Gene Review:
APC - adenomatous polyposis coli
Homo sapiens
Synonyms:
Adenomatous polyposis coli protein, BTPS2, DP2, DP2.5, DP3, ...
Weijenberg,
Steinbach,
Arvidsson,
Poulsom,
Fagman,
García de Herreros,
Osin,
Izatt,
Jugurnauth,
van Deventer,
Su,
Locke,
Bleuming,
Nilsson,
El-Bahrawy,
Kote-Jarai,
Schepman,
Rowan,
Bancroft,
Gaffield,
Keller,
Qi,
Miravet,
Saritas,
Roemen,
Gui,
Nerurkar,
Brabant,
de Goeij,
Pichert,
Tomlinson,
Piedra,
Roberts,
Eeles,
Alison,
Hardwick,
Duñach,
van den Brandt,
Offerhaus,
Yao,
Helmbrecht,
Bullock,
Caspers,
de Bruïne,
Martinsson,
Barnes,
Ristimäki,
Musler,
Peppelenbosch,
Drillenburg,
Larsson,
Tomlinson,
Poulsom,
Keller,
Wark,
van den Brink,
Lynch,
Nordling,
Giardiello,
Nielsen,
Offerhaus,
Roura,
Lüchtenborg,
van Muijen,
Martínez,
Meuller,
- The molecular basis of Turcot's syndrome. Hamilton, S.R., Liu, B., Parsons, R.E., Papadopoulos, N., Jen, J., Powell, S.M., Krush, A.J., Berk, T., Cohen, Z., Tetu, B. N. Engl. J. Med. (1995)
- Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. van den Brink, G.R., Bleuming, S.A., Hardwick, J.C., Schepman, B.L., Offerhaus, G.J., Keller, J.J., Nielsen, C., Gaffield, W., van Deventer, S.J., Roberts, D.J., Peppelenbosch, M.P. Nat. Genet. (2004)
- Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Tetsu, O., McCormick, F. Nature (1999)
- Caspase cleavage of the APC tumor suppressor and release of an amino-terminal domain is required for the transcription-independent function of APC in apoptosis. Qian, J., Steigerwald, K., Combs, K.A., Barton, M.C., Groden, J. Oncogene (2007)
- Loss of heterozygosity at the BRCA1 and BRCA2 loci detected in ductal lavage fluid from BRCA gene mutation carriers and controls. Locke, I., Kote-Jarai, Z., Bancroft, E., Bullock, S., Jugurnauth, S., Osin, P., Nerurkar, A., Izatt, L., Pichert, G., Gui, G.P., Eeles, R.A. Cancer Epidemiol. Biomarkers Prev. (2006)
- Balance between endoscopic and genetic information in the choice of ileorectal anastomosis for familial adenomatous polyposis. Valanzano, R., Ficari, F., Curia, M.C., Aceto, G., Veschi, S., Cama, A., Battista, P., Tonelli, F. Journal of surgical oncology (2007)
- Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth. Lasorella, A., Stegmüller, J., Guardavaccaro, D., Liu, G., Carro, M.S., Rothschild, G., de la Torre-Ubieta, L., Pagano, M., Bonni, A., Iavarone, A. Nature (2006)
- MHC multimerization, antigen expression and the induction of APC amnesia in the developing immune response. Lake, R.A., Robinson, B.W., Hayball, J.D. Immunol. Cell Biol. (1999)
- The cardiovascular toxicity of selective and nonselective cyclooxygenase inhibitors: comparisons, contrasts, and aspirin confounding. Konstantinopoulos, P.A., Lehmann, D.F. Journal of clinical pharmacology. (2005)
- X-linked lymphoproliferative disease: a progressive immunodeficiency. Morra, M., Howie, D., Grande, M.S., Sayos, J., Wang, N., Wu, C., Engel, P., Terhorst, C. Annu. Rev. Immunol. (2001)
- Antigen-presenting function of the macrophage. Unanue, E.R. Annu. Rev. Immunol. (1984)
- The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1. Eldridge, A.G., Loktev, A.V., Hansen, D.V., Verschuren, E.W., Reimann, J.D., Jackson, P.K. Cell (2006)
- The ubiquitin-proteasome pathway and serine kinase activity modulate adenomatous polyposis coli protein-mediated regulation of beta-catenin-lymphocyte enhancer-binding factor signaling. Easwaran, V., Song, V., Polakis, P., Byers, S. J. Biol. Chem. (1999)
- Up-regulation of CYP26A1 in adenomatous polyposis coli-deficient vertebrates via a WNT-dependent mechanism: implications for intestinal cell differentiation and colon tumor development. Shelton, D.N., Sandoval, I.T., Eisinger, A., Chidester, S., Ratnayake, A., Ireland, C.M., Jones, D.A. Cancer Res. (2006)
- Molecular analysis of sulindac-resistant adenomas in familial adenomatous polyposis. Keller, J.J., Offerhaus, G.J., Drillenburg, P., Caspers, E., Musler, A., Ristimäki, A., Giardiello, F.M. Clin. Cancer Res. (2001)
