Gene Review:
Ucn - urocortin
Rattus norvegicus
Synonyms:
Corticotensin, Urocortin
Kozicz,
Arimura,
Torpy,
Webster,
Zachman,
Aguilera,
Chrousos,
Zorrilla,
Schulteis,
Ormsby,
Klaassen,
Ling,
McCarthy,
Koob,
De Souza,
Nazarloo,
Nishiyama,
Tanaka,
Asaba,
Hashimoto,
Benoit,
Thiele,
Heinrichs,
Rushing,
Blake,
Steeley,
Terui,
Higashiyama,
Horiba,
Furukawa,
Motomura,
Suda,
Kozicz,
Grill,
Markison,
Ginsberg,
Kaplan,
Rainnie,
Bergeron,
Sajdyk,
Patil,
Gehlert,
Shekhar,
Gehlert,
Shekhar,
Morin,
Hipskind,
Zink,
Gackenheimer,
Shaw,
Fitz,
Sajdyk,
Kageyama,
Suda,
Sajdyk,
Fitz,
Shekhar,
Kozicz,
Yanaihara,
Arimura,
Parkes,
Vaughan,
Rivier,
Vale,
May,
Kageyama,
Hanada,
Nigawara,
Moriyama,
Terui,
Sakihara,
Suda,
Spina,
Langnaese,
Orlando,
Horn,
Rivier,
Vale,
Wolf,
Engelmann,
- Cardiotrophin-1 and urocortin cause protection by the same pathway and hypertrophy via distinct pathways in cardiac myocytes. Railson, J.E., Liao, Z., Brar, B.K., Buddle, J.C., Pennica, D., Stephanou, A., Latchman, D.S. Cytokine (2002)
- Urocortin and inflammation: confounding effects of hypotension on measures of inflammation. Torpy, D.J., Webster, E.L., Zachman, E.K., Aguilera, G., Chrousos, G.P. Neuroimmunomodulation (1999)
- Urocortin has cell-proliferative effects on cardiac non-myocytes. Ikeda, K., Tojo, K., Oki, Y., Nakao, K. Life Sci. (2002)
- Stress and autoimmunity: the neuropeptides corticotropin-releasing factor and urocortin suppress encephalomyelitis via effects on both the hypothalamic-pituitary-adrenal axis and the immune system. Poliak, S., Mor, F., Conlon, P., Wong, T., Ling, N., Rivier, J., Vale, W., Steinman, L. J. Immunol. (1997)
- The role of neuropeptide Y in the amygdala on corticotropin-releasing factor receptor-mediated behavioral stress responses in the rat. Sajdyk, T.J., Fitz, S.D., Shekhar, A. Stress (Amsterdam, Netherlands) (2006)
- The postnatal developmental expression pattern of urocortin in the rat olivocerebellar system. Swinny, J.D., Kalicharan, D., Brouwer, N., Biber, K., Shi, F., Gramsbergen, A., van der Want, J.J. J. Comp. Neurol. (2004)
- Down-regulation of corticotropin-releasing hormone receptor type 2beta mRNA expression in the rat cardiovascular system following food deprivation. Nazarloo, H.P., Nishiyama, M., Tanaka, Y., Asaba, K., Hashimoto, K. Regul. Pept. (2002)
- Neurons colocalizing urocortin and cocaine and amphetamine-regulated transcript immunoreactivities are induced by acute lipopolysaccharide stress in the Edinger-Westphal nucleus in the rat. Kozicz, T. Neuroscience (2003)
- Stress and central Urocortin increase anxiety-like behavior in the social interaction test via the CRF1 receptor. Gehlert, D.R., Shekhar, A., Morin, S.M., Hipskind, P.A., Zink, C., Gackenheimer, S.L., Shaw, J., Fitz, S.D., Sajdyk, T.J. Eur. J. Pharmacol. (2005)
- Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Vaughan, J., Donaldson, C., Bittencourt, J., Perrin, M.H., Lewis, K., Sutton, S., Chan, R., Turnbull, A.V., Lovejoy, D., Rivier, C. Nature (1995)
- Mechanisms of sympathoadrenal failure and hypoglycemia in diabetes. Cryer, P.E. J. Clin. Invest. (2006)
- Role of peripheral corticotropin-releasing factor and urocortin II in intestinal inflammation and motility in terminal ileum. la Fleur, S.E., Wick, E.C., Idumalla, P.S., Grady, E.F., Bhargava, A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway. Brar, B.K., Jonassen, A.K., Stephanou, A., Santilli, G., Railson, J., Knight, R.A., Yellon, D.M., Latchman, D.S. J. Biol. Chem. (2000)
- Cardioprotective action of CRF peptide urocortin against simulated ischemia in adult rat cardiomyocytes. Gordon, J.M., Dusting, G.J., Woodman, O.L., Ritchie, R.H. Am. J. Physiol. Heart Circ. Physiol. (2003)
- Urocortinergic neurons respond in a differentiated manner to various acute stressors in the Edinger-Westphal nucleus in the rat. Gaszner, B., Csernus, V., Kozicz, T. J. Comp. Neurol. (2004)
- Long-term effects on feeding and body weight after stimulation of forebrain or hindbrain CRH receptors with urocortin. Grill, H.J., Markison, S., Ginsberg, A., Kaplan, J.M. Brain Res. (2000)
