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Gene: ptc2  -  patched 2

Danio rerio

Synonyms: patched2
 
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High impact information on ptc2

  • A gene encoding a receptor for the hedgehog protein, ptc-2, is expressed by retinal neuroepithelial cells [1].
  • We find that at the sequence level Zf-ptc2 is more closely related than Zf-ptc1 to the ptc genes initially characterised in other vertebrate species [2].
 

Biological context of ptc2

  • Although this suggested an involvement of Hh signaling in TCDD-mediated impairment of jaw growth, we did not observe downregulation of ptc1 and ptc2, receptors dependent on Hh signaling [3].

References

  1. Function for Hedgehog genes in zebrafish retinal development. Stenkamp, D.L., Frey, R.A., Prabhudesai, S.N., Raymond, P.A. Dev. Biol. (2000)
  2. Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to Hedgehog signalling. Lewis, K.E., Concordet, J.P., Ingham, P.W. Dev. Biol. (1999)
  3. Impairment of lower jaw growth in developing zebrafish exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and reduced hedgehog expression. Teraoka, H., Dong, W., Okuhara, Y., Iwasa, H., Shindo, A., Hill, A.J., Kawakami, A., Hiraga, T. Aquat. Toxicol. (2006)
 
 
 
 
 
 
 
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