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NDUFAF4  -  NADH dehydrogenase (ubiquinone) complex I,...

Homo sapiens

Synonyms: C6orf66, HRPAP20, HSPC125, Hormone-regulated proliferation-associated protein of 20 kDa, My013, ...
 
 
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Disease relevance of C6orf66

  • Using 5'-rapid amplification of complementary ends-PCR, this fragment was used to clone a unique 2117-bp cDNA, designated HRPAP20 (hormone-regulated proliferation-associated protein), in rat lymphoma cells [1].
  • Transfection of MCF-7 breast cancer cells with HRPAP20 harboring a mutated CaM-binding motif (HRPAP20K73A) inhibited its interaction with CaM and failed to increase invasion [2].
 

High impact information on C6orf66

  • Exposure of the cells to butyrate or retinoic acid reduced HRPAP20 expression, similar to the effects of these substances in the malignant rat lymphoma [1].
  • Stable transfection of HRPAP20 into MCF-7 cells significantly (P < 0.006) increased proliferation in the absence of hormone stimulation and augmented survival in the absence of serum (P < 0.05) [1].
  • Quiescent cells, synchronized in the G(0)-G(1) phase of cell cycle, exhibited reduced HRPAP20 expression compared with exponentially proliferating cultures [1].
  • Stable transfection of the HRPAP20 cDNA into Nb2-11 cells significantly (P < 0.01) increased proliferation in the absence of hormonal stimulation and inhibited apoptosis induced by lactogen deprivation (P < 0.001) [1].
 

Associations of C6orf66 with chemical compounds

  • In the hormone-independent and highly malignant Nb2-SFJCD1 subline, the constitutive expression of HRPAP20 was markedly reduced by exposure of the cells to dietary differentiating agents (butyrate, retinoic acid, and vitamin D(3)) [1].

References

  1. Identification of HRPAP20: a novel phosphoprotein that enhances growth and survival in hormone-responsive tumor cells. Karp, C.M., Pan, H., Zhang, M., Buckley, D.J., Schuler, L.A., Buckley, A.R. Cancer Res. (2004) [Pubmed]
  2. HRPAP20: a novel calmodulin-binding protein that increases breast cancer cell invasion. Karp, C.M., Shukla, M.N., Buckley, D.J., Buckley, A.R. Oncogene (2007) [Pubmed]
 
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