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Mycn  -  v-myc avian myelocytomatosis viral...

Rattus norvegicus

Synonyms: N-myc, N-myc proto-oncogene protein, Nmuc1, Nmyc, Nmyc1
 
 
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Disease relevance of Mycn

 

High impact information on Mycn

  • The effect was specific as very little change was observed in the levels of c-rasHa, c-rasKi, c-myc, and N-myc messenger RNA's. Under the conditions used here, NGF treatment ultimately results in neurite outgrowth, with a reduction or cessation of cell division [2].
  • Disruption of N-myc in neuronal progenitors and other cell types leads to nuclear condensation accompanied by large-scale changes in histone modifications associated with chromatin inactivation, including hypoacetylation and altered methylation [3].
  • No L-myc or N-myc transcripts could be detected in any RNA sample. c-Ha-ras-specific transcripts were essentially unaltered in all RNA samples whereas no c-Ki-ras or N-ras transcripts could be detected throughout the neoplastic process [4].
  • B104, a rat central nervous system-derived cell line and its N-myc gene expressing derivative lines (C6, C7) (Bernards et al., 1986), were stably transfected with the trkA proto-oncogene and independent clones for each cell line were analysed [5].
  • Loss of transcriptional attenuation in N-myc is associated with progression towards a more malignant phenotype [6].
 

Biological context of Mycn

  • The complete nucleotide sequence of a rat genomic DNA fragment of 6.9 kbp containing the entire N-myc gene was determined [7].
  • A unique structural feature of the rat N-myc gene is the presence of two polyadenylation signals in the exon 3 region resulting in formation of two poly(A)+ N-myc mRNAs of 2.9 and 2.2 kb length [7].
  • Transfection of N-myc expression constructs harboring various deletions within the untranslated first exon revealed that a region encoding a potential stem-loop structure followed by a thymine stretch (stem-loop/T region) was required for efficient transcriptional attenuation [6].
  • These results are consistent with the hypothesis that constitutive expression of N-myc inhibits exit from cell cycle and blocks neuronal cell differentiation [5].
  • The absence of detectable N-myc or L-myc expression indicates that Myc function is not absolutely essential for cell viability [8].
 

Anatomical context of Mycn

  • Most significantly, when cell lines generated from overexpression of the intact N-myc expression construct were selected for anchorage-independent growth, a strong block to transcriptional elongation was completely eliminated in all cases examined [6].
  • A high level of N-myc transcript was observed in hepatocytes as early as 1 month after the carcinogen administration, whereas c-myc transcript was detected at a high level only several months later in carcinoma nodules [9].
  • Under stringent conditions, the N-myc DNA probe hybridized with a single 3 kilobase (kb) transcript which was virtually undetectable in ovariectomized rat uteri and increased 6-fold within 15 min after E2 treatment [1].
  • N-myc transactivates RCC1 gene expression in rat fibroblast cells transformed by N-myc and v-ras [10].
  • To investigate the specific role of N-myc in the transformation, we established transformed cell lines that expressed N-myc under a controllable promoter [10].
 

Associations of Mycn with chemical compounds

 

Other interactions of Mycn

  • The TRH effects on N-myc mRNA levels were less consistent [11].
  • In sham-operated control rats, the mRNAs for c-myc, N-myc, c-fos and p53 were present in the anterior cortex, hippocampus, thalamus on both sides, and in the cerebellum, whereas those for s-myc and bcl-2 were not [12].
 

Analytical, diagnostic and therapeutic context of Mycn

  • The levels of N-myc and c-myc mRNAs, which are very low in hepatocytes from normal rats, were increased at least 20-fold within 3 h after partial hepatectomy and decreased rapidly by 6 h [9].
  • N-myc amplification disappeared in very early cultures of the tumour, but it was subsequently detected in MFV-infected cell cultures [13].

References

  1. Estrogen induction of N-myc and c-myc proto-oncogene expression in the rat uterus. Murphy, L.J., Murphy, L.C., Friesen, H.G. Endocrinology (1987) [Pubmed]
  2. Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines. Curran, T., Morgan, J.I. Science (1985) [Pubmed]
  3. Myc influences global chromatin structure. Knoepfler, P.S., Zhang, X.Y., Cheng, P.F., Gafken, P.R., McMahon, S.B., Eisenman, R.N. EMBO J. (2006) [Pubmed]
  4. Poly(A+)RNA levels of growth-, differentiation- and transformation-associated genes in the progressive development of hepatocellular carcinoma in the rat. Huber, B.E., Heilman, C.A., Thorgeirsson, S.S. Hepatology (1989) [Pubmed]
  5. Constitutive N-myc gene expression inhibits trkA mediated neuronal differentiation. Bogenmann, E., Torres, M., Matsushima, H. Oncogene (1995) [Pubmed]
  6. Loss of transcriptional attenuation in N-myc is associated with progression towards a more malignant phenotype. Xu, L., Meng, Y., Wallen, R., DePinho, R.A. Oncogene (1995) [Pubmed]
  7. Different usage of two polyadenylylation signals in transcription of the N-myc gene in rat tumor cells. Sugiyama, A., Miyagi, Y., Shirasawa, Y., Kuchino, Y. Oncogene (1991) [Pubmed]
  8. Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination. Mateyak, M.K., Obaya, A.J., Adachi, S., Sedivy, J.M. Cell Growth Differ. (1997) [Pubmed]
  9. Increased expression of the N-myc gene during normal and neoplastic rat liver growth. Corral, M., Paris, B., Guguen-Guillouzo, C., Corcos, D., Kruh, J., Defer, N. Exp. Cell Res. (1988) [Pubmed]
  10. N-myc transactivates RCC1 gene expression in rat fibroblast cells transformed by N-myc and v-ras. Tsuneoka, M., Mekada, E. J. Biochem. (1998) [Pubmed]
  11. Thyrotropin-releasing hormone increases the levels of c-fos and beta-actin mRNA in GH3/B6 pituitary tumor cells. Weisman, A.S., Tixier-Vidal, A., Gourdji, D. In Vitro Cell. Dev. Biol. (1987) [Pubmed]
  12. Up-regulation of c-myc gene expression following focal ischemia in the rat brain. Nakagomi, T., Asai, A., Kanemitsu, H., Narita, K., Kuchino, Y., Tamura, A., Kirino, T. Neurol. Res. (1996) [Pubmed]
  13. Isolation and initial characterization of a new virus: Micro-Foci inducing virus or MFV. Rovigatti, U. C. R. Acad. Sci. III, Sci. Vie (1992) [Pubmed]
 
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