- Nitric oxide synthase 2 mRNA expression in relation to p53 and adenomatous polyposis coli mutations in primary colorectal adenocarcinomas. Fransén, K., Dimberg, J., Osterström, A., Olsson, A., Söderkvist, P., Sirsjö, A. Surgery (2002)
- Progression of familial adenomatous polyposis (FAP) colonic cells after transfer of the src or polyoma middle T oncogenes: cooperation between src and HGF/Met in invasion. Empereur, S., Djelloul, S., Di Gioia, Y., Bruyneel, E., Mareel, M., Van Hengel, J., Van Roy, F., Comoglio, P., Courtneidge, S., Paraskeva, C., Chastre, E., Gespach, C. Br. J. Cancer (1997)
- Identification and characterization of the familial adenomatous polyposis coli gene. Groden, J., Thliveris, A., Samowitz, W., Carlson, M., Gelbert, L., Albertsen, H., Joslyn, G., Stevens, J., Spirio, L., Robertson, M. Cell (1991)
- Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Morin, P.J., Sparks, A.B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., Kinzler, K.W. Science (1997)
- Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex. Xing, Y., Clements, W.K., Kimelman, D., Xu, W. Genes Dev. (2003)
- Concordance of genetic alterations in poorly differentiated colorectal neuroendocrine carcinomas and associated adenocarcinomas. Vortmeyer, A.O., Lubensky, I.A., Merino, M.J., Wang, C.Y., Pham, T., Furth, E.E., Zhuang, Z. J. Natl. Cancer Inst. (1997)
- Identification of a link between the tumour suppressor APC and the kinesin superfamily. Jimbo, T., Kawasaki, Y., Koyama, R., Sato, R., Takada, S., Haraguchi, K., Akiyama, T. Nat. Cell Biol. (2002)
- A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Kaplan, K.B., Burds, A.A., Swedlow, J.R., Bekir, S.S., Sorger, P.K., Näthke, I.S. Nat. Cell Biol. (2001)
- The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway. Heinen, C.D., Goss, K.H., Cornelius, J.R., Babcock, G.F., Knudsen, E.S., Kowalik, T., Groden, J. Gastroenterology (2002)
- Deletion of an amino-terminal sequence beta-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor protein. Munemitsu, S., Albert, I., Rubinfeld, B., Polakis, P. Mol. Cell. Biol. (1996)
- Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Sparks, A.B., Morin, P.J., Vogelstein, B., Kinzler, K.W. Cancer Res. (1998)
- Adenomatous polyposis coli determines sensitivity to histone deacetylase inhibitor-induced apoptosis in colon cancer cells. Huang, X., Guo, B. Cancer Res. (2006)
- Analysis of the signaling activities of localization mutants of beta-catenin during axis specification in Xenopus. Miller, J.R., Moon, R.T. J. Cell Biol. (1997)
- Characterization of the E-cadherin/catenin complex in colorectal carcinoma cell lines. El-Bahrawy, M., Poulsom, R., Rowan, A.J., Tomlinson, I.T., Alison, M.R., Poulsom, S.R., Tomlinson, I.T. International journal of experimental pathology. (2004)
- Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin. Kishida, S., Yamamoto, H., Ikeda, S., Kishida, M., Sakamoto, I., Koyama, S., Kikuchi, A. J. Biol. Chem. (1998)
- IKKalpha stabilizes cytosolic beta-catenin by inhibiting both canonical and non-canonical degradation pathways. Carayol, N., Wang, C.Y. Cell. Signal. (2006)
- RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells. Renner, C., Pfitzenmeier, J.P., Gerlach, K., Held, G., Ohnesorge, S., Sahin, U., Bauer, S., Pfreundschuh, M. J. Immunol. (1997)
- Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival. Brocardo, M., Lei, Y., Tighe, A., Taylor, S.S., Mok, M.T., Henderson, B.R. J. Biol. Chem. (2008)
- Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acid residue repeats of the APC protein. Tickenbrock, L., Kössmeier, K., Rehmann, H., Herrmann, C., Müller, O. J. Mol. Biol. (2003)
- Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exit. Stewart, S., Fang, G. Mol. Cell. Biol. (2005)
