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Gene Review

DEXI  -  Dexi homolog (mouse)

Homo sapiens

Synonyms: Dexamethasone-induced protein, MYLE, Protein MYLE
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Disease relevance of DEXI


Psychiatry related information on DEXI

  • Dexamethasone-induced increases in the plasma MHPG level were directly correlated with the severity of depressive symptoms and with postdexamethasone cortisol levels in the depressed patients [6].
  • The experiments reported here tested the hypothesis that pre-treatment with oestrogen would also attenuate dexamethasone-induced neuronal damage as oestrogens have neuroprotective actions against a variety of insults and falling levels of oestrogen are associated with increased vulnerability to mood disorders [7].

High impact information on DEXI


Chemical compound and disease context of DEXI


Biological context of DEXI


Anatomical context of DEXI


Associations of DEXI with chemical compounds


Physical interactions of DEXI


Regulatory relationships of DEXI


Other interactions of DEXI


Analytical, diagnostic and therapeutic context of DEXI


  1. Cloning of dexamethasone-induced transcript: a novel glucocorticoid-induced gene that is upregulated in emphysema. Edgar, A.J., Birks, E.J., Yacoub, M.H., Polak, J.M. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  2. PC cell-derived growth factor confers resistance to dexamethasone and promotes tumorigenesis in human multiple myeloma. Wang, W., Hayashi, J., Serrero, G. Clin. Cancer Res. (2006) [Pubmed]
  3. Dexamethasone-induced adhesion in hepatoma cells: the role of plasminogen activator. Fredin, B.L., Seifert, S.C., Gelehrter, T.D. Nature (1979) [Pubmed]
  4. Therapeutic concentrations of glucocorticoids suppress the antimicrobial activity of human macrophages without impairing their responsiveness to gamma interferon. Schaffner, A. J. Clin. Invest. (1985) [Pubmed]
  5. Dexamethasone-induced bradycardia. Ohlsson, A., Heyman, E. Lancet (1988) [Pubmed]
  6. The effects of dexamethasone on plasma homovanillic acid and 3-methoxy-4-hydroxyphenylglycol. Evidence for abnormal corticosteroid-catecholamine interactions in major depression. Wolkowitz, O.M., Doran, A.R., Breier, A., Roy, A., Jimerson, D.C., Sutton, M.E., Golden, R.N., Paul, S.M., Pickar, D. Arch. Gen. Psychiatry (1987) [Pubmed]
  7. 17 Beta-oestradiol attenuates dexamethasone-induced lethal and sublethal neuronal damage in the striatum and hippocampus. Haynes, L.E., Lendon, C.L., Barber, D.J., Mitchell, I.J. Neuroscience (2003) [Pubmed]
  8. Regulation of fibronectin biosynthesis by glucocorticoids in human fibrosarcoma cells and normal fibroblasts. Oliver, N., Newby, R.F., Furcht, L.T., Bourgeois, S. Cell (1983) [Pubmed]
  9. Human clusterin gene expression is confined to surviving cells during in vitro programmed cell death. French, L.E., Wohlwend, A., Sappino, A.P., Tschopp, J., Schifferli, J.A. J. Clin. Invest. (1994) [Pubmed]
  10. Glucocorticoid regulation of insulin receptor gene transcription in IM-9 cultured lymphocytes. McDonald, A.R., Goldfine, I.D. J. Clin. Invest. (1988) [Pubmed]
  11. Primary cortisol resistance associated with a thermolabile glucocorticoid receptor in a patient with fatigue as the only symptom. Brönnegård, M., Werner, S., Gustafsson, J.A. J. Clin. Invest. (1986) [Pubmed]
  12. Dexamethasone-responsive hypertension in young women with suppressed renin and aldosterone. Hoefnagels, W.H., Drayer, J.I., Hofman, J.A., Kloppenborg, P.W., Smals, A.G., Benraad, T.J. Lancet (1978) [Pubmed]
