Gene Review:
HGF - hepatocyte growth factor (hepapoietin A;...
Homo sapiens
Synonyms:
DFNB39, F-TCF, HGFB, HPTA, Hepatocyte growth factor, ...
- Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic CDK4 mutation. Tormo, D., Ferrer, A., Gaffal, E., Wenzel, J., Basner-Tschakarjan, E., Steitz, J., Heukamp, L.C., Gütgemann, I., Buettner, R., Malumbres, M., Barbacid, M., Merlino, G., Tüting, T. Am. J. Pathol. (2006)
- The hepatocyte growth factor regulatory factors in human breast cancer. Parr, C., Watkins, G., Mansel, R.E., Jiang, W.G. Clin. Cancer Res. (2004)
- Hepatocyte growth factor activation inhibitors (HAI-1 and HAI-2) regulate HGF-induced invasion of human breast cancer cells. Parr, C., Jiang, W.G. Int. J. Cancer (2006)
- CD44-independent hepatocyte growth factor/c-Met autocrine loop promotes malignant peripheral nerve sheath tumor cell invasion in vitro. Su, W., Gutmann, D.H., Perry, A., Abounader, R., Laterra, J., Sherman, L.S. Glia (2004)
- Predictive value of plasma hepatocyte growth factor/scatter factor levels in patients with clinically localized prostate cancer. Gupta, A., Karakiewicz, P.I., Roehrborn, C.G., Lotan, Y., Zlotta, A.R., Shariat, S.F. Clin. Cancer Res. (2008)
- Hepatocyte growth factor (HGF/SF) in Alzheimer's disease. Fenton, H., Finch, P.W., Rubin, J.S., Rosenberg, J.M., Taylor, W.G., Kuo-Leblanc, V., Rodriguez-Wolf, M., Baird, A., Schipper, H.M., Stopa, E.G. Brain Res. (1998)
- Hepatocyte growth factor/scatter factor and its receptor c-Met are overexpressed and associated with an increased microvessel density in malignant pleural mesothelioma. Tolnay, E., Kuhnen, C., Wiethege, T., König, J.E., Voss, B., Müller, K.M. J. Cancer Res. Clin. Oncol. (1998)
- A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Ponzetto, C., Bardelli, A., Zhen, Z., Maina, F., dalla Zonca, P., Giordano, S., Graziani, A., Panayotou, G., Comoglio, P.M. Cell (1994)
- The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met. Petrelli, A., Gilestro, G.F., Lanzardo, S., Comoglio, P.M., Migone, N., Giordano, S. Nature (2002)
- Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Stoker, M., Gherardi, E., Perryman, M., Gray, J. Nature (1987)
- Identification of a competitive HGF antagonist encoded by an alternative transcript. Chan, A.M., Rubin, J.S., Bottaro, D.P., Hirschfield, D.W., Chedid, M., Aaronson, S.A. Science (1991)
- How to make tubes: signaling by the Met receptor tyrosine kinase. Rosário, M., Birchmeier, W. Trends Cell Biol. (2003)
- Chronic exposure to fulvestrant promotes overexpression of the c-Met receptor in breast cancer cells: implications for tumour-stroma interactions. Hiscox, S., Jordan, N.J., Jiang, W., Harper, M., McClelland, R., Smith, C., Nicholson, R.I. Endocr. Relat. Cancer (2006)
- Immunohistochemical expression of hepatocyte growth factor and c-Met/HGF receptor in benign and malignant human prostate tissue. Nakashiro, K., Hayashi, Y., Oyasu, R. Oncol. Rep. (2003)
- Altered gene expression pattern in cultured human breast cancer cells treated with hepatocyte growth factor/scatter factor in the setting of DNA damage. Yuan, R., Fan, S., Achary, M., Stewart, D.M., Goldberg, I.D., Rosen, E.M. Cancer Res. (2001)
- Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents. Fan, S., Wang, J.A., Yuan, R.Q., Rockwell, S., Andres, J., Zlatapolskiy, A., Goldberg, I.D., Rosen, E.M. Oncogene (1998)
- Cooperative interaction between alpha- and beta-chains of hepatocyte growth factor on c-Met receptor confers ligand-induced receptor tyrosine phosphorylation and multiple biological responses. Matsumoto, K., Kataoka, H., Date, K., Nakamura, T. J. Biol. Chem. (1998)
- Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL. Sakkab, D., Lewitzky, M., Posern, G., Schaeper, U., Sachs, M., Birchmeier, W., Feller, S.M. J. Biol. Chem. (2000)
- Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells. Yamamoto, N., Mammadova, G., Song, R.X., Fukami, Y., Sato, K. J. Cell. Sci. (2006)
- Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea. Wilson, S.E., Walker, J.W., Chwang, E.L., He, Y.G. Invest. Ophthalmol. Vis. Sci. (1993)
- NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells. Maehara, N., Matsumoto, K., Kuba, K., Mizumoto, K., Tanaka, M., Nakamura, T. Br. J. Cancer (2001)
- Interleukin-6- and tumour necrosis factor alpha-mediated expression of hepatocyte growth factor by stromal cells and its involvement in the growth of endometriosis. Khan, K.N., Masuzaki, H., Fujishita, A., Kitajima, M., Hiraki, K., Sekine, I., Matsuyama, T., Ishimaru, T. Hum. Reprod. (2005)
- Hepatocyte growth factor stimulates the invasion of gallbladder carcinoma cell lines in vitro. Li, H., Shimura, H., Aoki, Y., Date, K., Matsumoto, K., Nakamura, T., Tanaka, M. Clin. Exp. Metastasis (1998)
- Hepatocyte growth factor levels in liver and blood, and post-operative liver cell proliferation in patients with benign and malignant liver tumors after partial hepatectomy. Dłuzniewska, J., Zolich, D., Polański, J., Zajac, L., Sitkiewicz, D., Łukomska, B. Med. Sci. Monit. (2002)
- The binding properties of minimal oligosaccharides reveal a common heparan sulfate/dermatan sulfate-binding site in hepatocyte growth factor/scatter factor that can accommodate a wide variety of sulfation patterns. Deakin, J.A., Blaum, B.S., Gallagher, J.T., Uhrín, D., Lyon, M. J. Biol. Chem. (2009)
- HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor. Date, K., Matsumoto, K., Shimura, H., Tanaka, M., Nakamura, T. FEBS Lett. (1997)
- Hepatocyte growth factor plasma levels after myocardial infarction are not affected by recombinant tissue-type plasminogen-activator therapy. Molnar, C., Buratti, T., Wiedermann, C.J., Tilg, H. Eur. Cytokine Netw. (2000)
- Scatter factor binds to thrombospondin and other extracellular matrix components. Lamszus, K., Joseph, A., Jin, L., Yao, Y., Chowdhury, S., Fuchs, A., Polverini, P.J., Goldberg, I.D., Rosen, E.M. Am. J. Pathol. (1996)
- Regulation of matrix metalloproteinase-2 (MMP-2) by hepatocyte growth factor/scatter factor (HGF/SF) in human glioma cells: HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane type-1 MMP. Hamasuna, R., Kataoka, H., Moriyama, T., Itoh, H., Seiki, M., Koono, M. Int. J. Cancer (1999)
- Expression of hepatocyte growth factor/scatter factor and c-Met in human dental papilla and fibroblasts from dental papilla. Kajihara, T., Ohnishi, T., Arakaki, N., Semba, I., Daikuhara, Y. Arch. Oral Biol. (1999)
- Expression of hepatocyte growth factor/scatter factor and its receptor c-Met in brain tumors: evidence for a role in progression of astrocytic tumors (Review). Moriyama, T., Kataoka, H., Koono, M., Wakisaka, S. Int. J. Mol. Med. (1999)
- Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium. Panos, R.J., Rubin, J.S., Csaky, K.G., Aaronson, S.A., Mason, R.J. J. Clin. Invest. (1993)
- Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells. Ridley, A.J., Comoglio, P.M., Hall, A. Mol. Cell. Biol. (1995)
- Scatter factor/hepatocyte growth factor stimulation of glioblastoma cell cycle progression through G(1) is c-Myc dependent and independent of p27 suppression, Cdk2 activation, or E2F1-dependent transcription. Walter, K.A., Hossain, M.A., Luddy, C., Goel, N., Reznik, T.E., Laterra, J. Mol. Cell. Biol. (2002)
- Liver regeneration: molecular mechanisms of growth control. Michalopoulos, G.K. FASEB J. (1990)
- Suppression of adriamycin-induced apoptosis by sustained activation of the phosphatidylinositol-3'-OH kinase-Akt pathway. Takeuchi, K., Ito, F. J. Biol. Chem. (2004)
- Human progenitor cells from bone marrow or adipose tissue produce VEGF, HGF, and IGF-I in response to TNF by a p38 MAPK-dependent mechanism. Wang, M., Crisostomo, P.R., Herring, C., Meldrum, K.K., Meldrum, D.R. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006)
- Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing. Neuss, S., Becher, E., Wöltje, M., Tietze, L., Jahnen-Dechent, W. Stem Cells (2004)
- Transfection of human hepatocyte growth factor gene ameliorates secondary lymphedema via promotion of lymphangiogenesis. Saito, Y., Nakagami, H., Morishita, R., Takami, Y., Kikuchi, Y., Hayashi, H., Nishikawa, T., Tamai, K., Azuma, N., Sasajima, T., Kaneda, Y. Circulation (2006)