Disease relevance of Itgb3

• Integrin beta1 is active particularly at sites of inflammation and fibrosis, whereas integrin beta3 localizes to vessels in the peri-infarct zone in a temporally coordinated manner [1].

High impact information on Itgb3

• Latent transforming growth factor-beta binding protein-1, a component of latent transforming growth factor-beta complex, accelerates the migration of aortic smooth muscle cells in diabetic rats through integrin-beta3 [2].
• We have identified a novel integrin beta3 subunit, termed beta3C, from a human osteoclast cDNA library [3].
• These responses were inhibited by F11, a monoclonal antibody to the rat integrin beta 3 chain, as well as echistatin, a snake venom shown to colocalise with the alpha v chain in osteoclasts, suggesting that the calcium signal is mediated by the alpha v beta 3 form of VNR.(ABSTRACT TRUNCATED AT 250 WORDS)[4]
• On the other hand, integrin alphav mRNA level was markedly increased ( approximately twofold), while integrin beta3 mRNA level was decreased ( approximately 50%) at 1 h post-training [5].
• We found that integrin beta3 gene expression was increased by spironolactone, and reversed by aldosterone or dexamethasone in a dose dependent manner [6].

Biological context of Itgb3

• Polyamine depletion by DFMO increased integrin beta3 Tyr785 phosphorylation [7].
• Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3 [7].
• Spironolactone increases integrin beta3 gene expression in kidney and heart muscle cells [6].

Anatomical context of Itgb3

• Integrin beta1A localized primarily in fibroblasts and inflammatory cells, beta1D localized in myocytes, and integrin beta3 was associated primarily with endothelial and smooth muscle cells in peri-infarct vessels [1].
• In summary, spironolactone increases integrin beta3 gene expression in kidney epithelial cells and cardiomyocytes [6].
• YPEN-1 and YPEN-2 cells exhibit positive staining for endothelin and MRC OX-43 and express Integrin a6 beta 1 and Integrin beta 3 on their plasma membrane and demonstrate tube formation in Matrigel [8].

References