Gene Review:
Lrrk2 - leucine-rich repeat kinase 2
Rattus norvegicus
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Disease relevance of Lrrk2
- As their broad expression patterns contrast with localized neuropathology in Parkinson's disease, the pathogenicity of clinical mutant forms of PINK1 and LRRK2 may be mediated by nigrostriatal-specific mechanisms [1].
High impact information on Lrrk2
- Weak LRRK2 expression was seen in the hypothalamus, olfactory bulb and substantia nigra [1].
- LRRK2, on the other hand, showed strong regional differences in expression levels with highest levels seen in the striatum, cortex and hippocampus [1].
Analytical, diagnostic and therapeutic context of Lrrk2
- We have mapped the expression of PINK1 and LRRK2 mRNA in the rat and mouse brain via in situ hybridization histochemistry using riboprobes [1].
- We confirmed these distributions for both genes using quantitative RT-PCR and for LRRK2 by western immunoblot [1].
References
- Distribution of PINK1 and LRRK2 in rat and mouse brain. Taymans, J.M., Van den Haute, C., Baekelandt, V. J. Neurochem. (2006) [Pubmed]
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