Disease relevance of PBPP1

• Perinatal brachial plexus palsy (PBPP) has been traditionally classified into three types: upper plexus palsy (Erb's) affecting the C5, C6, and +/- C7 nerve roots, lower plexus palsy (Klumpke's) affecting the C8 and T1 nerve roots, and total plexus palsy [1].

High impact information on PBPP1

• Circulating concentrations of progesterone, progesterone-binding plasma proteins (PBPP) and oestradiol-17 beta in pregnant porcupines remained relatively low until Days 25-30 post coitum [2].
• We found that D-threo-1-phenyl-2-benzyloxycarbonylamino-3-pyrrolidino-1-pr opanol (PBPP) was a most potent inhibitor, showing an IC50 of 0.3 microM [3].
• In cultured cells, PBPP was able to deplete glycosphingolipids without affecting cell growth or the ceramide level [3].
• The aim of this study was to test the hypothesis of genetic predisposition for PBPP [4].
• Perinatal brachial plexus palsy (PBPP) is a handicap quite commonly encountered in daily routine [4].

Associations of PBPP1 with chemical compounds

• The pattern of PBPP synthesis, as suggested by circulating concentrations, was closely related to that of plasma progesterone, with values remaining low (less than 20 pmol/ml) until Day 31 post coitum, reaching peak levels at Days 50-56 and Days 73-77 post coitum [2].

References