High impact information on lic

• Our phenotypic data argue for a role of lic in a post-transcriptional regulation of the grk gene [1].
• In lic mutant egg chambers, oskar mRNA posterior localization is not properly maintained, resulting in anteroposterior patterning defects in the embryo [1].
• Furthermore, lic loss-of-function in the germ line leads to reduced EGF receptor activity in dorsal follicle cells and ventralization of the egg shell [1].
• Furthermore, genes that encode two novel Drosophila MAP kinase kinases, D-MKK3 and D-MKK4, were identified [2].
• One of the responses evoked by these stimuli is the initiation of a kinase cascade that leads to the phosphorylation of p38 mitogen-activated protein (MAP) kinase on Thr and Tyr within the motif Thr-Gly-Tyr, which is located within subdomain VIII [2].

Biological context of lic

• Activation of p38 is mediated through phosphorylation by upstream MAPKK, which in turn is activated by MAPKKK [3].
• A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression [2].
• The role of the p38 pathway in generation of axial polarity during oogenesis has been inferred from phenotypic analysis of mutations in the Drosophila homolog of DMKK3 [4].

Anatomical context of lic

• p38 MAPKs are a conserved subfamily of MAPKs involved in the response to stress found in eukaryotic cells from yeast to mammals [5].

Analytical, diagnostic and therapeutic context of lic

• Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinase [6].

References