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Gene Review

Plcg2  -  phospholipase C, gamma 2

Rattus norvegicus

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, PLC-IV, PLC-gamma-2, Phosphoinositide phospholipase C-gamma-2, Phospholipase C-IV, ...
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Disease relevance of Plcg2


High impact information on Plcg2


Biological context of Plcg2


Anatomical context of Plcg2


Associations of Plcg2 with chemical compounds


Other interactions of Plcg2


  1. A second type of rat phosphoinositide-specific phospholipase C containing a src-related sequence not essential for phosphoinositide-hydrolyzing activity. Emori, Y., Homma, Y., Sorimachi, H., Kawasaki, H., Nakanishi, O., Suzuki, K., Takenawa, T. J. Biol. Chem. (1989) [Pubmed]
  2. Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells. Zhang, J., Berenstein, E.H., Evans, R.L., Siraganian, R.P. J. Exp. Med. (1996) [Pubmed]
  3. Orthovanadate induces translocation of phospholipase C-gamma 1 and -gamma 2 in permeabilized mast cells. Atkinson, T.P., Lee, C.W., Rhee, S.G., Hohman, R.J. J. Immunol. (1993) [Pubmed]
  4. Isolation and characterization of rat 3Y1 fibroblast clones overexpressing the src homology region of phospholipase C-gamma 2. Homma, Y., Emori, Y., Takenawa, T. J. Biol. Chem. (1992) [Pubmed]
  5. The substrate specificity of phosphoinositide-phospholipase C in rat heart sarcolemma. Meij, J.T., Panagia, V. Mol. Cell. Biochem. (1992) [Pubmed]
  6. Translocation of phospholipase C-gamma 2 induced by in vitro activation of protein tyrosine kinase activity in mast cell lysates. Atkinson, T.P., Yang, Q. Cell. Signal. (1996) [Pubmed]
  7. Localization of mRNAs for three novel members (beta 3, beta 4 and gamma 2) of phospholipase C family in mature rat brain. Tanaka, O., Kondo, H. Neurosci. Lett. (1994) [Pubmed]
  8. Purification of recombinant SH2/SH3 proteins of phospholipase C-gamma 1 and -gamma 2 and their inhibitory effect on PIP2-hydrolysis induced by both types of phospholipase C-gamma. Homma, Y., Emori, Y., Takenawa, T. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  9. Attenuation of renomedullary phospholipase C isozyme, PLC-delta 1, in spontaneously hypertensive rats. Lee, K.H., Cho, Y.J., Cha, S.H., Endou, H. Biochem. Mol. Biol. Int. (1997) [Pubmed]
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