Gene Review:
ONECUT1 - one cut homeobox 1
Homo sapiens
Synonyms:
HNF-6, HNF6, HNF6A, Hepatocyte nuclear factor 6, One cut domain family member 1, ...
- Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding. Rausa, F.M., Tan, Y., Costa, R.H. Mol. Cell. Biol. (2003)
- Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion. Møller, A.M., Ek, J., Durviaux, S.M., Urhammer, S.A., Clausen, J.O., Eiberg, H., Hansen, T., Rousseau, G.G., Lemaigre, F.P., Pedersen, O. Diabetologia (1999)
- Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Jacquemin, P., Durviaux, S.M., Jensen, J., Godfraind, C., Gradwohl, G., Guillemot, F., Madsen, O.D., Carmeliet, P., Dewerchin, M., Collen, D., Rousseau, G.G., Lemaigre, F.P. Mol. Cell. Biol. (2000)
- Variability of the insulin receptor substrate-1, hepatocyte nuclear factor-1alpha (HNF-1alpha), HNF-4alpha, and HNF-6 genes and size at birth in a population-based sample of young Danish subjects. Rasmussen, S.K., Urhammer, S.A., Hansen, T., Almind, K., Møller, A.M., Borch-Johnsen, K., Pedersen, O. J. Clin. Endocrinol. Metab. (2000)
- Antiglucocorticoid activity of hepatocyte nuclear factor-6. Pierreux, C.E., Stafford, J., Demonte, D., Scott, D.K., Vandenhaute, J., O'Brien, R.M., Granner, D.K., Rousseau, G.G., Lemaigre, F.P. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Mitogen-Activated Protein Kinase-Mediated Disruption of Enhancer-Promoter Communication Inhibits Hepatocyte Nuclear Factor 4{alpha} Expression. Hatzis, P., Kyrmizi, I., Talianidis, I. Mol. Cell. Biol. (2006)
- Threshold levels of hepatocyte nuclear factor 6 (HNF-6) acting in synergy with HNF-4 and PGC-1alpha are required for time-specific gene expression during liver development. Beaudry, J.B., Pierreux, C.E., Hayhurst, G.P., Plumb-Rudewiez, N., Weiss, M.C., Rousseau, G.G., Lemaigre, F.P. Mol. Cell. Biol. (2006)
- C/EBPalpha and HNF6 protein complex formation stimulates HNF6-dependent transcription by CBP coactivator recruitment in HepG2 cells. Yoshida, Y., Hughes, D.E., Rausa, F.M., Kim, I.M., Tan, Y., Darlington, G.J., Costa, R.H. Hepatology (2006)
- Stability of the hepatocyte nuclear factor 6 transcription factor requires acetylation by the CREB-binding protein coactivator. Rausa, F.M., Hughes, D.E., Costa, R.H. J. Biol. Chem. (2004)
- OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6. Jacquemin, P., Lannoy, V.J., Rousseau, G.G., Lemaigre, F.P. J. Biol. Chem. (1999)
- Temporal Regulation of Enhancer Function in Intestinal Epithelium: A ROLE FOR ONECUT FACTORS. Maier, E.A., Dusing, M.R., Wiginton, D.A. J. Biol. Chem. (2006)
- DNA recognition mechanism of the ONECUT homeodomain of transcription factor HNF-6. Iyaguchi, D., Yao, M., Watanabe, N., Nishihira, J., Tanaka, I. Structure (2007)
- Transcriptional stimulation by hepatocyte nuclear factor-6. Target-specific recruitment of either CREB-binding protein (CBP) or p300/CBP-associated factor (p/CAF). Lannoy, V.J., Rodolosse, A., Pierreux, C.E., Rousseau, G.G., Lemaigre, F.P. J. Biol. Chem. (2000)
- Hepatocyte nuclear factor-6 stimulates transcription of the alpha-fetoprotein gene and synergizes with the retinoic-acid-receptor-related orphan receptor alpha-4. Nacer-Cherif, H., Bois-Joyeux, B., Rousseau, G.G., Lemaigre, F.P., Danan, J.L. Biochem. J. (2003)
- Maintaining HNF6 expression prevents AdHNF3beta-mediated decrease in hepatic levels of Glut-2 and glycogen. Tan, Y., Adami, G., Costa, R.H. Hepatology (2002)
- Type I protein C deficiency caused by disruption of a hepatocyte nuclear factor (HNF)-6/HNF-1 binding site in the human protein C gene promoter. Spek, C.A., Lannoy, V.J., Lemaigre, F.P., Rousseau, G.G., Bertina, R.M., Reitsma, P.H. J. Biol. Chem. (1998)
- The role of hepatic nuclear factor 1 alpha and PDX-1 in transcriptional regulation of the pdx-1 gene. Gerrish, K., Cissell, M.A., Stein, R. J. Biol. Chem. (2001)
- Unique distance- and DNA-turn-dependent interactions in the human protein C gene promoter confer submaximal transcriptional activity. Spek, C.A., Bertina, R.M., Reitsma, P.H. Biochem. J. (1999)
- Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4alpha and HNF1beta in a pancreatic beta-cell line. Thomas, H., Senkel, S., Erdmann, S., Arndt, T., Turan, G., Klein-Hitpass, L., Ryffel, G.U. Nucleic Acids Res. (2004)
- Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6. Vaisse, C., Kim, J., Espinosa, R., Le Beau, M.M., Stoffel, M. Diabetes (1997)
- The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression. Samadani, U., Costa, R.H. Mol. Cell. Biol. (1996)
- In vivo transfection of rat liver discloses binding sites conveying GH-dependent and female-specific gene expression. Gardmo, C., Mode, A. J. Mol. Endocrinol. (2006)