  13. A novel carbohydrate-based therapeutic GCS-100 overcomes bortezomib resistance and enhances dexamethasone-induced apoptosis in multiple myeloma cells. Chauhan, D., Li, G., Podar, K., Hideshima, T., Neri, P., He, D., Mitsiades, N., Richardson, P., Chang, Y., Schindler, J., Carver, B., Anderson, K.C. Cancer Res. (2005) [Pubmed]
  14. 2-(8-Hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propionic acid, a small molecule isocoumarin, potentiates dexamethasone-induced apoptosis of human multiple myeloma cells. Agata, N., Nogi, H., Milhollen, M., Kharbanda, S., Kufe, D. Cancer Res. (2004) [Pubmed]
  15. Enforced expression of superoxide dismutase 2/manganese superoxide dismutase disrupts autocrine interleukin-6 stimulation in human multiple myeloma cells and enhances dexamethasone-induced apoptosis. Hodge, D.R., Xiao, W., Peng, B., Cherry, J.C., Munroe, D.J., Farrar, W.L. Cancer Res. (2005) [Pubmed]
  16. FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance. Yasui, H., Hideshima, T., Raje, N., Roccaro, A.M., Shiraishi, N., Kumar, S., Hamasaki, M., Ishitsuka, K., Tai, Y.T., Podar, K., Catley, L., Mitsiades, C.S., Richardson, P.G., Albert, R., Brinkmann, V., Chauhan, D., Anderson, K.C. Cancer Res. (2005) [Pubmed]
  17. Decreased antioxidant defence and increased oxidant stress during dexamethasone-induced apoptosis: bcl-2 prevents the loss of antioxidant enzyme activity. Baker, A.F., Briehl, M.M., Dorr, R., Powis, G. Cell Death Differ. (1996) [Pubmed]
  18. Analysis of DEXI/Dexi refines the organization of the mouse 7C and human 15q11-->q13 imprinting clusters. Kelly, M., Edgar, A.J., Wevrick, R. Cytogenet. Cell Genet. (2001) [Pubmed]
  19. Roles of p38 and ERK MAP kinases in IL-8 expression in TNF-alpha- and dexamethasone-stimulated human periodontal ligament cells. Lee, H.J., Cho, J.W., Kim, S.C., Kang, K.H., Lee, S.K., Pi, S.H., Lee, S.K., Kim, E.C. Cytokine (2006) [Pubmed]
  20. Ras (proto)oncogene induces N-linked carbohydrate modification: temporal relationship with induction of invasive potential. Bolscher, J.G., van der Bijl, M.M., Neefjes, J.J., Hall, A., Smets, L.A., Ploegh, H.L. EMBO J. (1988) [Pubmed]
  21. Lipocortin 1 mediates dexamethasone-induced growth arrest of the A549 lung adenocarcinoma cell line. Croxtall, J.D., Flower, R.J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  22. Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB. Ayroldi, E., Migliorati, G., Bruscoli, S., Marchetti, C., Zollo, O., Cannarile, L., D'Adamio, F., Riccardi, C. Blood (2001) [Pubmed]
  23. Synergy between dexamethasone and interleukin-5 for the induction of major histocompatibility complex class II expression by human peripheral blood eosinophils. Guida, L., O'Hehir, R.E., Hawrylowicz, C.M. Blood (1994) [Pubmed]
  24. Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma. Hideshima, T., Chauhan, D., Hayashi, T., Podar, K., Akiyama, M., Mitsiades, C., MItsiades, N., Gong, B., Bonham, L., de Vries, P., Munshi, N., Richardson, P.G., Singer, J.W., Anderson, K.C. Cancer Res. (2003) [Pubmed]
  25. Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers. Brunet, C.L., Gunby, R.H., Benson, R.S., Hickman, J.A., Watson, A.J., Brady, G. Cell Death Differ. (1998) [Pubmed]
  26. Glucocorticoid-resistant human acute lymphoblastic leukemic cell line with functional receptor. Zawydiwski, R., Harmon, J.M., Thompson, E.B. Cancer Res. (1983) [Pubmed]
  27. Inhibition of apoptosis by the actin-regulatory protein gelsolin. Ohtsu, M., Sakai, N., Fujita, H., Kashiwagi, M., Gasa, S., Shimizu, S., Eguchi, Y., Tsujimoto, Y., Sakiyama, Y., Kobayashi, K., Kuzumaki, N. EMBO J. (1997) [Pubmed]
  28. Regulation of beta-adrenergic receptors by "permissive" hormones: glucocorticoids increase steady-state levels of receptor mRNA. Hadcock, J.R., Malbon, C.C. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  29. Heterogeneity of the in vitro responses to glucocorticoids in acute leukemia. Homo, F., Duval, D., Harousseau, J.L., Marie, J.P., Zittoun, R. Cancer Res. (1980) [Pubmed]
