Gene Review:
Lig4 - ligase IV, DNA, ATP-dependent
Mus musculus
Synonyms:
5830471N16Rik, DNA ligase 4, DNA ligase IV, tiny
- DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Frank, K.M., Sharpless, N.E., Gao, Y., Sekiguchi, J.M., Ferguson, D.O., Zhu, C., Manis, J.P., Horner, J., DePinho, R.A., Alt, F.W. Mol. Cell (2000)
- DNA ligase IV suppresses medulloblastoma formation. Lee, Y., McKinnon, P.J. Cancer Res. (2002)
- Evidence that stable retroviral transduction and cell survival following DNA integration depend on components of the nonhomologous end joining repair pathway. Daniel, R., Greger, J.G., Katz, R.A., Taganov, K.D., Wu, X., Kappes, J.C., Skalka, A.M. J. Virol. (2004)
- Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Frank, K.M., Sekiguchi, J.M., Seidl, K.J., Swat, W., Rathbun, G.A., Cheng, H.L., Davidson, L., Kangaloo, L., Alt, F.W. Nature (1998)
- Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability. Mills, K.D., Ferguson, D.O., Essers, J., Eckersdorff, M., Kanaar, R., Alt, F.W. Genes Dev. (2004)
- Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm. Lee, Y., Barnes, D.E., Lindahl, T., McKinnon, P.J. Genes Dev. (2000)
- A biochemically defined system for mammalian nonhomologous DNA end joining. Ma, Y., Lu, H., Tippin, B., Goodman, M.F., Shimazaki, N., Koiwai, O., Hsieh, C.L., Schwarz, K., Lieber, M.R. Mol. Cell (2004)
- Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. Sekiguchi, J., Ferguson, D.O., Chen, H.T., Yang, E.M., Earle, J., Frank, K., Whitlow, S., Gu, Y., Xu, Y., Nussenzweig, A., Alt, F.W. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Gu, Y., Sekiguchi, J., Gao, Y., Dikkes, P., Frank, K., Ferguson, D., Hasty, P., Chun, J., Alt, F.W. Proc. Natl. Acad. Sci. U.S.A. (2000)
- The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Ferguson, D.O., Sekiguchi, J.M., Chang, S., Frank, K.M., Gao, Y., DePinho, R.A., Alt, F.W. Proc. Natl. Acad. Sci. U.S.A. (2000)
- DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Celli, G.B., de Lange, T. Nat. Cell Biol. (2005)
- Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice. Barnes, D.E., Stamp, G., Rosewell, I., Denzel, A., Lindahl, T. Curr. Biol. (1998)
- Identification of a mutated DNA ligase IV gene in the X-ray-hypersensitive mutant SX10 of mouse FM3A cells. Sado, K., Ayusawa, D., Enomoto, A., Suganuma, T., Oshimura, M., Sato, K., Koyama, H. J. Biol. Chem. (2001)
- Crystal structure of the Xrcc4 DNA repair protein and implications for end joining. Junop, M.S., Modesti, M., Guarné, A., Ghirlando, R., Gellert, M., Yang, W. EMBO J. (2000)
- Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Orii, K.E., Lee, Y., Kondo, N., McKinnon, P.J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts. Karanjawala, Z.E., Grawunder, U., Hsieh, C.L., Lieber, M.R. Curr. Biol. (1999)
- p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc. Gladdy, R.A., Nutter, L.M., Kunath, T., Danska, J.S., Guidos, C.J. Mol. Cancer Res. (2006)