Gene Review:
Pdx1 - pancreatic and duodenal homeobox 1
Rattus norvegicus
Synonyms:
IDX-1, IPF-1, Idx1, Insulin promoter factor 1, Ipf1, ...
- Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus. Seufert, J., Weir, G.C., Habener, J.F. J. Clin. Invest. (1998)
- mRNA profiling of rat islet tumors reveals nkx 6.1 as a beta-cell-specific homeodomain transcription factor. Jensen, J., Serup, P., Karlsen, C., Nielsen, T.F., Madsen, O.D. J. Biol. Chem. (1996)
- Pdx-1 enables insulin secretion by regulating synaptotagmin 1 gene expression. Nakajima-Nagata, N., Sugai, M., Sakurai, T., Miyazaki, J., Tabata, Y., Shimizu, A. Biochem. Biophys. Res. Commun. (2004)
- Hyperglycaemia and reduced glucokinase expression in weanling offspring from dams maintained on a high-fat diet. Cerf, M.E., Muller, C.J., Du Toit, D.F., Louw, J., Wolfe-Coote, S.A. Br. J. Nutr. (2006)
- Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis. Blume, N., Skouv, J., Larsson, L.I., Holst, J.J., Madsen, O.D. J. Clin. Invest. (1995)
- IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. Miller, C.P., McGehee, R.E., Habener, J.F. EMBO J. (1994)
- Hedgehog signaling regulation of homeodomain protein islet duodenum homeobox-1 expression in pancreatic beta-cells. Thomas, M.K., Lee, J.H., Rastalsky, N., Habener, J.F. Endocrinology (2001)
- Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation. Wang, H., Maechler, P., Ritz-Laser, B., Hagenfeldt, K.A., Ishihara, H., Philippe, J., Wollheim, C.B. J. Biol. Chem. (2001)
- Pdx1, a homeodomain transcription factor required for pancreas development, maps to rat chromosome 12. Yokoi, N., Serikawa, T., Walther, R. Exp. Anim. (1997)
- Notch signaling: a mediator of beta-cell de-differentiation in diabetes? Darville, M.I., Eizirik, D.L. Biochem. Biophys. Res. Commun. (2006)
- High glucose is necessary for complete maturation of Pdx1-VP16-expressing hepatic cells into functional insulin-producing cells. Cao, L.Z., Tang, D.Q., Horb, M.E., Li, S.W., Yang, L.J. Diabetes (2004)
- Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity. Nielsen, K., Kruhøffer, M., Orntoft, T., Sparre, T., Wang, H., Wollheim, C., Jørgensen, M.C., Nerup, J., Karlsen, A.E. Diabetologia (2004)
- Label-retaining cells in the rat pancreas: location and differentiation potential in vitro. Duvillié, B., Attali, M., Aiello, V., Quemeneur, E., Scharfmann, R. Diabetes (2003)
- Differentiation of immature enterocytes into enteroendocrine cells by Pdx1 overexpression. Yamada, S., Kojima, H., Fujimiya, M., Nakamura, T., Kashiwagi, A., Kikkawa, R. Am. J. Physiol. Gastrointest. Liver Physiol. (2001)
- IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetes. Leibowitz, G., Ferber, S., Apelqvist A, n.u.l.l., Edlund, H., Gross, D.J., Cerasi, E., Melloul, D., Kaiser, N. Diabetes (2001)
- Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels. Gremlich, S., Bonny, C., Waeber, G., Thorens, B. J. Biol. Chem. (1997)
- Glucose rapidly and reversibly decreases INS-1 cell insulin gene transcription via decrements in STF-1 and C1 activator transcription factor activity. Olson, L.K., Qian, J., Poitout, V. Mol. Endocrinol. (1998)
- Membrane stabilising effects of natural polyphenols and flavonoids from Sempervivum tectorum on hepatic microsomal mixed-function oxidase system in hyperlipidemic rats. Blázovics, A., Lugasi, A., Kemény, T., Hagymási, K., Kéry, A. Journal of ethnopharmacology. (2000)
- Regulation of ATP-sensitive potassium channel subunit Kir6.2 expression in rat intestinal insulin-producing progenitor cells. Hashimoto, T., Nakamura, T., Maegawa, H., Nishio, Y., Egawa, K., Kashiwagi, A. J. Biol. Chem. (2005)
- The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. Schisler, J.C., Jensen, P.B., Taylor, D.G., Becker, T.C., Knop, F.K., Takekawa, S., German, M., Weir, G.C., Lu, D., Mirmira, R.G., Newgard, C.B. Proc. Natl. Acad. Sci. U.S.A. (2005)
- A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells. Cardozo, A.K., Heimberg, H., Heremans, Y., Leeman, R., Kutlu, B., Kruhøffer, M., Ørntoft, T., Eizirik, D.L. J. Biol. Chem. (2001)
- Silymarin induces recovery of pancreatic function after alloxan damage in rats. Soto, C., Mena, R., Luna, J., Cerbón, M., Larrieta, E., Vital, P., Uría, E., Sánchez, M., Recoba, R., Barrón, H., Favari, L., Lara, A. Life Sci. (2004)
- Expression of stem cell markers and transcription factors during the remodeling of the rat pancreas after duct ligation. Peters, K., Panienka, R., Li, J., Klöppel, G., Wang, R. Virchows Arch. (2005)