Gene Review:
ACACB - acetyl-CoA carboxylase beta
Homo sapiens
Synonyms:
ACC-beta, ACC2, ACCB, Acetyl-CoA carboxylase 2, HACC275
Wojtaszewski,
Mourtzakis,
Hillig,
Saltin,
Pilegaard,
Rosa,
Manco,
Vega,
Greco,
Castagneto,
Vidal,
Mingrone,
Nielsen,
Wojtaszewski,
Haller,
Hardie,
Kemp,
Richter,
Vissing,
Steinberg,
Smith,
Van Denderen,
Chen,
Murthy,
Campbell,
Heigenhauser,
Dyck,
Kemp,
Nakamuta,
Kohjima,
Morizono,
Kotoh,
Yoshimoto,
Miyagi,
Enjoji,
Birk,
Wojtaszewski,
Schrauwen,
van Aggel-Leijssen,
Hul,
Wagenmakers,
Vidal,
Saris,
van Baak,
Mensink,
Blaak,
Vidal,
De Bruin,
Glatz,
Saris,
Sakamoto,
Zarrinpashneh,
Budas,
Pouleur,
Dutta,
Prescott,
Vanoverschelde,
Ashworth,
Jovanovic,
Alessi,
Bertrand,
- Cloning of human acetyl-CoA carboxylase-beta and its unique features. Ha, J., Lee, J.K., Kim, K.S., Witters, L.A., Kim, K.H. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Expression of genes regulating Malonyl-CoA in human skeletal muscle. Pender, C., Trentadue, A.R., Pories, W.J., Dohm, G.L., Houmard, J.A., Youngren, J.F. J. Cell. Biochem. (2006)
- Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPK{alpha}2 but not AMPK{alpha}1. Sakamoto, K., Zarrinpashneh, E., Budas, G.R., Pouleur, A.C., Dutta, A., Prescott, A.R., Vanoverschelde, J.L., Ashworth, A., Jovanovic, A., Alessi, D.R., Bertrand, L. Am. J. Physiol. Endocrinol. Metab. (2006)
- Effect of exercise intensity and hypoxia on skeletal muscle AMPK signaling and substrate metabolism in humans. Wadley, G.D., Lee-Young, R.S., Canny, B.J., Wasuntarawat, C., Chen, Z.P., Hargreaves, M., Kemp, B.E., McConell, G.K. Am. J. Physiol. Endocrinol. Metab. (2006)
- Identification of human acetyl-CoA carboxylase isozymes in tissue and in breast cancer cells. Witters, L.A., Widmer, J., King, A.N., Fassihi, K., Kuhajda, F. Int. J. Biochem. (1994)
- Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1{alpha}. Cha, S.H., Rodgers, J.T., Puigserver, P., Chohnan, S., Lane, M.D. Proc. Natl. Acad. Sci. U.S.A. (2006)
- The subcellular localization of acetyl-CoA carboxylase 2. Abu-Elheiga, L., Brinkley, W.R., Zhong, L., Chirala, S.S., Woldegiorgis, G., Wakil, S.J. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Assignment of acetyl-CoA carboxylase-beta (ACACB) to human chromosome band 12q24.1 by in situ hybridization. Ullrich, C.K., Widmer, J., Park, J.P., Mohandas, T.K., Witters, L.A. Cytogenet. Cell Genet. (1997)
- Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver. Oh, S.Y., Park, S.K., Kim, J.W., Ahn, Y.H., Park, S.W., Kim, K.S. J. Biol. Chem. (2003)
- Identification of a second human acetyl-CoA carboxylase gene. Widmer, J., Fassihi, K.S., Schlichter, S.C., Wheeler, K.S., Crute, B.E., King, N., Nutile-McMenemy, N., Noll, W.W., Daniel, S., Ha, J., Kim, K.H., Witters, L.A. Biochem. J. (1996)
- Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics. Chen, M.B., McAinch, A.J., Macaulay, S.L., Castelli, L.A., O'brien, P.E., Dixon, J.B., Cameron-Smith, D., Kemp, B.E., Steinberg, G.R. J. Clin. Endocrinol. Metab. (2005)
