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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Gene: gdf6a  -  growth differentiation factor 6a

Danio rerio

Synonyms: cb278, gdf6b, radar, rdr, sb:cb278
 
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High impact information on gdf6a

  • Maternal induction of bmps by Radar is essential for zebrafish development as its removal results in larval-lethal dorsalized phenotypes [1].
  • We show that Radar ventralizes zebrafish embryos and induces the early expression of bmp2b and bmp4 [2].
  • We provide evidence here that a maternally expressed bone morphogenetic protein (BMP), Radar, may control early ventral specification in zebrafish [2].
  • The pattern of expression of Radar suggested a possible involvement in several induction steps during embryogenesis including in the dorsal neural tube, red blood cells, the dorsal fin and the retina [3].
  • Taken together these results suggest that Radar could be involved in maintaining the identity of cells of the dorsal-most neural tube and of at least a subset of neural crest cells [3].
 

Biological context of gdf6a

  • In an effort to identify new members of this superfamily involved in the control of early zebrafish embryogenesis, we have isolated a gene, Radar, which appears to be conserved throughout vertebrate evolution and defines a new subfamily within the superfamily [4].
 

Anatomical context of gdf6a

  • Its pattern of expression suggests that Radar plays a role in the dorso-ventral polarity of the neural plate, blood islands formation, blood cells differentiation, the establishment of retinal dorso-ventral polarity and/or proper axonal retinotectal projections [4].

References

  1. Maternal induction of ventral fate by zebrafish radar. Sidi, S., Goutel, C., Peyriéras, N., Rosa, F.M. Proc. Natl. Acad. Sci. U.S.A. (2003)
  2. The ventralizing activity of Radar, a maternally expressed bone morphogenetic protein, reveals complex bone morphogenetic protein interactions controlling dorso-ventral patterning in zebrafish. Goutel, C., Kishimoto, Y., Schulte-Merker, S., Rosa, F. Mech. Dev. (2000)
  3. The BMP-related protein radar: a maintenance factor for dorsal neuroectoderm cells? Délot, E., Kataoka, H., Goutel, C., Yan, Y.L., Postlethwait, J., Wittbrodt, J., Rosa, F.M. Mech. Dev. (1999)
  4. Zebrafish Radar: a new member of the TGF-beta superfamily defines dorsal regions of the neural plate and the embryonic retina. Rissi, M., Wittbrodt, J., Délot, E., Naegeli, M., Rosa, F.M. Mech. Dev. (1995)
 
 
 
 
 
 
 
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