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Gene Review

Slc20a2  -  solute carrier family 20 (phosphate...

Rattus norvegicus

Synonyms: Ab1-188, Glvr2, Phosphate transporter 2, PiT-2, Pit-2, ...
 
 
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Disease relevance of Slc20a2

  • We have identified the cellular receptor for amphotropic murine retroviruses, Ram-1, by screening a rat cDNA expression library introduced into amphotropic virus-resistant hamster cells [1].
  • Furthermore, we have constructed Ram-1/Glvr-1 hybrid receptors that allow entry of both GALV and amphotropic virus [2].
 

High impact information on Slc20a2

  • Phosphate uptake was reduced by > 50% in mouse fibroblasts expressing amphotropic envelope glycoprotein, which binds to Ram-1, indicating that Ram-1 is a major phosphate transporter in these cells [3].
  • CHO cells express the hamster homolog of Ram-1 but are resistant to amphotropic retroviruses [4].
  • The induction of Glvr-2 mRNA by Pi was inhibited in the presence of cycloheximide (CHX) [5].
  • These data indicate that extracellular Pi regulates Glvr-2 mRNA expression, provide insights into possible mechanisms whereby Pi may regulate protein phosphorylation, and suggest a potential role for the Pi transporter in rat bone marrow stromal cells [5].
  • On the other hand, there was near absence of gene transfer in untreated rats perfused with rMoMuLV Twenty-four hours after the initial manipulation, abundant expression of Ram-1 mRNA was observed in rat hepatocytes treated with HGF plus T3 [6].
 

Chemical compound and disease context of Slc20a2

  • Our data also reveal that other known Na+/P(i) cotransporter genes, NaPi-2 and Ram-1 (a receptor for amphotropic murine retrovirus), are not regulated by insulin and glucose [7].
 

Biological context of Slc20a2

 

Anatomical context of Slc20a2

 

Associations of Slc20a2 with chemical compounds

  • We tested the effects of extracellular Pi, Ca(2+) and IGF-I on Na(d)Pi transport and Pit-1 or Pit-2 mRNA expression in rat osteoblastic (PyMS) cells [8].
 

Analytical, diagnostic and therapeutic context of Slc20a2

  • The amphotropic retroviral receptor (Ram-1) expression of liver was evaluated at different time points after injecting HGF and T3 by means of Northern blotting using Ram-1 cDNA probe [6].

References

  1. Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus. Miller, D.G., Edwards, R.H., Miller, A.D. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. A family of retroviruses that utilize related phosphate transporters for cell entry. Miller, D.G., Miller, A.D. J. Virol. (1994) [Pubmed]
  3. Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. Kavanaugh, M.P., Miller, D.G., Zhang, W., Law, W., Kozak, S.L., Kabat, D., Miller, A.D. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  4. The envelope glycoprotein of an amphotropic murine retrovirus binds specifically to the cellular receptor/phosphate transporter of susceptible species. Kozak, S.L., Siess, D.C., Kavanaugh, M.P., Miller, A.D., Kabat, D. J. Virol. (1995) [Pubmed]
  5. Extracellular inorganic phosphate regulates gibbon ape leukemia virus receptor-2/phosphate transporter mRNA expression in rat bone marrow stromal cells. Wada, K., Mizuno, M., Komori, T., Tamura, M. J. Cell. Physiol. (2004) [Pubmed]
  6. Enhancement of retrovirus-mediated gene transfer to rat liver in vivo by infusion of hepatocyte growth factor and triiodothyronine. Minami, H., Tada, K., Chowdhury, N.R., Chowdhury, J.R., Onji, M. J. Hepatol. (2000) [Pubmed]
  7. Regulation of rat Na+/Pi cotransporter-1 gene expression: the roles of glucose and insulin. Li, H., Ren, P., Onwochei, M., Ruch, R.J., Xie, Z. Am. J. Physiol. (1996) [Pubmed]
  8. Regulation of phosphate (Pi) transport and NaPi-III transporter (Pit-1) mRNA in rat osteoblasts. Zoidis, E., Ghirlanda-Keller, C., Gosteli-Peter, M., Zapf, J., Schmid, C. J. Endocrinol. (2004) [Pubmed]
  9. Lack of functional Pit-1 and Pit-2 expression on hematopoietic stem cell lines. Thomsen, S., Vogt, B., von Laer, D., Heberlein, C., Rein, A., Ostertag, W., Stocking, C. Acta Haematol. (1998) [Pubmed]
 
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