- Upstream stimulatory factor 1 transactivates the human gene promoter of the cardiac isoform of acetyl-CoA carboxylase. Makaula, S., Adam, T., Essop, M.F. Arch. Biochem. Biophys. (2006)
- Roles of acetyl-CoA carboxylase beta in muscle cell differentiation and in mitochondrial fatty acid oxidation. Lee, J.K., Kim, K.H. Biochem. Biophys. Res. Commun. (1999)
- Expression, purification, and characterization of human and rat acetyl cfenzyme A carboxylase (ACC) isozymes. Cheng, D., Chu, C.H., Chen, L., Feder, J.N., Mintier, G.A., Wu, Y., Cook, J.W., Harpel, M.R., Locke, G.A., An, Y., Tamura, J.K. Protein Expr. Purif. (2007)
- Decreased muscle acetyl-coenzyme A carboxylase 2 mRNA and insulin resistance in formerly obese subjects. Rosa, G., Manco, M., Vega, N., Greco, A.V., Castagneto, M., Vidal, H., Mingrone, G. Obes. Res. (2003)
- Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. Musi, N., Hirshman, M.F., Nygren, J., Svanfeldt, M., Bavenholm, P., Rooyackers, O., Zhou, G., Williamson, J.M., Ljunqvist, O., Efendic, S., Moller, D.E., Thorell, A., Goodyear, L.J. Diabetes (2002)
- AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese females. Steinberg, G.R., Smith, A.C., Van Denderen, B.J., Chen, Z., Murthy, S., Campbell, D.J., Heigenhauser, G.J., Dyck, D.J., Kemp, B.E. J. Clin. Endocrinol. Metab. (2004)
- Role of 5'AMP-activated protein kinase in glycogen synthase activity and glucose utilization: insights from patients with McArdle's disease. Nielsen, J.N., Wojtaszewski, J.F., Haller, R.G., Hardie, D.G., Kemp, B.E., Richter, E.A., Vissing, J. J. Physiol. (Lond.) (2002)
- Cloning of human acetyl-CoA carboxylase beta promoter and its regulation by muscle regulatory factors. Lee, J.J., Moon, Y.A., Ha, J.H., Yoon, D.J., Ahn, Y.H., Kim, K.S. J. Biol. Chem. (2001)
- Evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. Nakamuta, M., Kohjima, M., Morizono, S., Kotoh, K., Yoshimoto, T., Miyagi, I., Enjoji, M. Int. J. Mol. Med. (2005)
- Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exercise. Wojtaszewski, J.F., Mourtzakis, M., Hillig, T., Saltin, B., Pilegaard, H. Biochem. Biophys. Res. Commun. (2002)
- The effect of a 3-month low-intensity endurance training program on fat oxidation and acetyl-CoA carboxylase-2 expression. Schrauwen, P., van Aggel-Leijssen, D.P., Hul, G., Wagenmakers, A.J., Vidal, H., Saris, W.H., van Baak, M.A. Diabetes (2002)
- Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms. Abu-Elheiga, L., Almarza-Ortega, D.B., Baldini, A., Wakil, S.J. J. Biol. Chem. (1997)
- Predominant {alpha}2/{beta}2/{gamma}3 AMPK activation during exercise in human skeletal muscle. Birk, J.B., Wojtaszewski, J.F. J. Physiol. (Lond.) (2006)
- Progressive increase in human skeletal muscle AMPKalpha2 activity and ACC phosphorylation during exercise. Stephens, T.J., Chen, Z.P., Canny, B.J., Michell, B.J., Kemp, B.E., McConell, G.K. Am. J. Physiol. Endocrinol. Metab. (2002)
- Lifestyle changes and lipid metabolism gene expression and protein content in skeletal muscle of subjects with impaired glucose tolerance. Mensink, M., Blaak, E.E., Vidal, H., De Bruin, T.W., Glatz, J.F., Saris, W.H. Diabetologia (2003)