Gene Review:
HIF1A - hypoxia inducible factor 1, alpha subunit...
Homo sapiens
Synonyms:
ARNT-interacting protein, BHLHE78, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, HIF-1-alpha, ...
Berra,
Minet,
Werner Solbach,
Volmat,
Roux,
Semenza,
Joos,
Matthias Klinger,
Gustafsson,
Ernest,
Remacle,
Michiels,
Kaluzová,
Ameln,
Sundberg,
Werkmeister,
Shibasaki,
Ger van Zandbergen,
Okamoto,
Tamamizu-Kato,
Kato,
Pouysségur,
Jansson,
Jens Gieffers,
Brandt,
Stanbridge,
Makino,
Hiroshi Harada,
Satoshi Itasaka,
Shinae Kizaka-Kondoh,
Keiko Shibuya,
Akiyo Morinibu,
Kazumi Shinomiya,
Masahiro Hiraoka,
Jan Rupp,
Poellinger,
Fillies,
Roland,
Ginouvès,
Buerger,
Thomas Hellwig-Burgel,
Kaluz,
Benizri,
Raes,
Robert Wrase,
van Diest,
Matthias Maass,
Michel,
Joerg Deiwick,
- Dynamic HIF1A regulation during human placental development. Ietta, F., Wu, Y., Winter, J., Xu, J., Wang, J., Post, M., Caniggia, I. Biol. Reprod. (2006)
- Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer. Koukourakis, M.I., Giatromanolaki, A., Sivridis, E., Simopoulos, C., Turley, H., Talks, K., Gatter, K.C., Harris, A.L. Int. J. Radiat. Oncol. Biol. Phys. (2002)
- HIF1A gene transcription is dependent on a core promoter sequence encompassing activating and inhibiting sequences located upstream from the transcription initiation site and cis elements located within the 5'UTR. Minet, E., Ernest, I., Michel, G., Roland, I., Remacle, J., Raes, M., Michiels, C. Biochem. Biophys. Res. Commun. (1999)
- Polymorphisms in the hypoxia inducible factor-1alpha gene (HIF1A) are associated with the renal cell carcinoma phenotype. Ollerenshaw, M., Page, T., Hammonds, J., Demaine, A. Cancer Genet. Cytogenet. (2004)
- Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. Bos, R., Zhong, H., Hanrahan, C.F., Mommers, E.C., Semenza, G.L., Pinedo, H.M., Abeloff, M.D., Simons, J.W., van Diest, P.J., van der Wall, E. J. Natl. Cancer Inst. (2001)
- Chlamydia pneumoniae directly interferes with HIF-1alpha stabilization in human host cells. Rupp, J., Gieffers, J., Klinger, M., van Zandbergen, G., Wrase, R., Maass, M., Solbach, W., Deiwick, J., Hellwig-Burgel, T. Cell. Microbiol. (2007)
- Physiological activation of hypoxia inducible factor-1 in human skeletal muscle. Ameln, H., Gustafsson, T., Sundberg, C.J., Okamoto, K., Jansson, E., Poellinger, L., Makino, Y. FASEB J. (2005)
- Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Bos, R., van der Groep, P., Greijer, A.E., Shvarts, A., Meijer, S., Pinedo, H.M., Semenza, G.L., van Diest, P.J., van der Wall, E. Cancer (2003)
- HIF1-alpha overexpression indicates a good prognosis in early stage squamous cell carcinomas of the oral floor. Fillies, T., Werkmeister, R., van Diest, P.J., Brandt, B., Joos, U., Buerger, H. BMC Cancer (2005)
- Is the hypoxia-inducible factor-1 alpha mRNA expression activated by ethanol-induced injury, the mechanism underlying alcoholic liver disease? Li, L., Chen, S.H., Zhang, Y., Yu, C.H., Li, S.D., Li, Y.M. HBPD INT (2006)
- Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein. Corn, P.G., McDonald, E.R., Herman, J.G., El-Deiry, W.S. Nat. Genet. (2003)
- Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. Jeong, J.W., Bae, M.K., Ahn, M.Y., Kim, S.H., Sohn, T.K., Bae, M.H., Yoo, M.A., Song, E.J., Lee, K.J., Kim, K.W. Cell (2002)
- HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Semenza, G.L. Cell (2001)
- Bimodal effect of hypoxia in cancer: role of hypoxia inducible factor in apoptosis. Wang, Y., Pakunlu, R.I., Tsao, W., Pozharov, V., Minko, T. Mol. Pharm. (2004)
- Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP. Sang, N., Fang, J., Srinivas, V., Leshchinsky, I., Caro, J. Mol. Cell. Biol. (2002)
- Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite. Duyndam, M.C., Hulscher, S.T., van der Wall, E., Pinedo, H.M., Boven, E. J. Biol. Chem. (2003)
- HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Gray, M.J., Zhang, J., Ellis, L.M., Semenza, G.L., Evans, D.B., Watowich, S.S., Gallick, G.E. Oncogene (2005)
- Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1alpha expression through activation of AKT and P70S6K1 in human ovarian cancer cells. Liu, L.Z., Hu, X.W., Xia, C., He, J., Zhou, Q., Shi, X., Fang, J., Jiang, B.H. Free Radic. Biol. Med. (2006)
- Structural and functional analysis of hypoxia-inducible factor 1. Semenza, G.L., Agani, F., Booth, G., Forsythe, J., Iyer, N., Jiang, B.H., Leung, S., Roe, R., Wiener, C., Yu, A. Kidney Int. (1997)
- The human hypoxia-inducible factor 1alpha gene: HIF1A structure and evolutionary conservation. Iyer, N.V., Leung, S.W., Semenza, G.L. Genomics (1998)
- Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q. Semenza, G.L., Rue, E.A., Iyer, N.V., Pang, M.G., Kearns, W.G. Genomics (1996)
- Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1 alpha. Wakisaka, N., Kondo, S., Yoshizaki, T., Murono, S., Furukawa, M., Pagano, J.S. Mol. Cell. Biol. (2004)
- Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization. Zheng, X., Ruas, J.L., Cao, R., Salomons, F.A., Cao, Y., Poellinger, L., Pereira, T. Mol. Cell. Biol. (2006)
- Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1alpha expression. Bárdos, J.I., Chau, N.M., Ashcroft, M. Mol. Cell. Biol. (2004)
- Induction of plasminogen activator inhibitor I gene expression by intracellular calcium via hypoxia-inducible factor-1. Liu, Q., Möller, U., Flügel, D., Kietzmann, T. Blood (2004)
- Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1alpha C-terminal activation domain. Kaluz, S., Kaluzová, M., Stanbridge, E.J. Mol. Cell. Biol. (2006)
- Hypoxia-inducible factor 1 alpha in clear cell renal cell carcinoma. Klatte, T., Seligson, D.B., Riggs, S.B., Leppert, J.T., Berkman, M.K., Kleid, M.D., Yu, H., Kabbinavar, F.F., Pantuck, A.J., Belldegrun, A.S. Clin. Cancer Res. (2007)
- Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells. Tang, X., Zhang, Q., Nishitani, J., Brown, J., Shi, S., Le, A.D. Clin. Cancer Res. (2007)
- The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors. Harada, H., Itasaka, S., Kizaka-Kondoh, S., Shibuya, K., Morinibu, A., Shinomiya, K., Hiraoka, M. J. Biol. Chem. (2009)
- Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. Tanimoto, K., Makino, Y., Pereira, T., Poellinger, L. EMBO J. (2000)
- Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT. Zelzer, E., Levy, Y., Kahana, C., Shilo, B.Z., Rubinstein, M., Cohen, B. EMBO J. (1998)
- Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity. Kato, H., Tamamizu-Kato, S., Shibasaki, F. J. Biol. Chem. (2004)
- Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia. Suzuki, H., Tomida, A., Tsuruo, T. Oncogene (2001)
- Suppression of the dual-specificity phosphatase MKP-1 enhances HIF-1 trans-activation and increases expression of EPO. Liu, C., Shi, Y., Han, Z., Pan, Y., Liu, N., Han, S., Chen, Y., Lan, M., Qiao, T., Fan, D. Biochem. Biophys. Res. Commun. (2003)
- VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha. Li, Z., Wang, D., Messing, E.M., Wu, G. EMBO Rep. (2005)
- The zinc chelator, N,N,N',N'-tetrakis (2-pyridylmethyl) ethylenediamine, increases the level of nonfunctional HIF-1alpha protein in normoxic cells. Choi, S.M., Choi, K.O., Lee, N., Oh, M., Park, H. Biochem. Biophys. Res. Commun. (2006)
- Expression of hypoxia-inducible transcription factors in developing human and rat kidneys. Bernhardt, W.M., Schmitt, R., Rosenberger, C., Münchenhagen, P.M., Gröne, H.J., Frei, U., Warnecke, C., Bachmann, S., Wiesener, M.S., Willam, C., Eckardt, K.U. Kidney Int. (2006)
- Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway. Carroll, V.A., Ashcroft, M. Cancer Res. (2006)
- Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis. Gomez-Manzano, C., Fueyo, J., Jiang, H., Glass, T.L., Lee, H.Y., Hu, M., Liu, J.L., Jasti, S.L., Liu, T.J., Conrad, C.A., Yung, W.K. Ann. Neurol. (2003)
- Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1. To, K.K., Huang, L.E. J. Biol. Chem. (2005)
- The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism. Tang, T.T., Lasky, L.A. J. Biol. Chem. (2003)
- Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha. Baek, J.H., Liu, Y.V., McDonald, K.R., Wesley, J.B., Zhang, H., Semenza, G.L. J. Biol. Chem. (2007)
- Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. Ema, M., Hirota, K., Mimura, J., Abe, H., Yodoi, J., Sogawa, K., Poellinger, L., Fujii-Kuriyama, Y. EMBO J. (1999)
- HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. Berra, E., Benizri, E., Ginouvès, A., Volmat, V., Roux, D., Pouysségur, J. EMBO J. (2003)
- DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX. Kaluzová, M., Kaluz, S., Lerman, M.I., Stanbridge, E.J. Mol. Cell. Biol. (2004)
- Inflammatory levels of nitric oxide inhibit airway epithelial cell migration by inhibition of the kinase ERK1/2 and activation of hypoxia-inducible factor-1 alpha. Bove, P.F., Hristova, M., Wesley, U.V., Olson, N., Lounsbury, K.M., van der Vliet, A. J. Biol. Chem. (2008)
- Real-time RT-PCR quantitative assays and postmortem degradation profiles of erythropoietin, vascular endothelial growth factor and hypoxia-inducible factor 1 alpha mRNA transcripts in forensic autopsy materials. Zhao, D., Zhu, B.L., Ishikawa, T., Quan, L., Li, D.R., Maeda, H. Legal medicine (Tokyo, Japan) (2006)
- Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Ravi, R., Mookerjee, B., Bhujwalla, Z.M., Sutter, C.H., Artemov, D., Zeng, Q., Dillehay, L.E., Madan, A., Semenza, G.L., Bedi, A. Genes Dev. (2000)
- Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway. Yoo, Y.G., Oh, S.H., Park, E.S., Cho, H., Lee, N., Park, H., Kim, D.K., Yu, D.Y., Seong, J.K., Lee, M.O. J. Biol. Chem. (2003)
- NADPH-cytochrome P-450 reductase in the plasma membrane modulates the activation of hypoxia-inducible factor 1. Osada, M., Imaoka, S., Sugimoto, T., Hiroi, T., Funae, Y. J. Biol. Chem. (2002)