Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

egr2b - early growth response 2b

Danio rerio

Oxtoby, E., Eroglu, B., Yan, Y.L., Maves, L., Walshe, J., et al.

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High impact information on egr2b

First, vhnf1 promotes r5+r6 identity through an obligate synergy with Fgf signals to activate valentino and krox20 expression [1].
Widespread overexpression of Pou2 can rescue the segmental krx20 and val domains in spg mutants, but does not induce ectopic expression of these genes [2].
The latter being established through differential expression of a hierarchy of transcription factors, including Hox genes, Krox20, and Kreisler/Valentino [3].
Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development [4].
To begin to examine the function of genes that control early development in the hindbrain, we have screened an embryonic zebrafish cDNA library with a murine krox-20 gene probe that contained the conserved zinc finger regions [4].

Biological context of egr2b

Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse [5].
Treatments with retinoic acid produced a phenotype similar to that of ectopic hoxb2 expression, including ectopic krx20 (but not valentino) expression in the eye, and fusion of cartilages from pharyngeal arches 1 and 2 [6].
A novel zinc finger transcription factor resembles krox-20 in structure and in expression pattern in zebrafish [7].

Anatomical context of egr2b

Furthermore, in the absence of functional rbmx, expression of specific markers for the fore- and hindbrain (otx2, krox20) was severely reduced [8].

Other interactions of egr2b

The identity of each rhombomere is specified by the expression of conserved transcription factors, including Krox-20, vHnf1, Val (Kreisler, Mafb) and several Hox proteins [9].
Double in situ hybridization with krox20 and cyp26d1 reveals that cyp26d1 is expressed in presumptive rhombomere 2-4 (r2-r4) at 2-somite stage [10].
Our results indicate that reduction in Brg1 expression leads to the expansion of the forebrain-specific transcription factor, six3, and marked reduction in expression of the mid/hind-brain boundary and hind-brain genes, engrailed2 and krox20, respectively [11].

References

vhnf1 and Fgf signals synergize to specify rhombomere identity in the zebrafish hindbrain. Wiellette, E.L., Sive, H. Development (2003)
spiel ohne grenzen/pou2 is required for zebrafish hindbrain segmentation. Hauptmann, G., Belting, H.G., Wolke, U., Lunde, K., Söll, I., Abdelilah-Seyfried, S., Prince, V., Driever, W. Development (2002)
Establishment of hindbrain segmental identity requires signaling by FGF3 and FGF8. Walshe, J., Maroon, H., McGonnell, I.M., Dickson, C., Mason, I. Curr. Biol. (2002)
Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development. Oxtoby, E., Jowett, T. Nucleic Acids Res. (1993)
Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse. Grose, R., Harris, B.S., Cooper, L., Topilko, P., Martin, P. Dev. Dyn. (2002)
Ectopic expression of hoxb2 after retinoic acid treatment or mRNA injection: disruption of hindbrain and craniofacial morphogenesis in zebrafish embryos. Yan, Y.L., Jowett, T., Postlethwait, J.H. Dev. Dyn. (1998)
A novel zinc finger transcription factor resembles krox-20 in structure and in expression pattern in zebrafish. Sun, Z., Shi, K., Su, Y., Meng, A. Mech. Dev. (2002)
RBMX gene is essential for brain development in zebrafish. Tsend-Ayush, E., O'Sullivan, L.A., Grützner, F.S., Onnebo, S.M., Lewis, R.S., Delbridge, M.L., Marshall Graves, J.A., Ward, A.C. Dev. Dyn. (2005)
Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acid. Maves, L., Kimmel, C.B. Dev. Biol. (2005)
Molecular cloning and expression of a novel CYP26 gene (cyp26d1) during zebrafish early development. Gu, X., Xu, F., Wang, X., Gao, X., Zhao, Q. Gene Expr. Patterns (2005)
Critical role of Brg1 member of the SWI/SNF chromatin remodeling complex during neurogenesis and neural crest induction in zebrafish. Eroglu, B., Wang, G., Tu, N., Sun, X., Mivechi, N.F. Dev. Dyn. (2006)