Gene Review:
norpA - no receptor potential A
Drosophila melanogaster
Synonyms:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase, CG3620, CdkA, DIP2, Dmel\CG3620, ...
- The Drosophila dgq gene encodes a G alpha protein that mediates phototransduction. Lee, Y.J., Shah, S., Suzuki, E., Zars, T., O'Day, P.M., Hyde, D.R. Neuron (1994)
- G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates. Strathmann, M., Simon, M.I. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Targeted mutagenesis of the farnesylation site of Drosophila Ggammae disrupts membrane association of the G protein betagamma complex and affects the light sensitivity of the visual system. Schillo, S., Belusic, G., Hartmann, K., Franz, C., Kühl, B., Brenner-Weiss, G., Paulsen, R., Huber, A. J. Biol. Chem. (2004)
- The Drosophila cation channel trpl expressed in insect Sf9 cells is stimulated by agonists of G-protein-coupled receptors. Harteneck, C., Obukhov, A.G., Zobel, A., Kalkbrenner, F., Schultz, G. FEBS Lett. (1995)
- Drosophila acetylcholinesterase: demonstration of a glycoinositol phospholipid anchor and an endogenous proteolytic cleavage. Haas, R., Marshall, T.L., Rosenberry, T.L. Biochemistry (1988)
- Requirement for a phospholipase C in odor response: overlap between olfaction and vision in Drosophila. Riesgo-Escovar, J., Raha, D., Carlson, J.R. Proc. Natl. Acad. Sci. U.S.A. (1995)
- The Drosophila light-activated conductance is composed of the two channels TRP and TRPL. Niemeyer, B.A., Suzuki, E., Scott, K., Jalink, K., Zuker, C.S. Cell (1996)
- Recent insights in phosphatidylinositol signaling. Majerus, P.W., Ross, T.S., Cunningham, T.W., Caldwell, K.K., Jefferson, A.B., Bansal, V.S. Cell (1990)
- Isolation of a putative phospholipase C gene of Drosophila, norpA, and its role in phototransduction. Bloomquist, B.T., Shortridge, R.D., Schneuwly, S., Perdew, M., Montell, C., Steller, H., Rubin, G., Pak, W.L. Cell (1988)
- Genetic and molecular studies of olfaction in Drosophila. Hekmat-Scafe, D.S., Carlson, J.R. Ciba Found. Symp. (1996)
- cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4). Alvarez, R.A., Ghalayini, A.J., Xu, P., Hardcastle, A., Bhattacharya, S., Rao, P.N., Pettenati, M.J., Anderson, R.E., Baehr, W. Genomics (1995)
- Molecular, biochemical, and electrophysiological characterization of Drosophila norpA mutants. Pearn, M.T., Randall, L.L., Shortridge, R.D., Burg, M.G., Pak, W.L. J. Biol. Chem. (1996)
- Insights on trp channels from in vivo studies in Drosophila. Minke, B., Parnas, M. Annu. Rev. Physiol. (2006)
- Two distantly positioned PDZ domains mediate multivalent INAD-phospholipase C interactions essential for G protein-coupled signaling. van Huizen, R., Miller, K., Chen, D.M., Li, Y., Lai, Z.C., Raab, R.W., Stark, W.S., Shortridge, R.D., Li, M. EMBO J. (1998)
- Light-induced pigment granule migration in the retinular cells of Drosophila melanogaster. Comparison of wild type with ERG-defective mutants. Lo, M.V., Pak, W.L. J. Gen. Physiol. (1981)
- Properties of photoreceptor-specific phospholipase C encoded by the norpA gene of Drosophila melanogaster. Schneuwly, S., Burg, M.G., Lending, C., Perdew, M.H., Pak, W.L. J. Biol. Chem. (1991)
- In vivo light-induced and basal phospholipase C activity in Drosophila photoreceptors measured with genetically targeted phosphatidylinositol 4,5-bisphosphate-sensitive ion channels (Kir2.1). Hardie, R.C., Gu, Y., Martin, F., Sweeney, S.T., Raghu, P. J. Biol. Chem. (2004)
