Gene Review:
HNRNPK - heterogeneous nuclear ribonucleoprotein K
Homo sapiens
Synonyms:
CSBP, HNRPK, Heterogeneous nuclear ribonucleoprotein K, TUNP, Transformation up-regulated nuclear protein, ...
- A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation. Notari, M., Neviani, P., Santhanam, R., Blaser, B.W., Chang, J.S., Galietta, A., Willis, A.E., Roy, D.C., Caligiuri, M.A., Marcucci, G., Perrotti, D. Blood (2006)
- Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex. Tripodis, N., Mason, R., Humphray, S.J., Davies, A.F., Herberg, J.A., Trowsdale, J., Nizetic, D., Senger, G., Ragoussis, J. Genome Res. (1998)
- Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K. Hsieh, T.Y., Matsumoto, M., Chou, H.C., Schneider, R., Hwang, S.B., Lee, A.S., Lai, M.M. J. Biol. Chem. (1998)
- Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation. Miau, L.H., Chang, C.J., Shen, B.J., Tsai, W.H., Lee, S.C. J. Biol. Chem. (1998)
- Editing of hnRNP K protein mRNA in colorectal adenocarcinoma and surrounding mucosa. Klimek-Tomczak, K., Mikula, M., Dzwonek, A., Paziewska, A., Karczmarski, J., Hennig, E., Bujnicki, J.M., Bragoszewski, P., Denisenko, O., Bomsztyk, K., Ostrowski, J. Br. J. Cancer (2006)
- hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. Moumen, A., Masterson, P., O'Connor, M.J., Jackson, S.P. Cell (2005)
- mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end. Ostareck, D.H., Ostareck-Lederer, A., Wilm, M., Thiele, B.J., Mann, M., Hentze, M.W. Cell (1997)
- Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system. Buckanovich, R.J., Posner, J.B., Darnell, R.B. Neuron (1993)
- c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs. Ostareck-Lederer, A., Ostareck, D.H., Cans, C., Neubauer, G., Bomsztyk, K., Superti-Furga, G., Hentze, M.W. Mol. Cell. Biol. (2002)
- Asymmetric Arginine Dimethylation of Heterogeneous Nuclear Ribonucleoprotein K by Protein-arginine Methyltransferase 1 Inhibits Its Interaction with c-Src. Ostareck-Lederer, A., Ostareck, D.H., Rucknagel, K.P., Schierhorn, A., Moritz, B., Huttelmaier, S., Flach, N., Handoko, L., Wahle, E. J. Biol. Chem. (2006)
- An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K. Chen, H.C., Lin, W.C., Tsay, Y.G., Lee, S.C., Chang, C.J. J. Biol. Chem. (2002)
- Functional interaction of Sam68 and heterogeneous nuclear ribonucleoprotein K. Yang, J.P., Reddy, T.R., Truong, K.T., Suhasini, M., Wong-Staal, F. Oncogene (2002)
- Heterogeneous nuclear ribonucleoprotein K protein associates with multiple mitochondrial transcripts within the organelle. Ostrowski, J., Wyrwicz, L., Rychlewski, L., Bomsztyk, K. J. Biol. Chem. (2002)
- Identification, molecular cloning, expression and chromosome mapping of a family of transformation upregulated hnRNP-K proteins derived by alternative splicing. Dejgaard, K., Leffers, H., Rasmussen, H.H., Madsen, P., Kruse, T.A., Gesser, B., Nielsen, H., Celis, J.E. J. Mol. Biol. (1994)
- The DICE-binding activity of KH domain 3 of hnRNP K is affected by c-Src-mediated tyrosine phosphorylation. Messias, A.C., Harnisch, C., Ostareck-Lederer, A., Sattler, M., Ostareck, D.H. J. Mol. Biol. (2006)
- Anti-IgM induces up-regulation and tyrosine-phosphorylation of heterogeneous nuclear ribonucleoprotein K proteins (hnRNP K) in a Ramos B cell line. Jeon, H.K., Ahn, J.H., Choe, J., Park, J.H., Lee, T.H. Immunol. Lett. (2005)
- Identification of two proteins that bind to a pyrimidine-rich sequence in the 3'-untranslated region of GAP-43 mRNA. Irwin, N., Baekelandt, V., Goritchenko, L., Benowitz, L.I. Nucleic Acids Res. (1997)
- Heterogeneous nuclear ribonucleoprotein k modulates angiotensinogen gene expression in kidney cells. Wei, C.C., Zhang, S.L., Chen, Y.W., Guo, D.F., Ingelfinger, J.R., Bomsztyk, K., Chan, J.S. J. Biol. Chem. (2006)
- Epidermal growth factor increases the interaction between nucleolin and heterogeneous nuclear ribonucleoprotein K/poly(C) binding protein 1 complex to regulate the gastrin mRNA turnover. Lee, P.T., Liao, P.C., Chang, W.C., Tseng, J.T. Mol. Biol. Cell (2007)
- hnRNP-K and Pur(alpha) act together to repress the transcriptional activity of the CD43 gene promoter. Da Silva, N., Bharti, A., Shelley, C.S. Blood (2002)
- PDGF regulates the actin cytoskeleton through hnRNP-K-mediated activation of the ubiquitin E(3)-ligase MIR. Nagano, K., Bornhauser, B.C., Warnasuriya, G., Entwistle, A., Cramer, R., Lindholm, D., Naaby-Hansen, S. EMBO J. (2006)
- Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein. Shnyreva, M., Schullery, D.S., Suzuki, H., Higaki, Y., Bomsztyk, K. J. Biol. Chem. (2000)
- Translational inhibition in vitro of human papillomavirus type 16 L2 mRNA mediated through interaction with heterogenous ribonucleoprotein K and poly(rC)-binding proteins 1 and 2. Collier, B., Goobar-Larsson, L., Sokolowski, M., Schwartz, S. J. Biol. Chem. (1998)
- Nuclear shift of hnRNP K protein in neoplasms and other states of enhanced cell proliferation. Ostrowski, J., Bomsztyk, K. Br. J. Cancer (2003)
- Crystallization, microPIXE and preliminary crystallographic analysis of the complex between the third KH domain of hnRNP K and single-stranded DNA. Backe, P.H., Ravelli, R.B., Garman, E., Cusack, S. Acta Crystallogr. D Biol. Crystallogr. (2004)
- hnRNP K binds a core polypyrimidine element in the eukaryotic translation initiation factor 4E (eIF4E) promoter, and its regulation of eIF4E contributes to neoplastic transformation. Lynch, M., Chen, L., Ravitz, M.J., Mehtani, S., Korenblat, K., Pazin, M.J., Schmidt, E.V. Mol. Cell. Biol. (2005)