The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.
wikigene or wiki gene protein drug chemical gene disease author authorship tracking evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Gene: NFAT  -  NFAT

Drosophila melanogaster

Synonyms: CG11172, dNFAT, Drosophila TonEBP, EP1335, MESR1, Misexpression Suppressor of Ras 1, NFAT5, NF-AT5, Rel domain protein
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text.

Ideally this entry shall become one comprehensive and continuous article. Bulleted lists, for instance, were only used because it is impossible to automatically integrate independent facts into a continuous text.

Much of the current information on this page has been automatically compiled from Pubmed.

This precompiled information serves as a substrate and matrix to embed your contributions, but it is by no means the final word - Homo sapiens can do much better!

WikiGenes is a non-profit and open access community project.

 

 

High impact information on NFAT

  • We present evidence that the DNA-binding activity of the dl protein is mediated by the region of homology (the rel domain) conserved in the rel and NF-kappa B proteins [1].
  • The rel family of proteins can be defined as a group of proteins that share sequence homology over a 300 amino acid region termed the rel domain [2].
  • In an effort to identify additional components that influence Rel-domain gene function we have conducted a search for immunodeficiency mutants in Drosophila [3].
  • Drosophila immunity and embryogenesis appear to be linked by an evolutionarily ancient signalling pathway, which includes the Rel-domain transcription factors Dif and dorsal, respectively, as well as a common inhibitor, cactus [3].
  • The NFAT gene encodes the only homolog in Drosophila of the five human Nuclear Factors of Activated T-cells, NFAT1-5 [4].
 

Biological context of NFAT

  • Here we have used a genome-wide RNA interference (RNAi) screen in Drosophila to identify additional regulators of the signalling pathway leading from Ca2+-calcineurin to NFAT [5].
  • Here we identify the genetic defect in these patients, using a combination of two unbiased genome-wide approaches: a modified linkage analysis with single-nucleotide polymorphism arrays, and a Drosophila RNA interference screen designed to identify regulators of store-operated Ca2+ entry and NFAT nuclear import [6].

References

  1. The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in Drosophila. Ip, Y.T., Kraut, R., Levine, M., Rushlow, C.A. Cell (1991)
  2. The rel family of proteins. Rushlow, C., Warrior, R. Bioessays (1992)
  3. Characterization of an immunodeficiency mutant in Drosophila. Corbo, J.C., Levine, M. Mech. Dev. (1996)
  4. The Drosophila NFAT homolog is involved in salt stress tolerance. Keyser, P., Borge-Renberg, K., Hultmark, D. Insect Biochem. Mol. Biol. (2007)
  5. A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Gwack, Y., Sharma, S., Nardone, J., Tanasa, B., Iuga, A., Srikanth, S., Okamura, H., Bolton, D., Feske, S., Hogan, P.G., Rao, A. Nature (2006)
  6. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Feske, S., Gwack, Y., Prakriya, M., Srikanth, S., Puppel, S.H., Tanasa, B., Hogan, P.G., Lewis, R.S., Daly, M., Rao, A. Nature (2006)
 
 
 
 
 
 
 
[search][advanced]

Editor

Links

Table of contents