- Activation of heterologously expressed Drosophila TRPL channels: Ca2+ is not required and InsP3 is not sufficient. Hardie, R.C., Raghu, P. Cell Calcium (1998)
- Purification, G protein activation, and partial amino acid sequence of a novel phospholipase C from squid photoreceptors. Mitchell, J., Mayeenuddin, L.H. Biochemistry (1998)
- Tissue-specific expression of phospholipase C encoded by the norpA gene of Drosophila melanogaster. Zhu, L., McKay, R.R., Shortridge, R.D. J. Biol. Chem. (1993)
- Evidence for indirect control of phospholipase C (PLC-beta) by retinoids in Drosophila phototransduction. Shim, K., Zavarella, K.M., Thomas, C.F., Shortridge, R.D., Stark, W.S. Mol. Vis. (2001)
- Direct activation of trpl cation channels by G alpha11 subunits. Obukhov, A.G., Harteneck, C., Zobel, A., Harhammer, R., Kalkbrenner, F., Leopoldt, D., Lückhoff, A., Nürnberg, B., Schultz, G. EMBO J. (1996)
- Phosphoinositide-mediated phototransduction in Drosophila photoreceptors: the role of Ca2+ and trp. Hardie, R.C., Minke, B. Cell Calcium (1995)
- Regulation of Drosophila TRPC channels by protein and lipid interactions. Raghu, P. Semin. Cell Dev. Biol. (2006)
- Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA. Kimple, M.E., Siderovski, D.P., Sondek, J. EMBO J. (2001)
- Loss of the phospholipase C gene product induces massive endocytosis of rhodopsin and arrestin in Drosophila photoreceptors. Orem, N.R., Dolph, P.J. Vision Res. (2002)
- InsP3 receptor is essential for growth and differentiation but not for vision in Drosophila. Acharya, J.K., Jalink, K., Hardy, R.W., Hartenstein, V., Zuker, C.S. Neuron (1997)
- The Calliphora rpa mutant lacks the PDZ domain-assembled INAD signalling complex. Huber, A., Belusic, G., Da Silva, N., Bähner, M., Gerdon, G., Draslar, K., Paulsen, R. Eur. J. Neurosci. (2000)
- TRP channels in Drosophila photoreceptors: the lipid connection. Hardie, R.C. Cell Calcium (2003)
- A 49-kilodalton phosphoprotein in the Drosophila photoreceptor is an arrestin homolog. Yamada, T., Takeuchi, Y., Komori, N., Kobayashi, H., Sakai, Y., Hotta, Y., Matsumoto, H. Science (1990)
- Purification, characterization, and partial amino acid sequence of a G protein-activated phospholipase C from squid photoreceptors. Mitchell, J., Gutierrez, J., Northup, J.K. J. Biol. Chem. (1995)
- Rescue of light responses in the Drosophila "null" phospholipase C mutant, norpAP24, by the diacylglycerol kinase mutant, rdgA, and by metabolic inhibition. Hardie, R.C., Martin, F., Chyb, S., Raghu, P. J. Biol. Chem. (2003)
- Substitution of a non-retinal phospholipase C in Drosophila phototransduction. Kim, S., Chen, D.M., Zavarella, K., Fourtner, C.F., Stark, W.S., Shortridge, R.D. Insect Mol. Biol. (2003)
- The roles of PDZ-containing proteins in PLC-beta-mediated signaling. Suh, P.G., Hwang, J.I., Ryu, S.H., Donowitz, M., Kim, J.H. Biochem. Biophys. Res. Commun. (2001)
- Phospholipase C rescues visual defect in norpA mutant of Drosophila melanogaster. McKay, R.R., Chen, D.M., Miller, K., Kim, S., Stark, W.S., Shortridge, R.D. J. Biol. Chem. (1995)
- Characteristics of Drosophila rhodopsin in wild-type and norpA vision transduction mutants. Ostroy, S.E. J. Gen. Physiol. (1978)
- Microphotometric, ultrastructural, and electrophysiological analyses of light-dependent processes on visual receptors in white-eyed wild-type and norpA (no receptor potential) mutant Drosophila. Zinkl, G.M., Maier, L., Studer, K., Sapp, R., Chen, D.M., Stark, W.S. Vis. Neurosci. (1990)