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HRH1  -  histamine receptor H1

Homo sapiens

Synonyms: H1-R, H1R, HH1R, Histamine H1 receptor, hisH1
 
 
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Disease relevance of HRH1

 

Psychiatry related information on HRH1

 

High impact information on HRH1

 

Chemical compound and disease context of HRH1

 

Biological context of HRH1

 

Anatomical context of HRH1

 

Associations of HRH1 with chemical compounds

 

Physical interactions of HRH1

  • Small H1R agonists and 2-phenylhistamines interacted differentially with human and guinea pig H2R in terms of potency and efficacy, respectively [25].
 

Regulatory relationships of HRH1

 

Other interactions of HRH1

 

Analytical, diagnostic and therapeutic context of HRH1

References

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  2. Characteristics of the binding of [3H]-mepyramine to intact human U373 MG astrocytoma cells: evidence for histamine-induced H1-receptor internalisation. Hishinuma, S., Young, J.M. Br. J. Pharmacol. (1995) [Pubmed]
  3. Structural basis for inhibition of histamine N-methyltransferase by diverse drugs. Horton, J.R., Sawada, K., Nishibori, M., Cheng, X. J. Mol. Biol. (2005) [Pubmed]
  4. Pharmacology of antihistamines. Woodward, J.K. J. Allergy Clin. Immunol. (1990) [Pubmed]
  5. The effect of histamine-H1 receptor antagonism with terfenadine on concentration-related AMP-induced bronchoconstriction in asthma. Phillips, G.D., Polosa, R., Holgate, S.T. Clin. Exp. Allergy (1989) [Pubmed]
  6. Individual differences in central nervous system response to antihistamines (H1-receptor antagonists). Simons, F.E., Fraser, T.G., Reggin, J.D., Simons, K.J. Ann. Allergy Asthma Immunol. (1995) [Pubmed]
  7. Molecular pharmacology of second-generation antihistamines. Grant, J.A. Allergy and asthma proceedings : the official journal of regional and state allergy societies. (2000) [Pubmed]
  8. Histamine selectively enhances human immunoglobulin E (IgE) and IgG4 production induced by anti-CD58 monoclonal antibody. Kimata, H., Fujimoto, M., Ishioka, C., Yoshida, A. J. Exp. Med. (1996) [Pubmed]
  9. Histamine suppresses gene expression and synthesis of tumor necrosis factor alpha via histamine H2 receptors. Vannier, E., Miller, L.C., Dinarello, C.A. J. Exp. Med. (1991) [Pubmed]
  10. Phospholipase cbeta 3 mediates the scratching response activated by the histamine h1 receptor on C-fiber nociceptive neurons. Han, S.K., Mancino, V., Simon, M.I. Neuron (2006) [Pubmed]
  11. Histamine enhances interleukin (IL)-1-induced IL-1 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. Comparison with IL-1 receptor antagonist. Vannier, E., Dinarello, C.A. J. Clin. Invest. (1993) [Pubmed]
  12. Analysis of histamine receptors in the central thermoregulatory mechanism of Mastomys natalensis. Dhawan, B.N., Shukla, R., Srimal, R.C. Br. J. Pharmacol. (1982) [Pubmed]
  13. Cimetidine treatment of recalcitrant acute allergic urticaria. Rusli, M. Annals of emergency medicine. (1986) [Pubmed]
  14. Histamine provocation of clinical coronary artery spasm: implications concerning pathogenesis of variant angina pectoris. Ginsburg, R., Bristow, M.R., Kantrowitz, N., Baim, D.S., Harrison, D.C. Am. Heart J. (1981) [Pubmed]
  15. A double blind trial of H1 and H2 receptor antagonists in the treatment of atopic dermatitis. Frosch, P.J., Schwanitz, H.J., Macher, E. Arch. Dermatol. Res. (1984) [Pubmed]
  16. Structure of the human histamine H1 receptor gene. De Backer, M.D., Loonen, I., Verhasselt, P., Neefs, J.M., Luyten, W.H. Biochem. J. (1998) [Pubmed]
  17. Two threonine residues and two serine residues in the second and third intracellular loops are both involved in histamine H1 receptor downregulation. Horio, S., Kato, T., Ogawa, M., Fujimoto, K., Fukui, H. FEBS Lett. (2004) [Pubmed]
