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Gene Review

Lrrk2  -  leucine-rich repeat kinase 2

Rattus norvegicus

 
 
 
 
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Disease relevance of Lrrk2

  • As their broad expression patterns contrast with localized neuropathology in Parkinson's disease, the pathogenicity of clinical mutant forms of PINK1 and LRRK2 may be mediated by nigrostriatal-specific mechanisms [1].
 

High impact information on Lrrk2

 

Analytical, diagnostic and therapeutic context of Lrrk2

References

  1. Distribution of PINK1 and LRRK2 in rat and mouse brain. Taymans, J.M., Van den Haute, C., Baekelandt, V. J. Neurochem. (2006) [Pubmed]
 
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