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Gene Review

SLC25A5  -  solute carrier family 25 (mitochondrial...

Homo sapiens

Synonyms: 2F1, AAC2, ADP,ATP carrier protein 2, ADP,ATP carrier protein, fibroblast isoform, ADP/ATP translocase 2, ...
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Disease relevance of SLC25A5

  • The ANT2 silencer region cloned in front of the herpes simplex virus thymidine kinase promoter confers nearly complete inhibition to the heterologous promoter [1].
  • One of the putative genes is homologous to a gene implicated in Graves' disease and it, ANT2 and two others are confirmed by EST matches [2].
  • Most importantly, ANT2, but not ANT1, silencing facilitated MMP induction by lonidamine, a mitochondrion-targeted antitumor compound already used in clinical studies for breast, ovarian, glioma, and lung cancer as well as prostate adenoma [3].
  • Defects in both T1, the translocase specific for glucose-6-P, and T2 thus appear involved in this unique glycogenosis [4].
  • All melanomas were clearly observed on both T1- and T2-weighted images (T1WI and T2WI), with viable tumor regions generally characterized by low to intermediate intensity on T1WI and high intensity on T2WI [5].

Psychiatry related information on SLC25A5


High impact information on SLC25A5

  • Interestingly, a homologue of ANT3, ANT2, maps to Xq and is subject to X-inactivation [11].
  • Microsomes prepared from Raji and T1 cells show similar levels of assembly, whereas assembly in T2 microsomes is 10-fold lower [12].
  • T3 gene expression is therefore a very early event in T cell differentiation [13].
  • Equivalent normal T cells isolated from thymus have a predominantly germ-line configuration of TCR beta but contain intracellular T3 proteins [13].
  • Mutant cells RMA-S and .174/T2 neither assemble stable class I molecules nor present intracellular antigens, and we have suggested that they have lost a function required for the transport of short peptides from the cytosol to the endoplasmic reticulum [14].

Chemical compound and disease context of SLC25A5

  • The fourth, with hepatomegaly and no hypoglycaemic symptoms, had a normal glucose-6-phosphatase enzyme but a defect in the hepatic microsomal phosphate/pyrophosphate translocase T2; this is the first report of an adult with type 1c GSD [15].
  • INTRODUCTION: Marked changes in peripheral thyroid hormone metabolism occur in critical illness, resulting in low serum T3 and high rT3 levels [16].
  • The familial effect on gender-adjusted 24-h EE was explained mainly by a familial resemblance of fat-free mass (ri = 0.48; P < 0.015) and fat mass (ri = 0.40; P < 0.03), whereas spontaneous physical activity and plasma concentrations of T2 and norepinephrine did not correlate in families [17].
  • An additional 10% of the total variation was explained by differences in spontaneous physical activity (P < 0.00001), fat mass (P < 0.00001), plasma concentration of free T3 (P < 0.003), and norepinephrine (P < 0.002), whereas plasma values of epinephrine and androgen hormones did not correlate with 24-h EE [17].
  • Sequence specificity of the wild-type dam+) and mutant (damh) forms of bacteriophage T2 DNA adenine methylase [18].

Biological context of SLC25A5


Anatomical context of SLC25A5

  • Expression of human ANT2 gene in highly proliferative cells: GRBOX, a new transcriptional element, is involved in the regulation of glycolytic ATP import into mitochondria [20].
  • The level of ANT2 expression and glycolytic ATP production in these cell lines were in keeping with their metabolic background and their state of differentiation [21].
  • The levels of T2 and T3 mRNAs in HeLa cells are differentially affected by the growth conditions [22].
  • In particular, the two T2-specific mRNAs are present at high, similar levels in myoblasts and myotubes and markedly decrease in amount in mature adult muscle [23].
  • Treatment of HL60 cells with 12-O-tetradecanoylphorbol-13-acetate or retinoic acid, two agents which induce cessation of cell proliferation and cell differentiation, resulted in a marked decrease in both T2 and T3 mRNA levels [22].

Associations of SLC25A5 with chemical compounds

  • The combination of ANT2 knockdown with lonidamine induced apoptosis irrespective of the Bcl-2 status [3].
  • T2-weighted images of the thigh muscles showed inflammation even when serum creatine phosphokinase levels were in the normal range [24].
  • Exposure of HeLa cells to chloramphenicol produced a pronounced decrease in the levels of both T2 and T3 mRNAs after 48 to 72 h of treatment [22].
  • Treatment of HeLa cells with dinitrophenol also produced a dramatic decrease in the steady state levels of both T2 and T3 mRNA, which, however, in contrast to the just mentioned situation, could be accounted for by a decrease in their metabolic stability [22].
  • T2 T2 measurements suggested that intrinsic line widths of most cytosine C2 peaks were 4 Hz and 2-3 Hz for uracil [25].

Physical interactions of SLC25A5

  • NF1 binding correlated with the disappearance of ANT2 transcripts in quiescent cells [19].
  • DFT3 depended on the level of T4 in serum more than T3 concentration and was in inverse relationship with the maximal binding capacity of TBG [26].

