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Gene Review

top2a  -  topoisomerase (DNA) II alpha

Danio rerio

Synonyms: SO:0000704, fc08c07, wu:fc08c07
 
 
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High impact information on top2a

  • By developing a methodology to perform PH on adult zebrafish, we found that liver regeneration inuhrf1(+/-) adult animals is impaired.uhrf1 transcript levels dramatically increase after PH in both mice, and zebrafish and top2a is not up-regulated in uhrf1(+/-) livers after PH [1].
 

Biological context of top2a

  • We identified the uhrf1 gene, a cell cycle regulator and transcriptional activator of top2a expression, as required for hepatic outgrowth and embryonic survival [1].

References

  1. Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1. Sadler, K.C., Krahn, K.N., Gaur, N.A., Ukomadu, C. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
 
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