Gene Review:
HLA-DRA - major histocompatibility complex, class II...
Homo sapiens
Synonyms:
HLA class II histocompatibility antigen, DR alpha chain, HLA-DRA1, MHC class II antigen DRA, MLRW
- Histone deacetylase activity represses gamma interferon-inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation. Osborne, A., Zhang, H., Yang, W.M., Seto, E., Blanck, G. Mol. Cell. Biol. (2001)
- Apoptosis-independent retinoblastoma protein rescue of HLA class II messenger RNA IFN-gamma inducibility in non-small cell lung carcinoma cells. Lack of surface class II expression associated with a specific defect in HLA-DRA induction. Lu, Y., Boss, J.M., Hu, S.X., Xu, H.J., Blanck, G. J. Immunol. (1996)
- Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain. Yun, S., Gustafsson, K., Fabre, J.W. Int. Immunol. (1997)
- HLA-DMB gene and HLA-DRA promoter region polymorphisms in Australian multiple sclerosis patients. Bennetts, B.H., Teutsch, S.M., Buhler, M.M., Heard, R.N., Stewart, G.J. Hum. Immunol. (1999)
- Anomalous expression of the HLA-DR alpha and beta chains in ovarian and other cancers. Rangel, L.B., Agarwal, R., Sherman-Baust, C.A., Mello-Coelho, V., Pizer, E.S., Ji, H., Taub, D.D., Morin, P.J. Cancer Biol. Ther. (2004)
- CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter. Beresford, G.W., Boss, J.M. Nat. Immunol. (2001)
- Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1. Reimold, A.M., Ponath, P.D., Li, Y.S., Hardy, R.R., David, C.S., Strominger, J.L., Glimcher, L.H. J. Exp. Med. (1996)
- Functional roles of the transcription factor Oct-2A and the high mobility group protein I/Y in HLA-DRA gene expression. Abdulkadir, S.A., Krishna, S., Thanos, D., Maniatis, T., Strominger, J.L., Ono, S.J. J. Exp. Med. (1995)
- Control of nucleo-cytoplasmic HLA-DRA mRNA partitioning by interaction of a retention signal with compartmentalized proteins. Del Pozzo, G., Ciullo, M., Autiero, M., Guardiola, J. J. Mol. Biol. (1994)
- Inhibition of major histocompatibility complex class II gene transcription by nitric oxide and antioxidants. Grimm, M., Spiecker, M., De Caterina, R., Shin, W.S., Liao, J.K. J. Biol. Chem. (2002)
- X box-like sequences in the MHC class II region maintain regulatory function. Gomez, J.A., Majumder, P., Nagarajan, U.M., Boss, J.M. J. Immunol. (2005)
- Localization of IFN-gamma receptor in first trimester placenta to trophoblasts but lack of stimulation of HLA-DRA, -DRB, or invariant chain mRNA expression by IFN-gamma. Peyman, J.A., Hammond, G.L. J. Immunol. (1992)
- Description of a polymorphism in the regulatory region of the HLA-DRA gene. Pinet, V., Eliaou, J.F., Clot, J. Hum. Immunol. (1991)
- Tumor HLA-DR expression linked to early intrahepatic recurrence of hepatocellular carcinoma. Matoba, K., Iizuka, N., Gondo, T., Ishihara, T., Yamada-Okabe, H., Tamesa, T., Takemoto, N., Hashimoto, K., Sakamoto, K., Miyamoto, T., Uchimura, S., Hamamoto, Y., Oka, M. Int. J. Cancer (2005)
- HLA-DRA promoter polymorphism and diversity generation within the immune system. Schwiebert, L.M., Hughes, A., Monos, D.S., Ono, S.J. Hum. Genet. (1997)
- Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos. Ono, S.J., Liou, H.C., Davidon, R., Strominger, J.L., Glimcher, L.H. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Lack of IFN-gamma-mediated induction of the class II transactivator (CIITA) through promoter methylation is predominantly found in developmental tumor cell lines. van der Stoep, N., Biesta, P., Quinten, E., van den Elsen, P.J. Int. J. Cancer (2002)
- Tumor necrosis factor alpha response elements in the HLA-DRA promoter: identification of a tumor necrosis factor alpha-induced DNA-protein complex in astrocytes. Panek, R.B., Moses, H., Ting, J.P., Benveniste, E.N. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Methylation state of the human HLA-DRA gene in T-lymphocytes and B-lymphocytes of transgenic mice. Lack of methylation at one 5'-GCGC site is not required for gene expression. Feriotto, G., Pozzi, L., Ciucci, A., Camarda, G., Mischiati, C., D'Agnano, I., Gambari, R., Giacomini, P. Eur. J. Biochem. (1993)
- Oct-1 maintains an intermediate, stable state of HLA-DRA promoter repression in Rb-defective cells: an Oct-1-containing repressosome that prevents NF-Y binding to the HLA-DRA promoter. Osborne, A.R., Zhang, H., Fejer, G., Palubin, K.M., Niesen, M.I., Blanck, G. J. Biol. Chem. (2004)
- Introduction of exogenous class II trans-activator in MHC class II-deficient ABI fibroblasts results in incomplete rescue of MHC class II antigen expression. Peijnenburg, A., Gobin, S.J., van Eggermond, M.C., Godthelp, B.C., van Graafeiland, N., van den Elsen, P.J. J. Immunol. (1997)
- Direct role of NF-kappaB activation in Toll-like receptor-triggered HLA-DRA expression. Lee, K.W., Lee, Y., Kim, D.S., Kwon, H.J. Eur. J. Immunol. (2006)
- Messenger RNA expression of major histocompatibility complex class II genes in whole blood from septic shock patients. Pachot, A., Monneret, G., Brion, A., Venet, F., Bohé, J., Bienvenu, J., Mougin, B., Lepape, A. Crit. Care Med. (2005)
- The X1 box of HLA-G promoter is a target site for RFX and Sp1 factors. Rousseau, P., Paul, P., O'Brien, M., Dausset, J., Carosella, E.D., Moreau, P. Hum. Immunol. (2000)
- Characterization of a major histocompatibility complex class II X-box-binding protein enhancing tat-induced transcription directed by the human immunodeficiency virus type 1 long terminal repeat. Mischiati, C., Feriotto, G., Borgatti, M., Giacomini, P., Gambari, R. J. Virol. (2000)
- Analysis of the human HLA-DRA gene upstream region: evidence for a stem-loop array directed by nuclear factors. Mischiati, C., Feriotto, G., Bianchi, N., Rutigliano, C., Giacomini, P., Gambari, R. Biochimie (1999)
- Serial peripheral blood cytotoxic lymphocyte gene expression measurements for prediction of pancreas transplant rejection. Cashion, A.K., Sabek, O.M., Driscoll, C.J., Gaber, L.W., Gaber, A.O. Transplant. Proc. (2006)