Regulatory relationships of SLC25A5

  • For CP Ti, VHN means of T2 group was remarkably higher than those of control and T1 group, which showed similar VHN means to each other [27].

Other interactions of SLC25A5

  • METHODS: Data were obtained from the Massachusetts Male Aging Study, a population-based prospective cohort of 1709 men observed at three time points (T1, 1987-1989; T2, 1995-1997; T3, 2002-2004) [28].
  • Thus, enhanced binding of NF1 is a key step in the growth arrest repression of ANT2 transcription [19].
  • We propose a new model for ATP uptake in cancer cells implicating the ANT2 isoform, in conjunction with hexokinase II and the beta subunit of mitochondrial ATP synthase, in the Deltapsi maintenance and in the aggressiveness of cancer cells [21].
  • An inverse linear correlation was found between TBG-DFT4 (alpha = 0.05) and DF T 3 (alpha = 0.002), TBPA-log DF T4 (alpha = 0.05) but not between TBG and TBPA [26].
  • This suggests that (i) a pathway for egress of Pi from the microsomal lumen exists independently of T2, (ii) T2 in this case works only unidirectionally, or (iii) the catalytic unit of glucose 6-phosphatase in situ has become desensitized to interactions with Pi, PPi, and carbamyl-P in this mutant model [4].