- Urocortin induces interleukin-6 gene expression via cyclooxygenase-2 activity in aortic smooth muscle cells. Kageyama, K., Hanada, K., Nigawara, T., Moriyama, T., Terui, K., Sakihara, S., Suda, T. Endocrinology (2006)
- Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats. Czimmer, J., Million, M., Taché, Y. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- Comparison of central administration of corticotropin-releasing hormone and urocortin on food intake, conditioned taste aversion, and c-Fos expression. Benoit, S.C., Thiele, T.E., Heinrichs, S.C., Rushing, P.A., Blake, K.A., Steeley, R.J. Peptides (2000)
- Coronary vasodilation and positive inotropism by urocortin in the isolated rat heart. Terui, K., Higashiyama, A., Horiba, N., Furukawa, K.I., Motomura, S., Suda, T. J. Endocrinol. (2001)
- Distribution of urocortin-like immunoreactivity in the central nervous system of the rat. Kozicz, T., Yanaihara, H., Arimura, A. J. Comp. Neurol. (1998)
- Colocalization of urocortin and neuronal nitric oxide synthase in the hypothalamus and Edinger-Westphal nucleus of the rat. Spina, M.G., Langnaese, K., Orlando, G.F., Horn, T.F., Rivier, J., Vale, W.W., Wolf, G., Engelmann, M. J. Comp. Neurol. (2004)
- Urocortin-related peptides increase interleukin-6 output via cyclic adenosine 5'-monophosphate-dependent pathways in A7r5 aortic smooth muscle cells. Kageyama, K., Suda, T. Endocrinology (2003)
- Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors. Zorrilla, E.P., Schulteis, G., Ormsby, A., Klaassen, A., Ling, N., McCarthy, J.R., Koob, G.F., De Souza, E.B. Brain Res. (2002)
- Chronic cocaine administration switches corticotropin-releasing factor2 receptor-mediated depression to facilitation of glutamatergic transmission in the lateral septum. Liu, J., Yu, B., Orozco-Cabal, L., Grigoriadis, D.E., Rivier, J., Vale, W.W., Shinnick-Gallagher, P., Gallagher, J.P. J. Neurosci. (2005)
- The first extracellular domain of corticotropin releasing factor-R1 contains major binding determinants for urocortin and astressin. Perrin, M.H., Sutton, S., Bain, D.L., Berggren, W.T., Vale, W.W. Endocrinology (1998)
- CRH-like peptides protect cardiac myocytes from lethal ischaemic injury. Brar, B.K., Stephanou, A., Okosi, A., Lawrence, K.M., Knight, R.A., Marber, M.S., Latchman, D.S. Mol. Cell. Endocrinol. (1999)
- Characterization of the relaxant action of urocortin, a new peptide related to corticotropin-releasing factor in the rat isolated basilar artery. Schilling, L., Kanzler, C., Schmiedek, P., Ehrenreich, H. Br. J. Pharmacol. (1998)
- Expression of corticotropin releasing factor (CRF), urocortin and CRF type 1 receptors in hypothalamic-hypophyseal systems under osmotic stimulation. Imaki, T., Katsumata, H., Miyata, M., Naruse, M., Imaki, J., Minami, S. J. Neuroendocrinol. (2001)
- Corticotrophin releasing factor-induced synaptic plasticity in the amygdala translates stress into emotional disorders. Rainnie, D.G., Bergeron, R., Sajdyk, T.J., Patil, M., Gehlert, D.R., Shekhar, A. J. Neurosci. (2004)
- Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I. Pedersen, W.A., Wan, R., Zhang, P., Mattson, M.P. J. Neurosci. (2002)
- Distribution of urocortin in the rat's gastrointestinal tract and its colocalization with tyrosine hydroxylase. Kozicz, T., Arimura, A. Peptides (2002)
- Acute stress results in skin corticotropin-releasing hormone secretion, mast cell activation and vascular permeability, an effect mimicked by intradermal corticotropin-releasing hormone and inhibited by histamine-1 receptor antagonists. Lytinas, M., Kempuraj, D., Huang, M., Boucher, W., Esposito, P., Theoharides, T.C. Int. Arch. Allergy Immunol. (2003)
- Cardiac inotropic actions of urocortin in conscious sheep. Parkes, D.G., Vaughan, J., Rivier, J., Vale, W., May, C.N. Am. J. Physiol. (1997)
- Corticotropin-releasing factor but not urocortin is involved in adrenalectomy-induced adrenocorticotropin release. Masuzawa, M., Oki, Y., Ozawa, M., Watanabe, F., Yoshimi, T. J. Neuroendocrinol. (1999)