Gene Review:
HMGB2 - high mobility group box 2
Homo sapiens
Synonyms:
HMG-2, HMG2, High mobility group protein 2, High mobility group protein B2
- Recombinant derivatives of the human high-mobility group protein HMGB2 mediate efficient nonviral gene delivery. Sloots, A., Wels, W.S. FEBS J. (2005)
- High mobility group (HMG) non-histone chromosomal proteins HMG1 and HMG2 are significant target antigens of perinuclear anti-neutrophil cytoplasmic antibodies in autoimmune hepatitis. Sobajima, J., Ozaki, S., Uesugi, H., Osakada, F., Inoue, M., Fukuda, Y., Shirakawa, H., Yoshida, M., Rokuhara, A., Imai, H., Kiyosawa, K., Nakao, K. Gut (1999)
- A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivo. Porkka, K., Laakkonen, P., Hoffman, J.A., Bernasconi, M., Ruoslahti, E. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen. Ise, T., Nagatani, G., Imamura, T., Kato, K., Takano, H., Nomoto, M., Izumi, H., Ohmori, H., Okamoto, T., Ohga, T., Uchiumi, T., Kuwano, M., Kohno, K. Cancer Res. (1999)
- Prevalence and characterization of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) directed against HMG1 and HMG2 in ulcerative colitis (UC). Sobajima, J., Ozaki, S., Uesugi, H., Osakada, F., Shirakawa, H., Yoshida, M., Nakao, K. Clin. Exp. Immunol. (1998)
- Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Fan, Z., Beresford, P.J., Oh, D.Y., Zhang, D., Lieberman, J. Cell (2003)
- A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Sinclair, A.H., Berta, P., Palmer, M.S., Hawkins, J.R., Griffiths, B.L., Smith, M.J., Foster, J.W., Frischauf, A.M., Lovell-Badge, R., Goodfellow, P.N. Nature (1990)
- INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. Flury, I., Garza, R., Shearer, A., Rosen, J., Cronin, S., Hampton, R.Y. EMBO J. (2005)
- Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high-mobility-group protein 2-related domains. Wang, Z., Roeder, R.G. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Protein kinase CK2 differentially phosphorylates maize chromosomal high mobility group B (HMGB) proteins modulating their stability and DNA interactions. Stemmer, C., Schwander, A., Bauw, G., Fojan, P., Grasser, K.D. J. Biol. Chem. (2002)
- Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes. Pallier, C., Scaffidi, P., Chopineau-Proust, S., Agresti, A., Nordmann, P., Bianchi, M.E., Marechal, V. Mol. Biol. Cell (2003)
- Involvement of HMGB1 and HMGB2 proteins in exogenous DNA integration reaction into the genome of HeLa S3 cells. Ueda, T., Shirakawa, H., Yoshida, M. Biochim. Biophys. Acta (2002)
- HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Fan, Z., Beresford, P.J., Zhang, D., Lieberman, J. Mol. Cell. Biol. (2002)
- Structure of a gene coding for human HMG2 protein. Shirakawa, H., Yoshida, M. J. Biol. Chem. (1992)
- Antibodies against a peptide sequence located in the linker region of the HMG-1/2 box domains in sera from patients with juvenile rheumatoid arthritis. Jung, F., Neuer, G., Bautz, F.A. Arthritis Rheum. (1997)
- Genome scans and gene expression microarrays converge to identify gene regulatory loci relevant in schizophrenia. Vawter, M.P., Atz, M.E., Rollins, B.L., Cooper-Casey, K.M., Shao, L., Byerley, W.F. Hum. Genet. (2006)
- High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells. Boonyaratanakornkit, V., Melvin, V., Prendergast, P., Altmann, M., Ronfani, L., Bianchi, M.E., Taraseviciene, L., Nordeen, S.K., Allegretto, E.A., Edwards, D.P. Mol. Cell. Biol. (1998)
- Characterization of high mobility group protein binding to cisplatin-damaged DNA. Billings, P.C., Davis, R.J., Engelsberg, B.N., Skov, K.A., Hughes, E.N. Biochem. Biophys. Res. Commun. (1992)
- Differential binding of HMG1, HMG2, and a single HMG box to cisplatin-damaged DNA. Farid, R.S., Bianchi, M.E., Falciola, L., Engelsberg, B.N., Billings, P.C. Toxicol. Appl. Pharmacol. (1996)
- Molecular characterization of Hmg2 gene encoding a 3-hydroxy-methylglutaryl-CoA reductase in rice. Ha, S.H., Lee, S.W., Kim, Y.M., Hwang, Y.S. Mol. Cells (2001)
- Overexpression of high-mobility group box 2 is associated with tumor aggressiveness and prognosis of hepatocellular carcinoma. Kwon, J.H., Kim, J., Park, J.Y., Hong, S.M., Park, C.W., Hong, S.J., Park, S.Y., Choi, Y.J., Do, I.G., Joh, J.W., Kim, D.S., Choi, K.Y. Clin. Cancer Res. (2010)
- Interaction of non-histone chromosomal proteins HMG1 and HMG2 with DNA. Yu, S.S., Li, H.J., Goodwin, G.H., Johns, E.W. Eur. J. Biochem. (1977)
- Identification of the core-histone-binding domains of HMG1 and HMG2. Bernués, J., Espel, E., Querol, E. Biochim. Biophys. Acta (1986)
- HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter. Stros, M., Ozaki, T., Bacikova, A., Kageyama, H., Nakagawara, A. J. Biol. Chem. (2002)
- High-mobility group protein 2 may be involved in the locus control region regulation of the beta-globin gene cluster. Lv, X., Xu, D.D., Liu, D.P., Li, L., Hao, D.L., Liang, C.C. Biochem. Cell Biol. (2002)
- Abundance of mRNAs encoding HMG1/HMG2 class high-mobility-group DNA-binding proteins are differentially regulated in cotyledons of Pharbitis nil. O'Neill, S.D., Zheng, C.C. Plant Mol. Biol. (1998)
- High mobility group B proteins facilitate strong estrogen receptor binding to classical and half-site estrogen response elements and relax binding selectivity. Das, D., Peterson, R.C., Scovell, W.M. Mol. Endocrinol. (2004)
- The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition. Zayed, H., Izsvák, Z., Khare, D., Heinemann, U., Ivics, Z. Nucleic Acids Res. (2003)
- Genomic analysis of facioscapulohumeral muscular dystrophy. Clapp, J., Bolland, D.J., Hewitt, J.E. Briefings in functional genomics & proteomics. (2003)
- Alleviation of histone H1-mediated transcriptional repression and chromatin compaction by the acidic activation region in chromosomal protein HMG-14. Ding, H.F., Bustin, M., Hansen, U. Mol. Cell. Biol. (1997)
- High mobility group protein 1 (HMGB1) quantified by ELISA with a monoclonal antibody that does not cross-react with HMGB2. Yamada, S., Inoue, K., Yakabe, K., Imaizumi, H., Maruyama, I. Clin. Chem. (2003)
- Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks. Nagaki, S., Yamamoto, M., Yumoto, Y., Shirakawa, H., Yoshida, M., Teraoka, H. Biochem. Biophys. Res. Commun. (1998)