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Gene Review: 

ptch1  -  patched 1

Danio rerio

Synonyms: lep, ptc1, ptc2
 
 
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High impact information on ptc2

  • A gene encoding a receptor for the hedgehog protein, ptc-2, is expressed by retinal neuroepithelial cells [1].
  • We find that at the sequence level Zf-ptc2 is more closely related than Zf-ptc1 to the ptc genes initially characterised in other vertebrate species [2].
 

Biological context of ptc2

  • Although this suggested an involvement of Hh signaling in TCDD-mediated impairment of jaw growth, we did not observe downregulation of ptc1 and ptc2, receptors dependent on Hh signaling [3].

References

  1. Function for Hedgehog genes in zebrafish retinal development. Stenkamp, D.L., Frey, R.A., Prabhudesai, S.N., Raymond, P.A. Dev. Biol. (2000) [Pubmed]
  2. Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to Hedgehog signalling. Lewis, K.E., Concordet, J.P., Ingham, P.W. Dev. Biol. (1999) [Pubmed]
  3. Impairment of lower jaw growth in developing zebrafish exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and reduced hedgehog expression. Teraoka, H., Dong, W., Okuhara, Y., Iwasa, H., Shindo, A., Hill, A.J., Kawakami, A., Hiraga, T. Aquat. Toxicol. (2006) [Pubmed]
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