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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review: 

hhex  -  hematopoietically expressed homeobox

Danio rerio

 
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High impact information on hhex

  • However, analysis of a hhex deficiency allele shows that hhex is not essential for early endothelial and blood differentiation, suggesting that another gene, perhaps scl, compensates for the absence of Hhex function [1].
  • Further, we show that the boz-mediated induction of hhex is independent of the Boz-mediated repression of bmp2b [2].
  • In zebrafish, Nieuwkoop-center-like activity resides in the dorsal yolk syncytial layer (YSL) at the interface of the vegetal yolk cell and the blastoderm. hex homologs are expressed in the anterior endomesoderm in frogs (Xhex), the anterior visceral endoderm in mice, and the dorsal YSL in zebrafish (hhex) [2].
  • During zebrafish development, the thyroid primordium initiates expression of molecular markers such as hhex and nk2.1a in the endoderm prior to pharynx formation [3].
  • In zebrafish, the onset of liver specification is marked by the localized endodermal expression of hhex and prox1 at 22 hours post fertilization [4].
 

Biological context of hhex

 

Other interactions of hhex

  • Furthermore, we find that hhex and scl can induce each other's expression, suggesting that these two genes cross-regulate each other during early endothelial and blood differentiation [1].

References

  1. Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish. Liao, W., Ho, C.Y., Yan, Y.L., Postlethwait, J., Stainier, D.Y. Development (2000)
  2. Regulation of hhex expression in the yolk syncytial layer, the potential Nieuwkoop center homolog in zebrafish. Bischof, J., Driever, W. Dev. Biol. (2004)
  3. Zebrafish hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors. Elsalini, O.A., von Gartzen, J., Cramer, M., Rohr, K.B. Dev. Biol. (2003)
  4. Mesodermal Wnt2b signalling positively regulates liver specification. Ober, E.A., Verkade, H., Field, H.A., Stainier, D.Y. Nature (2006)
 
 
 
 
 
 
 
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