- KEN-Box-dependent Degradation of the Bub1 Spindle Checkpoint Kinase by the Anaphase-promoting Complex/Cyclosome. Qi, W., Yu, H. J. Biol. Chem. (2007)
- Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1. Stewart, S., Fang, G. Cancer Res. (2005)
- Comparison of activated protein C/protein S-mediated inactivation of human factor VIII and factor V. Lu, D., Kalafatis, M., Mann, K.G., Long, G.L. Blood (1996)
- Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation. Fagman, H., Larsson, F., Arvidsson, Y., Meuller, J., Nordling, M., Martinsson, T., Helmbrecht, K., Brabant, G., Nilsson, M. Oncogene (2003)
- The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules. Mimori-Kiyosue, Y., Shiina, N., Tsukita, S. Curr. Biol. (2000)
- NKG2D-mediated cytotoxicity toward oligodendrocytes suggests a mechanism for tissue injury in multiple sclerosis. Saikali, P., Antel, J.P., Newcombe, J., Chen, Z., Freedman, M., Blain, M., Cayrol, R., Prat, A., Hall, J.A., Arbour, N. J. Neurosci. (2007)
- Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin. Choi, J., Park, S.Y., Costantini, F., Jho, E.H., Joo, C.K. J. Biol. Chem. (2004)
- The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid. Eisinger, A.L., Nadauld, L.D., Shelton, D.N., Peterson, P.W., Phelps, R.A., Chidester, S., Stafforini, D.M., Prescott, S.M., Jones, D.A. J. Biol. Chem. (2006)
- Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study. Lüchtenborg, M., Weijenberg, M.P., Wark, P.A., Saritas, A.M., Roemen, G.M., van Muijen, G.N., de Bruïne, A.P., van den Brandt, P.A., de Goeij, A.F. BMC Cancer (2005)
- Gut-enriched Krüppel-like factor regulates colonic cell growth through APC/beta-catenin pathway. Stone, C.D., Chen, Z.Y., Tseng, C.C. FEBS Lett. (2002)
- APC 3 x 15 beta-catenin-binding domain potentiates beta-catenin association to TBP and upregulates TCF-4 transcriptional activity. Roura, S., Martínez, D., Piedra, J., Miravet, S., García de Herreros, A., Duñach, M. Biochem. Biophys. Res. Commun. (2003)
- Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. Amit, S., Hatzubai, A., Birman, Y., Andersen, J.S., Ben-Shushan, E., Mann, M., Ben-Neriah, Y., Alkalay, I. Genes Dev. (2002)
- Immunohistochemical expression of MYH protein can be used to identify patients with MYH-associated polyposis. Di Gregorio, C., Frattini, M., Maffei, S., Ponti, G., Losi, L., Pedroni, M., Venesio, T., Bertario, L., Varesco, L., Risio, M., Ponz de Leon, M. Gastroenterology (2006)
- Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis. Su, L.K., Barnes, C.J., Yao, W., Qi, Y., Lynch, P.M., Steinbach, G. Am. J. Hum. Genet. (2000)
- A functional assay for mutations in tumor suppressor genes caused by mismatch repair deficiency. Ji, H.P., King, M.C. Hum. Mol. Genet. (2001)
- Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma. Suehiro, Y., Wong, C.W., Chirieac, L.R., Kondo, Y., Shen, L., Webb, C.R., Chan, Y.W., Chan, A.S., Chan, T.L., Wu, T.T., Rashid, A., Hamanaka, Y., Hinoda, Y., Shannon, R.L., Wang, X., Morris, J., Issa, J.P., Yuen, S.T., Leung, S.Y., Hamilton, S.R. Clin. Cancer Res. (2008)
- Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells. Reinacher-Schick, A., Gumbiner, B.M. J. Cell Biol. (2001)
- Role of the adenomatous polyposis coli gene product in human cardiac development and disease. Rezvani, M., Liew, C.C. J. Biol. Chem. (2000)
- Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors). Alman, B.A., Li, C., Pajerski, M.E., Diaz-Cano, S., Wolfe, H.J. Am. J. Pathol. (1997)
- Adenomatous polyposis coli gene mutation alters proliferation through its beta-catenin-regulatory function in aggressive fibromatosis (desmoid tumor). Li, C., Bapat, B., Alman, B.A. Am. J. Pathol. (1998)
- Optimal use of a panel of methylation markers with GSTP1 hypermethylation in the diagnosis of prostate adenocarcinoma. Tokumaru, Y., Harden, S.V., Sun, D.I., Yamashita, K., Epstein, J.I., Sidransky, D. Clin. Cancer Res. (2004)