  30. Repression of glucocorticoid receptor transactivation and DNA binding of a glucocorticoid response element within the serum/glucocorticoid-inducible protein kinase (sgk) gene promoter by the p53 tumor suppressor protein. Maiyar, A.C., Phu, P.T., Huang, A.J., Firestone, G.L. Mol. Endocrinol. (1997) [Pubmed]
  31. Metabolite-P450 complex formation by methylenedioxyphenyl HIV protease inhibitors in rat and human liver microsomes. Chiba, M., Nishime, J.A., Chen, I.W., Vastag, K.J., Sahly, Y.S., Kim, B.M., Dorsey, B.D., Vacca, J.P., Lin, J.H. Biochem. Pharmacol. (1998) [Pubmed]
  32. Induction of fibronectin matrix assembly in human fibrosarcoma cells by dexamethasone. McKeown-Longo, P.J., Etzler, C.A. J. Cell Biol. (1987) [Pubmed]
  33. Identification of transformed glucocorticoid receptor from dexamethasone resistant melanoma. Hutchens, T.W., Hawkins, E.F., Markland, F.S. J. Steroid Biochem. (1982) [Pubmed]
  34. Antioxidants inhibit human endothelial cell functions through down-regulation of endothelial nitric oxide synthase activity. Polytarchou, C., Papadimitriou, E. Eur. J. Pharmacol. (2005) [Pubmed]
  35. Thioredoxin-interacting protein (txnip) is a glucocorticoid-regulated primary response gene involved in mediating glucocorticoid-induced apoptosis. Wang, Z., Rong, Y.P., Malone, M.H., Davis, M.C., Zhong, F., Distelhorst, C.W. Oncogene (2006) [Pubmed]
  36. TGF-beta regulation of human macrophage scavenger receptor CD163 is Smad3-dependent. Pioli, P.A., Goonan, K.E., Wardwell, K., Guyre, P.M. J. Leukoc. Biol. (2004) [Pubmed]
  37. Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Croxtall, J.D., Choudhury, Q., Flower, R.J. Br. J. Pharmacol. (2000) [Pubmed]
  38. Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK. Swantek, J.L., Cobb, M.H., Geppert, T.D. Mol. Cell. Biol. (1997) [Pubmed]
  39. Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression. Urban, G., Golden, T., Aragon, I.V., Cowsert, L., Cooper, S.R., Dean, N.M., Honkanen, R.E. J. Biol. Chem. (2003) [Pubmed]
  40. Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation. Dvorak, Z., Modriansky, M., Pichard-Garcia, L., Balaguer, P., Vilarem, M.J., Ulrichová, J., Maurel, P., Pascussi, J.M. Mol. Pharmacol. (2003) [Pubmed]
  41. Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors. Jego, G., Bataille, R., Geffroy-Luseau, A., Descamps, G., Pellat-Deceunynck, C. Leukemia (2006) [Pubmed]
  42. Novel therapies targeting the myeloma cell and its bone marrow microenvironment. Hideshima, T., Chauhan, D., Podar, K., Schlossman, R.L., Richardson, P., Anderson, K.C. Semin. Oncol. (2001) [Pubmed]
  43. Oncostatin M down-regulates basal and induced cytochromes P450 in human hepatocytes. Guillén, M.I., Donato, M.T., Jover, R., Castell, J.V., Fabra, R., Trullenque, R., Gómez-Lechón, M.J. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  44. Acute effects of dexamethasone on cation transport in colonic epithelium. Sandle, G.I., McGlone, F. Gut (1987) [Pubmed]
  45. Effect of dexamethasone on insulin sensitivity, islet amyloid polypeptide and insulin secretion in humans. Ludvik, B., Clodi, M., Kautzky-Willer, A., Capek, M., Hartter, E., Pacini, G., Prager, R. Diabetologia (1993) [Pubmed]
  46. Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women. Larsson, H., Ahrén, B. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  47. The phenotypic plasticity of myeloma plasma cells as expressed by dedifferentiation into an immature, resilient, and apoptosis-resistant phenotype. Yaccoby, S. Clin. Cancer Res. (2005) [Pubmed]
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