  18. Stable expression of human H1-histamine-receptor cDNA in Chinese hamster ovary cells. Pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene. Moguilevsky, N., Varsalona, F., Noyer, M., Gillard, M., Guillaume, J.P., Garcia, L., Szpirer, C., Szpirer, J., Bollen, A. Eur. J. Biochem. (1994) [Pubmed]
  19. Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells. Gutzmer, R., Diestel, C., Mommert, S., Köther, B., Stark, H., Wittmann, M., Werfel, T. J. Immunol. (2005) [Pubmed]
  20. Chromosomal localization of the human histamine H1-receptor gene. Le Coniat, M., Traiffort, E., Ruat, M., Arrang, J.M., Berger, R. Hum. Genet. (1994) [Pubmed]
  21. Molecular and cellular analysis of histamine H1 receptors on cultured smooth muscle cells. Mitsuchashi, M., Payan, D.G. J. Cell. Biochem. (1989) [Pubmed]
  22. Molecular cloning of the human histamine H1 receptor gene. Fukui, H., Fujimoto, K., Mizuguchi, H., Sakamoto, K., Horio, Y., Takai, S., Yamada, K., Ito, S. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  23. Reactivity of heparin with the human plasma heparin-binding proteins thrombin, antithrombin III, and apolipoproteins E and B-100. Cardin, A.D., Barnhart, R.L., Witt, K.R., Jackson, R.L. Thromb. Res. (1984) [Pubmed]
  24. Expression and function of histamine receptors 1 and 2 on human monocyte-derived dendritic cells. Gutzmer, R., Langer, K., Lisewski, M., Mommert, S., Rieckborn, D., Kapp, A., Werfel, T. J. Allergy Clin. Immunol. (2002) [Pubmed]
  25. Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. Seifert, R., Wenzel-Seifert, K., Burckstummer, T., Pertz, H.H., Schunack, W., Dove, S., Buschauer, A., Elz, S. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  26. Histamine receptors on lymphocytes: distribution and functional significance. Sachs, B., Hertl, M., Merk, H.F. Skin Pharmacol. Appl. Skin Physiol. (2000) [Pubmed]
  27. The human histamine H2-receptor couples more efficiently to Sf9 insect cell Gs-proteins than to insect cell Gq-proteins: limitations of Sf9 cells for the analysis of receptor/Gq-protein coupling. Houston, C., Wenzel-Seifert, K., Bürckstümmer, T., Seifert, R. J. Neurochem. (2002) [Pubmed]
  28. Histaminergic regulation of prolactin secretion: dose-response relationship and possible involvement of the dopaminergic system. Knigge, U., Thuesen, B., Christiansen, P.M. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  29. Histamine enhanced the TNF-alpha-induced expression of E-selectin and ICAM-1 on vascular endothelial cells. Miki, I., Kusano, A., Ohta, S., Hanai, N., Otoshi, M., Masaki, S., Sato, S., Ohmori, K. Cell. Immunol. (1996) [Pubmed]
  30. Pathophysiology of the fundic enterochromaffin-like (ECL) cell and gastric carcinoid tumours. Modlin, I.M., Lawton, G.P., Miu, K., Kidd, M., Luque, E.A., Sandor, A., Tang, L.H. Annals of the Royal College of Surgeons of England. (1996) [Pubmed]
  31. Histamine receptors in human detrusor smooth muscle cells: physiological properties and immunohistochemical representation of subtypes. Neuhaus, J., Weimann, A., Stolzenburg, J.U., Dawood, W., Schwalenberg, T., Dorschner, W. World journal of urology. (2006) [Pubmed]
  32. Recent advances in molecular pharmacology of the histamine systems: immune regulatory roles of histamine produced by leukocytes. Tanaka, S., Ichikawa, A. J. Pharmacol. Sci. (2006) [Pubmed]
  33. Mechanisms of vasoactive intestinal peptide-mediated vasodilation in human skin. Wilkins, B.W., Chung, L.H., Tublitz, N.J., Wong, B.J., Minson, C.T. J. Appl. Physiol. (2004) [Pubmed]
  34. Histamine influences the expression of the interleukin-6 receptor on human lymphoid, monocytoid and hepatoma cell lines. Merétey, K., Falus, A., Taga, T., Kishimoto, T. Agents Actions (1991) [Pubmed]
 
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