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CNOT7  -  CCR4-NOT transcription complex, subunit 7

Homo sapiens

Synonyms: BTG1-binding factor 1, CAF-1, CAF1, CCR4-NOT transcription complex subunit 7, CCR4-associated factor 1, ...
 
 
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Disease relevance of CNOT7

  • Analysis of the transcription regulator, CNOT7, as a candidate chromosome 8 tumor suppressor gene in colorectal cancer [1].
  • Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells [2].
  • BACKGROUND AND PURPOSE: The Caf1 secretion pathway of Yersinia pestis is one of the most well-characterized export machineries [3].
  • CONCLUSION: These results suggested that the recombinant hEGF was successfully secreted through the inner membrane of cells into the periplasm and then through the outer membrane into the medium via the action of the signal peptide of Y. pestis Caf1 in E. coli [3].
 

High impact information on CNOT7

  • We propose that perpetuation of heterochromatin involves self-maintenance factors, including local concentration of Hp1alpha and -beta, and that a degree of plasticity is provided by the cycle of H4 acetylation/deacetylation assisted by CAF-1 [4].
  • Here, we show that fasciata1-4 (fas1-4), a new allele of the Arabidopsis fas1 mutant defective in the p150 subunit of CAF-1, has a severe developmental phenotype, reduced heterochromatin content, and a more open conformation of euchromatin [5].
  • CAF-1 is required in vitro for nucleosome assembly onto newly replicated chromatin in human cells and Arabidopsis thaliana, and defects in yeast (Saccharomyces cerevisiae) affect DNA damage repair processes, predominantly those involved in genome stability [5].
  • CCR4-associated factor CAF1 is an essential factor for spermatogenesis [6].
  • In the periplasm, Caf1M prevents subunit aggregation by capping the extensive hydrophobic surface of activated Caf1 [7].
 

Chemical compound and disease context of CNOT7

  • Protection against virulent plague challenge by the parenteral and aerosol routes was afforded by a single administration of microencapsulated Caf1 and LcrV antigens from Yersinia pestis in BALB/c mice [8].
 

Biological context of CNOT7

 

Anatomical context of CNOT7

  • We showed that CNOT7 is expressed in normal colonic mucosa and in colonic crypt cells, as well as in colorectal cell lines and primary tumors [1].
  • Specific binding of Caf1 [K(d) = (5.4 +/- 0.1) x 10(-10) M] to interleukin-1 receptors (IL-1Rs) on the surface of finite mouse fibroblasts (line NIH 3T3) was observed [11].
  • Thus, these results help to explain the importance of Caf1 in the interaction of Y. pestis with the host immune system [11].
  • Caf1 is able to inhibit high-affinity binding of (125)I-labeled IL-1beta to NIH 3T3 cells, and in the presence of Caf1, the binding of [(125)I]IL-1beta is characterized by a K(d) of (2.0 +/- 0.3) x 10(-9) M [11].
 

Associations of CNOT7 with chemical compounds

  • Strains bearing deletions in either CCR4 or CAF1/POP2, which encode components of the cytoplasmic mRNA deadenylase complex, were particularly sensitive to HU [12].
 

Analytical, diagnostic and therapeutic context of CNOT7

References

  1. Analysis of the transcription regulator, CNOT7, as a candidate chromosome 8 tumor suppressor gene in colorectal cancer. Flanagan, J., Healey, S., Young, J., Whitehall, V., Chenevix-Trench, G. Int. J. Cancer (2003) [Pubmed]
  2. Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells. Vadgama, J.V., Scuric, Z., Chakrabarti, R., Marzo, E., Shen, D., Wu, Y. Int. J. Mol. Med. (2006) [Pubmed]
  3. Secretion of biologically active human epidermal growth factor from Escherichia coli using Yersinia pestis Caf1 signal peptide. Liu, Y.L., Huang, L.M., Lin, W.P., Tsai, C.C., Lin, T.S., Hu, Y.H., Chen, H.S., Han, J.M., Wang, H.J., Liu, Y.T. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. (2006) [Pubmed]
  4. Duplication and maintenance of heterochromatin domains. Taddei, A., Roche, D., Sibarita, J.B., Turner, B.M., Almouzni, G. J. Cell Biol. (1999) [Pubmed]
  5. The Chromatin Assembly Factor Subunit FASCIATA1 Is Involved in Homologous Recombination in Plants. Kirik, A., Pecinka, A., Wendeler, E., Reiss, B. Plant Cell (2006) [Pubmed]
  6. CCR4-associated factor CAF1 is an essential factor for spermatogenesis. Berthet, C., Morera, A.M., Asensio, M.J., Chauvin, M.A., Morel, A.P., Dijoud, F., Magaud, J.P., Durand, P., Rouault, J.P. Mol. Cell. Biol. (2004) [Pubmed]
  7. A novel self-capping mechanism controls aggregation of periplasmic chaperone Caf1M. Zavialov, A.V., Knight, S.D. Mol. Microbiol. (2007) [Pubmed]
  8. Protection against bubonic and pneumonic plague with a single dose microencapsulated sub-unit vaccine. Elvin, S.J., Eyles, J.E., Howard, K.A., Ravichandran, E., Somavarappu, S., Alpar, H.O., Williamson, E.D. Vaccine (2006) [Pubmed]
  9. Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human MUC1 mucin gene: effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene. Ding, L., Lalani, E.N., Reddish, M., Koganty, R., Wong, T., Samuel, J., Yacyshyn, M.B., Meikle, A., Fung, P.Y., Taylor-Papadimitriou, J. Cancer Immunol. Immunother. (1993) [Pubmed]
  10. Mu dI1(Ap lac) mutagenesis of Yersinia pestis plasmid pFra and identification of temperature-regulated loci associated with virulence. Welkos, S.L., Andrews, G.P., Lindler, L.E., Snellings, N.J., Strachan, S.D. Plasmid (2004) [Pubmed]
  11. Structural and functional similarity between Yersinia pestis capsular protein Caf1 and human interleukin-1 beta. Abramov, V.M., Vasiliev, A.M., Vasilenko, R.N., Kulikova, N.L., Kosarev, I.V., Khlebnikov, V.S., Ishchenko, A.T., MacIntyre, S., Gillespie, J.R., Khurana, R., Korpela, T., Fink, A.L., Uversky, V.N. Biochemistry (2001) [Pubmed]
  12. Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length. Woolstencroft, R.N., Beilharz, T.H., Cook, M.A., Preiss, T., Durocher, D., Tyers, M. J. Cell. Sci. (2006) [Pubmed]
  13. Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. Yoshida, Y., Hosoda, E., Nakamura, T., Yamamoto, T. Jpn. J. Cancer Res. (2001) [Pubmed]
  14. Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1. Bogdan, J.A., Adams-Burton, C., Pedicord, D.L., Sukovich, D.A., Benfield, P.A., Corjay, M.H., Stoltenborg, J.K., Dicker, I.B. Biochem. J. (1998) [Pubmed]
 
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