Gene Review:
Psen1 - presenilin 1
Rattus norvegicus
Synonyms:
PS-1, Presenilin-1, Protein S182, Psnl1
- Hypoxic remodelling of Ca2+ mobilization in type I cortical astrocytes: involvement of ROS and pro-amyloidogenic APP processing. Smith, I.F., Boyle, J.P., Green, K.N., Pearson, H.A., Peers, C. J. Neurochem. (2004)
- Cloning of the cDNA encoding rat Presenilin-1. Taniguchi, T., Hashimoto, T., Taniguchi, R., Shimada, K., Kawamata, T., Yasuda, M., Nakai, M., Terashima, A., Koizumi, T., Maeda, K., Tanaka, C. Gene (1997)
- The regulation of presenilin-1 by nerve growth factor. Counts, S.E., Lah, J.J., Levey, A.I. J. Neurochem. (2001)
- Localization of presenilin-1 mRNA in rat brain. Quarteronet, D., Pradier, L., Czech, C., Delalonde, L., Burgevin, M.C., Doble, A., Petitet, F. Neuroreport (1996)
- Expression of presenilin 1 mRNA in rat peripheral organs and brain. Nilsberth, C., Luthman, J., Lannfelt, L., Schultzberg, M. Histochem. J. (1999)
- Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria. Hansson, C.A., Frykman, S., Farmery, M.R., Tjernberg, L.O., Nilsberth, C., Pursglove, S.E., Ito, A., Winblad, B., Cowburn, R.F., Thyberg, J., Ankarcrona, M. J. Biol. Chem. (2004)
- A detergent-insoluble membrane compartment contains A beta in vivo. Lee, S.J., Liyanage, U., Bickel, P.E., Xia, W., Lansbury, P.T., Kosik, K.S. Nat. Med. (1998)
- Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease. Guo, Q., Fu, W., Xie, J., Luo, H., Sells, S.F., Geddes, J.W., Bondada, V., Rangnekar, V.M., Mattson, M.P. Nat. Med. (1998)
- Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Kim, T.W., Pettingell, W.H., Jung, Y.K., Kovacs, D.M., Tanzi, R.E. Science (1997)
- Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation. Teo, J.L., Ma, H., Nguyen, C., Lam, C., Kahn, M. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Mutant presenilin (A260V) affects Rab8 in PC12D cell. Kametani, F., Usami, M., Tanaka, K., Kume, H., Mori, H. Neurochem. Int. (2004)
- Detection of the presenilin 1 COOH-terminal fragment in the extracellular compartment: a release enhanced by apoptosis. Benussi, L., Alberici, A., Mayhaus, M., Langer, U., Ghidoni, R., Mazzoli, F., Nicosia, F., Barbiero, L., Frisoni, G., Zanetti, O., Gasparini, L., Nitsch, R.M., Binetti, G. Exp. Cell Res. (2001)
- Transient abundance of presenilin 1 fragments/nicastrin complex associated with synaptogenesis during development in rat cerebellum. Uchihara, T., Sanjo, N., Nakamura, A., Han, K., Song, S.Y., St George-Hyslop, P., Fraser, P.E. Neurobiol. Aging (2006)
- Presenilin-1 protects against neuronal apoptosis caused by its interacting protein PAG. Zhou, Y., Zhang, W., Easton, R., Ray, J.W., Lampe, P., Jiang, Z., Brunkan, A.L., Goate, A., Johnson, E.M., Wu, J.Y. Neurobiol. Dis. (2002)
- Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis. Guo, Q., Robinson, N., Mattson, M.P. J. Biol. Chem. (1998)
- Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function. Guo, Q., Christakos, S., Robinson, N., Mattson, M.P. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Normal distribution of presenilin-1 and nicastrin in skeletal muscle and the differential responses of these proteins after denervation. Sakuma, K., Nakao, R., Yamasa, Y., Yasuhara, M. Biochim. Biophys. Acta (2006)
- Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production. Keller, J.N., Guo, Q., Holtsberg, F.W., Bruce-Keller, A.J., Mattson, M.P. J. Neurosci. (1998)
- Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide. Guo, Q., Furukawa, K., Sopher, B.L., Pham, D.G., Xie, J., Robinson, N., Martin, G.M., Mattson, M.P. Neuroreport (1996)
- Calcium oscillations in type-1 astrocytes, the effect of a presenilin 1 (PS1) mutation. Johnston, J.M., Burnett, P., Thomas, A.P., Tezapsidis, N. Neurosci. Lett. (2006)
- Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments. Lah, J.J., Levey, A.I. Mol. Cell. Neurosci. (2000)
- Presenilin-1 mRNA and beta-amyloid precursor protein mRNA are expressed in the developing rat olfactory and vestibulocochlear systems. Utsumi, M., Sato, K., Tanimukai, H., Kudo, T., Nishimura, M., Takeda, M., Tohyama, M. Acta Otolaryngol. (1998)
- A novel mechanism for the regulation of amyloid precursor protein metabolism. Chen, Q., Kimura, H., Schubert, D. J. Cell Biol. (2002)
- Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain. Beher, D., Elle, C., Underwood, J., Davis, J.B., Ward, R., Karran, E., Masters, C.L., Beyreuther, K., Multhaup, G. J. Neurochem. (1999)
- Expressions of amyloid precursor protein, synaptophysin and presenilin-1 in the different areas of the developing cerebellum of rat. Fakla, I., Kovacs, I., Yamaguchi, H., Geula, C., Kasa, P. Neurochem. Int. (2000)
- Presenilin-1 is located in rat mitochondria. Ankarcrona, M., Hultenby, K. Biochem. Biophys. Res. Commun. (2002)
- In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain. Page, K., Hollister, R., Tanzi, R.E., Hyman, B.T. Proc. Natl. Acad. Sci. U.S.A. (1996)