., Kimura, K., Kitamura, N., Kitamura, T., Yamaji, D., Jung, B.D., Saito, M. Biochem. J. (2003)
- Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide. Cai, H., Li, Z., Davis, M.E., Kanner, W., Harrison, D.G., Dudley, S.C. Mol. Pharmacol. (2003)
- Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1. Gratton, J.P., Fontana, J., O'Connor, D.S., Garcia-Cardena, G., McCabe, T.J., Sessa, W.C. J. Biol. Chem. (2000)
- VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors. Igarashi, J., Erwin, P.A., Dantas, A.P., Chen, H., Michel, T. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Lamas, S., Marsden, P.A., Li, G.K., Tempst, P., Michel, T. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Role of the interdomain linker probed by kinetics of CO ligation to an endothelial nitric oxide synthase mutant lacking the calmodulin binding peptide (residues 503-517 in bovine). Zemojtel, T., Scheele, J.S., Martásek, P., Masters, B.S., Sharma, V.S., Magde, D. Biochemistry (2003)
- Receptor-regulated dynamic interaction between endothelial nitric oxide synthase and calmodulin revealed by fluorescence resonance energy transfer in living cells. Jobin, C.M., Chen, H., Lin, A.J., Yacono, P.W., Igarashi, J., Michel, T., Golan, D.E. Biochemistry (2003)