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EHD4  -  EH-domain containing 4

Homo sapiens

Synonyms: EH domain-containing protein 4, FKSG7, HCA10, HCA11, Hepatocellular carcinoma-associated protein 10/11, ...
 
 
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High impact information on EHD4

  • Embryonic rat limb cartilage was strongly stained throughout development, and cultured fibroblasts deposited an extracellular filamentous network containing EHD4 [1].
  • EHD1, EHD2 and EHD4 have also been implicated in the internalization of receptors and their transport to early endosomes [2].
 

Anatomical context of EHD4

  • Knock-down analyses indicated that EHD1 and 2 regulate the exit of cargo from the recycling endosome while EHD4, similar to that reported for EHD3 (Naslavsky et al. (2006) Mol. Biol. Cell 17, 163), regulates transport from the early endosome to the recycling endosome [3].
  • EHD1 and EHD4 control recycling by regulating the transport of receptors from the recycling compartment to the plasma membrane [2].

References

  1. Characterization of EHD4, an EH domain-containing protein expressed in the extracellular matrix. Kuo, H.J., Tran, N.T., Clary, S.A., Morris, N.P., Glanville, R.W. J. Biol. Chem. (2001) [Pubmed]
  2. C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH? Naslavsky, N., Caplan, S. J. Cell. Sci. (2005) [Pubmed]
  3. Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans. George, M., Ying, G., Rainey, M.A., Solomon, A., Parikh, P.T., Gao, Q., Band, V., Band, H. BMC Cell Biol. (2007) [Pubmed]
 
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