Analytical, diagnostic and therapeutic context of SLC25A5


  1. Characterization of a silencer element and purification of a silencer protein that negatively regulates the human adenine nucleotide translocator 2 promoter. Baráth, P., Albert-Fournier, B., Luciaková, K., Nelson, B.D. J. Biol. Chem. (1999) [Pubmed]
  2. Ordered shotgun sequencing of a 135 kb Xq25 YAC containing ANT2 and four possible genes, including three confirmed by EST matches. Chen, C.N., Su, Y., Baybayan, P., Siruno, A., Nagaraja, R., Mazzarella, R., Schlessinger, D., Chen, E. Nucleic Acids Res. (1996) [Pubmed]
  3. Chemosensitization by knockdown of adenine nucleotide translocase-2. Le Bras, M., Borgne-Sanchez, A., Touat, Z., El Dein, O.S., Deniaud, A., Maillier, E., Lecellier, G., Rebouillat, D., Lemaire, C., Kroemer, G., Jacotot, E., Brenner, C. Cancer Res. (2006) [Pubmed]
  4. Type Ic, a novel glycogenosis. Underlying mechanism. Nordlie, R.C., Sukalski, K.A., Muñoz, J.M., Baldwin, J.J. J. Biol. Chem. (1983) [Pubmed]
  5. Magnetic resonance imaging of implanted melanomas before and after chemotherapy. Relation to 31P magnetic resonance spectroscopy and tumor histology. Iyer, S.B., Goldberg, H.I., Benz, C.C. Investigative radiology. (1990) [Pubmed]
  6. Cultural affiliation and self-esteem as predictors of internalizing symptoms among mexican american adolescents. McDonald, E.J., McCabe, K., Yeh, M., Lau, A., Garland, A., Hough, R.L. Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53. (2005) [Pubmed]
  7. Residual outcome expectations and relapse in ex-smokers. Dijkstra, A., Borland, R. Health psychology : official journal of the Division of Health Psychology, American Psychological Association. (2003) [Pubmed]
  8. A prospective study of youth gambling behaviors. Winters, K.C., Stinchfield, R.D., Botzet, A., Anderson, N. Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors. (2002) [Pubmed]
  9. Effects of work overload and burnout on cholesterol and triglycerides levels: the moderating effects of emotional reactivity among male and female employees. Shirom, A., Westman, M., Shamai, O., Carel, R.S. Journal of occupational health psychology. (1997) [Pubmed]
  10. Mental development and learning disorders in children with single suture craniosynostosis. Kapp-Simon, K.A. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. (1998) [Pubmed]
  11. A human pseudoautosomal gene, ADP/ATP translocase, escapes X-inactivation whereas a homologue on Xq is subject to X-inactivation. Schiebel, K., Weiss, B., Wöhrle, D., Rappold, G. Nat. Genet. (1993) [Pubmed]
  12. ATP is required for in vitro assembly of MHC class I antigens but not for transfer of peptides across the ER membrane. Lévy, F., Gabathuler, R., Larsson, R., Kvist, S. Cell (1991) [Pubmed]
  13. Developmentally regulated rearrangement and expression of genes encoding the T cell receptor-T3 complex. Furley, A.J., Mizutani, S., Weilbaecher, K., Dhaliwal, H.S., Ford, A.M., Chan, L.C., Molgaard, H.V., Toyonaga, B., Mak, T., van den Elsen, P. Cell (1986) [Pubmed]
  14. Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex. Kelly, A., Powis, S.H., Kerr, L.A., Mockridge, I., Elliott, T., Bastin, J., Uchanska-Ziegler, B., Ziegler, A., Trowsdale, J., Townsend, A. Nature (1992) [Pubmed]
  15. Diagnosis of type 1a and type 1c glycogen storage diseases in adults. Burchell, A., Jung, R.T., Lang, C.C., Bennet, W., Shepherd, A.N. Lancet (1987) [Pubmed]
  16. Increased thyroxine sulfate levels in critically ill patients as a result of a decreased hepatic type I deiodinase activity. Peeters, R.P., Kester, M.H., Wouters, P.J., Kaptein, E., van Toor, H., Visser, T.J., Van den Berghe, G. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  17. Twenty-four-hour energy expenditure: the role of body composition, thyroid status, sympathetic activity, and family membership. Toubro, S., Sørensen, T.I., Rønn, B., Christensen, N.J., Astrup, A. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  18. Sequence specificity of the wild-type dam+) and mutant (damh) forms of bacteriophage T2 DNA adenine methylase. Hattman, S., van Ormondt, H., de Waard, A. J. Mol. Biol. (1978) [Pubmed]
  19. Repression of the human adenine nucleotide translocase-2 gene in growth-arrested human diploid cells: the role of nuclear factor-1. Luciakova, K., Barath, P., Poliakova, D., Persson, A., Nelson, B.D. J. Biol. Chem. (2003) [Pubmed]
  20. Expression of human ANT2 gene in highly proliferative cells: GRBOX, a new transcriptional element, is involved in the regulation of glycolytic ATP import into mitochondria. Giraud, S., Bonod-Bidaud, C., Wesolowski-Louvel, M., Stepien, G. J. Mol. Biol. (1998) [Pubmed]
  21. ANT2 isoform required for cancer cell glycolysis. Chevrollier, A., Loiseau, D., Chabi, B., Renier, G., Douay, O., Malthièry, Y., Stepien, G. J. Bioenerg. Biomembr. (2005) [Pubmed]
  22. Differential regulation of expression of the multiple ADP/ATP translocase genes in human cells. Lunardi, J., Attardi, G. J. Biol. Chem. (1991) [Pubmed]
  23. The multiple ADP/ATP translocase genes are differentially expressed during human muscle development. Lunardi, J., Hurko, O., Engel, W.K., Attardi, G. J. Biol. Chem. (1992) [Pubmed]
  24. Magnetic resonance imaging and P-31 magnetic resonance spectroscopy provide unique quantitative data useful in the longitudinal management of patients with dermatomyositis. Park, J.H., Vital, T.L., Ryder, N.M., Hernanz-Schulman, M., Partain, C.L., Price, R.R., Olsen, N.J. Arthritis Rheum. (1994) [Pubmed]
  25. Transfer RNA structure by carbon NMR: C2 of adenine, uracil and cytosine. Schmidt, P.G., Tompson, J.G., Agris, P.F. Nucleic Acids Res. (1980) [Pubmed]
  26. Short and long term effects of radioiodine and antithyroid drugs on T4 binding proteins, free T4 and T3, during Graves' disease therapy. Jaffiol, C., Baldet, L., Robin, M., Papachristou, C., Lapinski, H., Mirouze, J. Horm. Metab. Res. (1977) [Pubmed]
  27. Vickers hardness of cast commercially pure titanium and Ti-6Al-4V alloy submitted to heat treatments. da Rocha, S.S., Adabo, G.L., Henriques, G.E., Nóbilo, M.A. Brazilian dental journal. (2006) [Pubmed]
  28. Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. Kupelian, V., Page, S.T., Araujo, A.B., Travison, T.G., Bremner, W.J., McKinlay, J.B. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  29. The 3D positioning of ANT2 and ANT3 genes within female X chromosome territories correlates with gene activity. Dietzel, S., Schiebel, K., Little, G., Edelmann, P., Rappold, G.A., Eils, R., Cremer, C., Cremer, T. Exp. Cell Res. (1999) [Pubmed]
  30. The relationship between libido and testosterone levels in aging men. Travison, T.G., Morley, J.E., Araujo, A.B., O'Donnell, A.B., McKinlay, J.B. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  31. In vivo mapping of the human adenine nucleotide translocator-2 (ANT2) promoter provides support for regulation by a pair of proximal Sp1-activating sites and an upstream silencer element. Luciakova, K., Hodny, Z., Barath, P., Nelson, B.D. Biochem. J. (2000) [Pubmed]
  32. Effect of a hypoglycemic agent on ischemic preconditioning in patients with type 2 diabetes and stable angina pectoris. Hueb, W., Uchida, A.H., Gersh, B.J., Betti, R.T., Lopes, N., Moffa, P.J., Ferreira, B.M., Ramires, J.A., Wajchenberg, B.L. Coron. Artery Dis. (2007) [Pubmed]
  33. Psychometric evaluation of two scales assessing functional status and peripheral neuropathy associated with chemotherapy for ovarian cancer: a gynecologic oncology group study. Almadrones, L., McGuire, D.B., Walczak, J.R., Florio, C.M., Tian, C. Oncology nursing forum. (2004) [Pubmed]
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