Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene: pou1 - POU domain gene 1

Danio rerio

Synonyms: POU domain protein 1, ZFPOU1

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Matsuzaki, T., Takeda, H., Verrijzer, C.P., Johansen, T., Sampath, K., et al.

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Disease relevance of pou1

In addition, the ubiquitous POU transcription factor Oct-1 or its isolated POU domain enhances adenovirus DNA replication [1].

High impact information on pou1

In contrast to the Pou2 product, the t-Pou2 product lacks DNA-binding activity because of its incomplete POU domain structure [2].
POU domain proteins are a large family of transcriptional regulatory proteins, many of which are implicated in the control of gene expression during early development [2].
The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesis [3].
We report the characterization of the zebrafish zp-50 class III POU domain gene [4].
The Pou domain transcription factor Pit-1 is required for lineage determination and cellular commitment processes during mammalian adenohypophysis development [5].

Biological context of pou1

Northern blot analysis revealed that the ZFPOU1 transcripts first appeared at the early neurula stage of embryogenesis and transiently increased thereafter [6].
The ZFPOU1 cDNA contained an open reading frame encoding a 425 amino acid peptide [6].
The deduced amino acid sequence of the reading frame was most similar to that of the mouse class III POU-domain gene, Brain-1 [6].
We have isolated a POU domain-containing cDNA (ZFPOU1) from a cDNA library of zebrafish (Brachydanio rerio) [6].
Genetic data have demonstrated that some POU domain proteins are essential for the proliferation of specific cell types, suggesting a possible role in DNA replication [1].

Anatomical context of pou1

The POU domain protein spg (pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein casanova [7].

Associations of pou1 with chemical compounds

The 453 amino acids long region N-terminal to the POU domain contains several features typical of transcriptional activation domains such as an acidic region with a putative amphipathic alpha-helix, a glutamine-rich region, and short threonine- and/or serine-rich regions [8].

Other interactions of pou1

The expression of brn-3b in the mechanosensory lateral line of fish suggests a conserved function of a class IV POU domain transcription factor in sensory system development [9].

Analytical, diagnostic and therapeutic context of pou1

In situ hybridization analysis demonstrated that the ZFPOU1 transcripts were localized in the neural tissues of embryos, but not in mesodermal, endodermal or ectodermal tissues [6].
Using redundant primers in a PCR based cloning strategy, POU-domain encoding sequences representing two different class III genes (brain-1.1, brain-1.2) and one class IV gene (brain-3.1) were identified in zebrafish [10].

References

POU domain transcription factors from different subclasses stimulate adenovirus DNA replication. Verrijzer, C.P., Strating, M., Mul, Y.M., van der Vliet, P.C. Nucleic Acids Res. (1992)
A novel POU domain gene, zebrafish pou2: expression and roles of two alternatively spliced twin products in early development. Takeda, H., Matsuzaki, T., Oki, T., Miyagawa, T., Amanuma, H. Genes Dev. (1994)
The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesis. Burgess, S., Reim, G., Chen, W., Hopkins, N., Brand, M. Development (2002)
Complex expression of the zp-50 pou gene in the embryonic zebrafish brain is altered by overexpression of sonic hedgehog. Hauptmann, G., Gerster, T. Development (1996)
Zebrafish pit1 mutants lack three pituitary cell types and develop severe dwarfism. Nica, G., Herzog, W., Sonntag, C., Hammerschmidt, M. Mol. Endocrinol. (2004)
A POU-domain gene of zebrafish, ZFPOU1, specifically expressed in the developing neural tissues. Matsuzaki, T., Amanuma, H., Takeda, H. Biochem. Biophys. Res. Commun. (1992)
The POU domain protein spg (pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein casanova. Reim, G., Mizoguchi, T., Stainier, D.Y., Kikuchi, Y., Brand, M. Dev. Cell (2004)
Zebrafish pou[c]: a divergent POU family gene ubiquitously expressed during embryogenesis. Johansen, T., Moens, U., Holm, T., Fjose, A., Krauss, S. Nucleic Acids Res. (1993)
Developmental expression of the POU domain transcription factor Brn-3b (Pou4f2) in the lateral line and visual system of zebrafish. DeCarvalho, A.C., Cappendijk, S.L., Fadool, J.M. Dev. Dyn. (2004)
Developmental expression of class III and IV POU domain genes in the zebrafish. Sampath, K., Stuart, G.W. Biochem. Biophys. Res. Commun. (1996)